Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$165K - $215K *
Engage with innovative AI/ML teams to drive customer success in leveraging AI. You'll cultivate client relationships, manage adoption, and ensure measurable impacts through tailored solutions and stra...
Reposted 4 days ago
Account Executive - Business Development Sales, Healthcare SaaS
$150K - $180K *
Advance healthcare solutions by building executive relationships and driving enterprise sales. Lead the sales lifecycle, develop strategic accounts, and leverage modern tools to optimize revenue growt...
5 days ago
$110K - $130K *
Advance data solutions by building and maintaining pipelines, optimizing performance, and ensuring data integrity. Collaborate with cross-functional teams to deliver analytics and reporting data that...
Yesterday
$80K - $95K *
Join a team that's driving renewable energy solutions by cultivating client relationships and generating new business through a consultative sales approach. Collaborate with operations to deliver tail...
1 week ago
$90K - $110K *
Grow your career with a dynamic team focused on generating new business in the public sector. Utilize a consultative sales approach to build relationships and deliver tailored solutions, driving reven...
1 week ago
Senior Customer Success Engineer, Audit
$110K - $130K *
Empower audit teams to excel with a hands-on role that drives software adoption, enhances workflow efficiency, and delivers measurable outcomes. Collaborate across functions to modernize audit practic...
Reposted 1 week ago
$150K - $160K *
Champion cloud and application security by enhancing AWS practices, collaborating with cross-functional teams, and driving continuous improvement to ensure secure and compliant environments...
Reposted 4 days ago
$80K - $95K *
Partner with us to enhance clinical IT solutions as an Epic Analyst II, providing critical support, training, and implementation for Epic EHR systems. Collaborate with teams to optimize workflows and...
2 weeks ago
$192K - $240K *
Empower innovation as you lead complex AI system design and delivery, influencing architecture and engineering practices. Collaborate across teams to ensure scalable, high-quality solutions with signi...
Reposted 2 weeks ago
Machine Learning Operations (MLOps) Engineer
$127K - $155K *
Join us to build and operate robust MLOps platforms, ensuring seamless deployment and management of machine learning models. Collaborate with cross-functional teams to enhance model performance and de...
3 weeks ago
Machine Learning Operations (MLOps) Engineer
$127K - $155K *
Drive the future of machine learning operations by building and managing robust pipelines, ensuring model performance, and collaborating with cross-functional teams to deliver impactful business solut...
3 weeks ago
$105K - $140K *
Contribute to the evolution of cloud platform capabilities by designing and building backend services for orchestration and job execution, ensuring reliable service coordination and operational visibi...
4 weeks ago
$125K - $150K *
Drive strategic tracking engagements by providing expert guidance and oversight. Collaborate with clients and teams to ensure high-quality outcomes, effective communication, and successful project exe...
3 weeks ago
Information Security Architect - AI
$170K - $212K *
Elevate AI security by designing robust frameworks to protect systems from threats. Collaborate with cross-functional teams to ensure compliance and ethical use, while implementing strategies that saf...
3 weeks ago
Contact Center Data Analyst III
$70K - $126K *
Contribute to impactful data analytics projects, leading efforts in Power BI and SQL to enhance business operations. Collaborate with teams to extract insights from healthcare data, ensuring complianc...
Today
$80K - $95K *
Elevate your career by managing and optimizing multi-platform paid social campaigns. Leverage data-driven insights to enhance client ROI while collaborating with creative teams and leading strategic i...
Yesterday
$86K - $137K *
Optimize project outcomes as you manage small to medium-sized initiatives. Collaborate across teams, navigate risks, and ensure timely delivery of quality solutions while enhancing communication and s...
Reposted 1 week ago
Avionics/ Staff Command and Data Handling Engineer
$117K - $195K *
Join a team that's developing cutting-edge avionics architectures for diverse missions. Leverage your expertise in command and data handling to optimize system performance and ensure seamless integrat...
4 weeks ago
Automation Test Engineer - 6568322
$128K - $149K *
Unlock potential by leading test automation initiatives, developing scalable frameworks, and implementing CI/CD processes. Collaborate in Agile environments to enhance quality across web, API, and mai...
Yesterday
Data Mining Specialist (Payment Integrity)
$93K - $134K *
Drive impactful data mining initiatives by analyzing complex claims across Medicare, Medicaid, and Commercial sectors. Leverage your expertise to identify anomalies and enhance recovery opportunities...
5 days ago
Transformation Consultant, Professional Services
$74K - $137K *
Lead the charge in transforming workflows with AI, driving adoption and measurable impact in legal, tax, and trade sectors. Collaborate with clients and teams to design, implement, and evaluate innova...
3 weeks ago
Senior Software Engineer - Data Infrastructure
$175K - $200K *
Optimize our data infrastructure platform by enhancing automation, observability, and stability. Drive architectural changes to support long-term service requirements while ensuring high throughput an...
2 weeks ago
$110K - $130K *
Transform search visibility and traffic by leading SEO initiatives across diverse domains. Collaborate cross-functionally to optimize content, diagnose technical issues, and leverage data for impactfu...
3 weeks ago
$88K - $154K *
Optimize and integrate the manufacturing process for hazardous materials, taking ownership from design through commissioning. Collaborate with multidisciplinary teams to ensure safety and efficiency i...
Reposted 1 week ago
Software Engineer, Infrastructure Engineering
$164K - $229K *
Elevate infrastructure reliability and performance by architecting scalable solutions, collaborating across teams, and driving end-to-end software delivery to enhance user experience and system resili...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.