Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$130K - $155K *
Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...
5 days ago
$120K - $190K *
Empower project success by managing sales opportunities, creating piping layouts, and fostering strong customer relationships. Utilize your engineering expertise to navigate complex situations and del...
3 weeks ago
$95K - $115K *
Champion healthcare solutions by managing integrations and providing expert support. Drive projects and improve processes as a Senior Interface Analyst in a dynamic and innovative environment, ensurin...
Reposted 1 week ago
Security Operations Engineer II
$84K - $124K *
Drive the evolution of Cyber Defense by engineering and automating security operations, enhancing incident response, and maintaining enterprise security platforms to ensure robust protection and swift...
2 weeks ago
$110K - $130K *
Lead the charge in transforming client operations by identifying and accelerating AI-driven opportunities. Collaborate with stakeholders to frame business challenges, prototype solutions, and drive me...
Reposted 1 week ago
$94K - $107K *
Support and enhance data governance operations by collaborating with teams to implement standards, manage data cataloging, and drive tool adoption, ensuring compliance and effective governance workflo...
3 weeks ago
Senior Backend Engineer, Onboarding and Provisioning
$199K - $235K *
Lead the charge in building robust backend services that streamline customer onboarding and provisioning workflows, ensuring seamless activation and reliable integrations across teams for optimal user...
4 days ago
Associate Director, Real-World Analytics Programming
$186K - $233K *
Empower the future of real-world analytics by leading programming activities for observational studies, ensuring high-quality deliverables through collaboration with cross-functional teams and innovat...
3 weeks ago
Staff Data Engineer - GRC Enablement (OLTP)
$149K - $240K *
Help us build robust data foundations by designing Postgres schemas and optimizing transactional models. Collaborate with teams to ensure reliable data systems and mentor engineers in data fluency, en...
3 weeks ago
Senior Security Engineer - Threat Detection
$157K - $238K *
Pioneer innovative threat detection engineering solutions that protect our infrastructure. Collaborate across teams to enhance our detection platform through advanced telemetry, improve pipeline relia...
Reposted 2 days ago
Facility Coding Quality Integrity Analyst - Inpatient
$73K - $110K *
Analyze coding quality data and support compliance initiatives to enhance hospital coding accuracy. Collaborate with teams to develop guidance and conduct audits, ensuring adherence to regulatory stan...
Yesterday
$105K - $126K *
Lead and optimize subcontract management by negotiating agreements, ensuring compliance, and collaborating with stakeholders to drive successful federal contracting outcomes while mentoring junior sta...
3 weeks ago
Technical Product Manager, Data Platform
$120K - $145K *
Transform the data platform by owning product direction and delivery. Collaborate across teams to prioritize needs, streamline processes, and ensure engineering focuses on impactful projects while enh...
2 weeks ago
$75K - $158K *
Transform data engineering processes by building and optimizing scalable ETL pipelines in a dynamic environment, contributing to critical Oracle ERP projects ensuring compliance and data integrity for...
Reposted today
Senior Software Engineer (Python / AI Insurance SaaS)
$200K - $225K *
Drive the design and delivery of innovative AI-driven applications. Oversee the full development lifecycle, ensuring scalability and reliability in multi-tenant enterprise solutions while collaboratin...
Reposted 2 days ago
$80K - $95K *
Lead the end-to-end recruiting process, enhancing strategies and partnerships across departments. Drive high-volume hiring with autonomy, ensuring a seamless candidate experience while collaborating c...
1 week ago
Google (AGBG) Mid Market Sales Account Executive
$122K - $187K *
Lead the charge in driving transformative sales for Google Cloud solutions, guiding clients through technology transformations while managing a robust pipeline and collaborating with cross-functional...
2 weeks ago
$75K - $158K *
Transform business objectives into actionable insights by leveraging Agile methodologies. Collaborate with cross-functional teams to refine backlogs, create user stories, and ensure alignment between...
2 days ago
$75K - $158K *
Empower cross-functional teams by analyzing requirements, facilitating Agile processes, and ensuring alignment between business goals and technical execution. Drive effective backlog management and su...
2 days ago
$75K - $158K *
Empower cross-functional teams as a Business Analyst, driving Agile practices, refining backlogs, and aligning business objectives with technical execution to enhance project outcomes and stakeholder...
Reposted 2 weeks ago
Senior Manager, Engineering - Onboarding
$217K - $264K *
Lead and optimize the engineering team to enhance customer onboarding and lifecycle management, ensuring robust risk management and compliance across products while fostering a high-performing, inclus...
5 days ago
Business and Data Analyst [U.S. Citizenship Required, Public Trust Suitability]
$90K *
Shape the future of business analysis by connecting program needs with technical solutions. Leverage your Salesforce expertise to enhance workflows, gather requirements, and collaborate with stakehold...
Reposted 2 days ago
Oracle Fusion Data Conversion Consultant (Functional and Technical)
$110K - $130K *
Engineer your career by leading Oracle Fusion data conversions from legacy systems. Collaborate with finance SMEs and AI agents to ensure accurate data mapping, error resolution, and reconciliation fo...
Yesterday
Senior Account Executive II, Federal DOW/Army/Navy/Air Force/Pentagon
$140K - $175K *
Transform your career by engaging with federal clients, driving enterprise solutions, and building lasting relationships in a dynamic SaaS environment. Leverage your technical expertise to exceed sale...
Reposted 2 days ago
Principal Enterprise Architect
$150K - $180K *
Unlock potential by shaping enterprise AI strategy and architecture, driving scalable solutions across applications and data platforms. Collaborate with leaders to ensure responsible AI adoption and g...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.