Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Enterprise Account Executive, Healthcare
$272K - $374K *
Develop strategic relationships with key healthcare accounts, driving innovation and sales growth. Leverage your expertise in big data and cloud technologies to exceed targets and deliver exceptional...
3 weeks ago
Clinical Applications Specialist, Contrast Media Delivery Solutions
$100K - $150K *
Join a team that's dedicated to enhancing clinical support through technical expertise and customer training. Drive product demonstrations and ensure customer satisfaction while collaborating with sal...
2 weeks ago
$120K - $145K *
Elevate security standards by leading bug bounty programs, conducting audits, and enhancing software supply chain security. Collaborate across teams to build innovative tools that protect users and en...
2 weeks ago
$95K - $115K *
Drive impactful marketing strategies by transforming complex data into actionable insights, collaborating with senior stakeholders, and leading analytical projects from start to finish, all while fost...
Reposted 3 weeks ago
$80K - $95K *
Join a team that's dedicated to enhancing business systems integration. Collaborate closely with Accounting to develop and support JD Edwards Orchestrations, leveraging modern technologies and AI tool...
2 weeks ago
AI Training Partnerships Manager
$110K - $130K *
Elevate your career by building strategic partnerships in the AI ecosystem. Collaborate with customers to tackle complex AI training challenges and shape innovative solutions, driving growth for a pio...
1 week ago
$80K - $95K *
Drive analytical excellence by auditing freight contracts and invoices, ensuring compliance and accuracy. Collaborate with teams to enhance audit processes and mentor junior analysts, contributing to...
1 week ago
$80K - $95K *
Innovate with us as a Process Engineer, optimizing workflows and enhancing operational efficiency for new data center projects. Collaborate across teams to implement solutions that drive productivity...
2 weeks ago
Staff Product Manager, Growth & E-commerce Experimentation
$161K - $190K *
Transform the digital commerce experience by owning a high-velocity experimentation roadmap. Collaborate across teams to enhance customer journeys, improve conversion rates, and establish a robust exp...
3 weeks ago
$130K - $160K *
Advance AI engineering by designing LLM-powered systems and optimizing data retrieval architectures. Collaborate with cross-functional teams to enhance CoreStory's narrative intelligence platform with...
Reposted 2 weeks ago
Supply Chain Optimization Data Scientist Senior Consultant
$116K - $229K *
Elevate your career by driving supply chain optimization through data science. Collaborate with clients to design analytical solutions, enhance decision-making, and transform value chains into competi...
3 weeks ago
Principal Software Engineer Search Platform
$150K - $180K *
Elevate our search capabilities by architecting high-scale solutions, leading multi-quarter transformations, and ensuring operational excellence across a global cloud infrastructure while mentoring em...
3 weeks ago
Senior Marketing Operations Manager
$145K - $185K *
Join a team that's driving marketing excellence by owning and scaling our marketing operations. You'll lead cross-functional projects, optimize tech stacks, and ensure data integrity to enhance pipeli...
3 weeks ago
Senior Business Intelligence Analyst - Enterprise Analytics
$90K - $115K *
Lead the charge in transforming complex business needs into impactful analytic products. Collaborate with stakeholders to design, develop, and maintain reusable semantic models that enhance decision-m...
1 week ago
Lead AI and Data Solution Engineer
$200K - $215K *
Drive the design and deployment of innovative data and AI solutions, leveraging expertise in LLMs, agentic AI, and cloud technologies to enhance business value and ensure compliance with industry stan...
3 weeks ago
$80K - $95K *
Champion exceptional research outcomes by guiding clients through complex projects. Leverage your expertise in methodology and analysis to deliver actionable insights, while collaborating with cross-f...
2 weeks ago
Project Engineer - Solar and Storage
$95K - $115K *
Lead solar resource assessments and performance analytics for utility-scale projects. Engage with clients, optimize energy yield, and enhance methodologies while ensuring operational excellence in sol...
Yesterday
Clinical Operations and Analytics Consultant
$82K - $128K *
Shape data-driven strategies by developing and automating analytics solutions. Collaborate with cross-functional teams to enhance reporting capabilities and optimize operational performance in a dynam...
2 weeks ago
$75K - $105K *
Champion project success by collaborating with teams to develop technical strategies, manage client communications, and ensure profitable project execution across diverse industrial applications...
5 days ago
Director, AI Platforms, Global
$200K - $210K *
Join a dynamic team to lead AI platform strategy and operations, ensuring seamless access and governance while driving enterprise-wide adoption and continuous improvement of innovative AI solutions...
2 weeks ago
Director, Marketing Operations
$150K - $180K *
Lead the charge in optimizing marketing operations to drive developer adoption, pipeline growth, and revenue. Oversee systems, processes, and insights while collaborating with cross-functional teams t...
2 weeks ago
$95K - $115K *
Transform healthcare delivery by leveraging your Epic Cadence expertise to design, build, and optimize scheduling workflows. Collaborate with teams to ensure successful project outcomes and enhance pa...
6 days ago
$110K - $130K *
Join a team that's shaping federal policy and advocacy. As a Government Affairs Manager, you'll engage with Congress and the Executive Branch, driving strategic initiatives across key domestic issues...
2 weeks ago
$160K - $187K *
Grow your career with a hands-on Engineering Manager role leading a dynamic team to enhance an AI-powered healthcare hiring platform, ensuring quality, reliability, and innovation across multiple tech...
6 days ago
Senior Analyst Treasury Cash Forecasting & Analysis
$79K - $112K *
Transform cash forecasting processes by leveraging technology and analytics. Collaborate with Treasury leadership to enhance cash flow insights and automate reporting, ensuring accuracy and efficiency...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.