Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$130K - $160K *

Empower AI innovation by designing and building robust tooling for deploying AI agents in production. Collaborate with cross-functional teams to enhance infrastructure reliability and developer experi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K *

Champion marketing analytics to drive insights and improve enrollment performance. Collaborate with teams to evaluate marketing effectiveness, optimize strategies, and enhance decision-making through...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Elevate automation reliability by optimizing robotic systems in logistics. Drive performance, minimize downtime, and enhance operational efficiency through proactive maintenance and continuous improve...

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $110K *

Lead the charge in building innovative agents that enhance user experiences. Collaborate across teams to develop, deploy, and refine AI-driven solutions, ensuring quality and efficiency while addressi...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Media

$112K - $179K *

Shape the future of data-driven insights by leveraging advanced machine learning techniques, collaborating with cross-functional teams, and communicating complex analyses to drive impactful business d...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$69K - $95K *

Join a team that's dedicated to leveraging data analytics to drive sales success. As a key partner, you'll provide insights and innovative solutions that enhance decision-making and support strategic...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Food & Beverages

$110K - $130K *

Elevate your career by developing and optimizing machine learning models, collaborating with cross-functional teams to drive data-driven solutions and enhance predictive analytics in a dynamic, Agile...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Drive excellence by leading model audits and mentoring a dynamic team. Collaborate on complex financial models, ensuring accuracy and strategic growth, while enhancing methodologies to deliver top-not...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $160K *

Join a team that's transforming healthcare with AI solutions. As an AI Solutions Engineer, you'll develop integrations and tools that enhance customer workflows, bridging the gap between clients and o...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$137K - $188K *

Drive innovation in data engineering by leading a dedicated team to develop robust data pipelines, ensuring high-quality data products that empower business decisions and enhance our digital capabilit...

3 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$100K - $120K *

Unlock potential by designing and building robust data pipelines for healthcare transactions. Collaborate with partners to ensure seamless integration and reliability of data systems, enhancing operat...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Transform data into actionable insights by mastering analytics across diverse domains. Collaborate with cross-functional teams to optimize reporting workflows and drive impactful solutions in a fast-p...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Legal & Accounting

$175K - $185K *

Join a team that's redefining finance analytics by leading strategic forecasting and performance management. Drive impactful financial insights and methodologies while collaborating with leadership to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$88K - $125K *

Unlock potential by leveraging advanced analytics and consultative skills to drive client success in the Consumer Healthcare vitamins sector. Collaborate cross-functionally to deliver insights and fos...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Inspire data-driven decision-making as you lead analytics and predictive modeling efforts. Collaborate across teams to enhance patient engagement, forecast demand, and measure impact, driving strategi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Lead the charge in transforming complex revenue-cycle challenges into robust, production-ready AI models, ensuring statistical integrity and operational reliability while managing end-to-end data pipe...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Innovate data solutions by developing complex reports and analyses to support senior management and client needs. Collaborate with teams to enhance data literacy and provide technical guidance across...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$89K - $125K *

Partner with us to integrate new firms into our IT environment, managing Microsoft 365 migrations and Active Directory consolidations while collaborating with cross-functional teams to ensure seamless...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$107K - $152K *

Transform the future of AI at scale by designing and deploying LLM-powered systems to enhance content quality and safety. Collaborate with a dynamic ML team to tackle complex challenges and make a mea...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$154K - $185K *

Lead the charge in developing advanced AI systems and automation platforms. Own multi-agent architectures and backend services that optimize workflows across teams, driving operational efficiency and...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$230K - $322K *

Accelerate progress at shaping foundational models and user understanding while collaborating with cross-functional teams to drive impactful machine learning initiatives and mentor top talent in a dyn...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$146K - $229K *

Lead a dynamic analytics team to create trusted measures, ensure actionable insights, and foster partnerships for data integrity and impact measurement across business functions...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$145K - $170K *

Join a team that's redefining product strategy through advanced analytics. Leverage your expertise to drive insights, enhance product performance, and collaborate with stakeholders to make impactful b...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$120K - $145K *

Unlock the potential of data as a senior data scientist, transforming U.S. Army enterprise data into impactful analytical products and workflows, while collaborating with cross-functional teams to dri...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$320K - $405K *

Transform the future of data center engineering by resolving on-site technical issues, collaborating with contractors, and ensuring project success through effective problem-solving and communication...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.