Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$90K - $110K *
Champion the recruitment process by sourcing top technical talent, collaborating with leadership, and executing full-cycle hiring strategies to meet business objectives in a fast-paced startup environ...
Today
$88K - $105K *
Engage in comprehensive finance integration for acquired companies, ensuring accurate data mapping, system conversion, and post-close stabilization. Collaborate with cross-functional teams to streamli...
1 week ago
Continuous Improvement Analyst III
$80K - $95K *
Advance operational excellence by leading continuous improvement initiatives, optimizing processes, and engaging stakeholders across departments to drive measurable results and enhance efficiency in a...
5 days ago
Senior Backend Engineer, External
$199K - $235K *
Innovate backend solutions by designing, building, and maintaining scalable services for external pentesting. Collaborate across teams to enhance user experience and ensure system performance, reliabi...
2 weeks ago
$104K - $166K *
Unlock your potential as you build and enhance a cutting-edge data platform, driving innovation in federal background investigations. Collaborate in a high-trust, remote environment while ensuring dat...
Yesterday
Senior Site Reliability Engineer - Cloud & AI Platforms
$120K - $145K *
Join a dynamic team to enhance the reliability and performance of enterprise AI and Sitecore platforms on VMware Cloud. Collaborate with cross-functional teams to deliver secure, scalable solutions th...
1 week ago
$110K - $199K *
Develop and maintain scalable data pipelines, leveraging Snowflake and cloud tools to enhance data quality and accessibility. Mentor a growing team while driving best practices in data engineering and...
Reposted 1 week ago
$127K - $171K *
Champion high-impact deployments by leveraging data intelligence and AI to drive governance solutions in regulated industries, serving as a trusted advisor to stakeholders and delivering measurable va...
Reposted 3 weeks ago
Manager of Statistical Programming
$132K - $165K *
Drive innovation in oncology diagnostics by leading statistical programming efforts, ensuring data integrity and compliance for clinical trials, while managing a team and collaborating cross-functiona...
2 weeks ago
$95K - $115K *
Unlock potential by designing and implementing a cloud-native architecture. Assess legacy infrastructure, create detailed design documents, and collaborate with engineering to modernize critical data...
Reposted 2 weeks ago
$108K - $140K *
Transform talent acquisition by leading a dynamic recruiting team, driving data-informed strategies, and enhancing candidate experiences to meet organizational growth and workforce needs...
1 week ago
Renewable Senior Performance Engineer
$118K - $180K *
Join a dynamic team to analyze solar PV energy yield assessments for utility-scale projects. Lead performance modeling and mentor engineers while expanding expertise across various renewable energy te...
4 weeks ago
$100K - $120K *
Accelerate growth by driving AI adoption in legal teams. You'll convert inbound leads and build outbound strategies to tap into a vast market, managing demos, trials, and closing deals while collabora...
2 weeks ago
Senior Software Engineer (CCC Auto / Agentic)
$180K - $225K *
Transform the claims process by building robust event-driven systems. As a key player, you'll design, implement, and maintain backend services, ensuring reliability and efficiency while mentoring fell...
Today
$72K - $115K *
Partner with us to design and validate predictive models that enhance business processes across various domains, leveraging data science techniques to drive insights and improve decision-making within...
1 week ago
Software Engineer – AI Applications & ServiceNow
$100K - $130K *
Drive the design and deployment of secure AI applications in cloud environments, integrating advanced technologies like machine learning and ServiceNow solutions to enhance operational efficiency and...
1 week ago
$150K - $180K *
Elevate data privacy standards by leading a comprehensive privacy program. Collaborate across teams to integrate privacy-by-design principles, enhance data governance, and ensure compliance while enab...
2 weeks ago
$90K - $110K *
Join our new Data Engineering team to lead business intelligence initiatives, build trusted data models in Snowflake, and deliver impactful reports in Power BI. Collaborate with stakeholders to enhanc...
1 week ago
Director - Real World Data Scientist
$171K - $299K *
Transform the landscape of Immunology by leading real-world data strategies, driving evidence generation, and influencing clinical outcomes through innovative research and analytics. Collaborate with...
Today
Solution Consultant, Data Center & Cloud Platform
$110K - $130K *
Unlock potential by joining a dynamic team of Solution Consultants, delivering expert guidance on Atlassian products to help clients maximize their investments and achieve strategic outcomes in the Pu...
3 weeks ago
Senior Principal - AI and Data CRL, Infosys Consulting
$210K - $256K *
Transform industry practices by leading large-scale AI and data initiatives, driving business growth and operational excellence within Consumer Products, Retail, and Logistics sectors...
Reposted 1 week ago
Senior Principal - Business Consulting
$210K - $256K *
Lead the charge in driving strategic growth and transformation initiatives, leveraging AI and data expertise to elevate Consumer Products, Retail, and Logistics clients through tailored, impactful sol...
Reposted 1 week ago
$120K - $145K *
Champion innovative database solutions by proactively optimizing performance and guiding clients on cloud strategies. Collaborate with teams to enhance mission-critical systems and ensure seamless ser...
Reposted yesterday
$225K - $265K *
Elevate your career by transforming business workflows into efficient, automated systems. Collaborate with cross-functional teams to implement AI solutions that enhance productivity and drive measurab...
3 weeks ago
$120K - $145K *
Accelerate your career by designing and optimizing secure, scalable cloud infrastructure. Collaborate with cross-functional teams to enhance operational efficiency and ensure high availability for glo...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.