Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$133K - $197K *

Drive impactful research by leading technical evaluations and benchmarks in AI. Collaborate with diverse stakeholders to ensure principled guidance that integrates social and technical considerations...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$195K - $312K *

Zillow is seeking a Principal Applied Scientist to join the Agentic AI team, focusing on developing advanced multimodal technologies for understanding homes. The role involves designing and prototypin...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $145K *

Shape the future of EHS&S solutions by architecting scalable digital frameworks, collaborating with stakeholders to define requirements, and guiding technology lifecycles from design to deployment, en...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$156K - $262K *

Join a dynamic team to design and optimize scalable data pipelines and infrastructure, enabling analytics and AI-driven capabilities. Collaborate across functions to deliver high-quality data solution...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$80K - $95K *

Unlock potential by leading compliance audits, ensuring accurate coding and documentation in anesthesia. Collaborate with teams to mitigate risks, deliver training, and maintain regulatory standards w...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Accelerate progress at the forefront of digital transformation by leading strategic initiatives, ensuring effective governance, and driving organizational change across global teams to enhance program...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$240K - $330K *

Join a team that’s pioneering growth in revenue intelligence by driving new business opportunities in financial services and healthcare. Leverage your extensive sales expertise to build relationships...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$204K - $254K *

Engage as a key member of a high-growth team, driving technical solutions and customer success through expert presentations, collaboration, and innovative problem-solving in a dynamic startup environm...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $110K *

Drive transformation by collaborating with stakeholders to analyze and enhance business processes, ensuring effective technology adoption and operational improvements within a dynamic environment...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead complex, cross-functional marketing initiatives from planning to execution, driving accountability and collaboration across teams while enhancing project management processes and methodologies fo...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $185K *

Contribute to groundbreaking research in deepfake detection and identity authentication. Drive innovative projects, collaborate with engineers, and translate complex models into scalable solutions, en...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$112K - $126K *

Join a team that's driving impactful healthcare solutions by managing complex projects from initiation to stabilization. Collaborate with cross-functional teams to ensure timely delivery and high-qual...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$80K - $120K *

Join our dynamic team as a Geotechnical Engineer, where you'll drive innovative designs for utility infrastructure projects. Collaborate with multidisciplinary experts to ensure technical excellence a...

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$170K - $200K *

Lead the charge in transforming TV, Audio, and Display innovation by identifying inefficiencies, advocating for change, and prototyping solutions that enhance client outcomes and differentiate our off...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Media

$139K - $235K *

Transform compensation strategies by leading program design and execution. Collaborate with cross-functional teams to ensure compliance, enhance processes, and deliver accurate outcomes that attract a...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Transform your career by leading content strategy and production for dynamic digital channels. Drive audience engagement and performance through compelling storytelling, collaboration, and innovative...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$190K - $214K *

Drive strategic finance initiatives by leading FP&A processes, collaborating with cross-functional teams, and building financial models to evaluate product profitability and investments. Shape the fut...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Media

$158K - $234K *

Develop and enhance infrastructure and tools to empower developers in delivering scalable, secure, and reliable software. Collaborate across teams to improve system reliability, automate processes, an...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Partner with us to drive transformative healthcare solutions by managing key accounts, fostering relationships, and ensuring measurable outcomes. Your expertise will enhance provider partnerships and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Drive impactful solutions by maintaining and developing Finance and Procurement systems. Collaborate with teams to analyze requirements, debug SQL queries, and enhance application performance for a se...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $95K *

Unlock operational excellence by leading maintenance planning for fleet reliability and readiness. Collaborate with cross-functional teams to prioritize repairs, manage recalls, and optimize vehicle l...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$120K - $130K *

Elevate your career by leading the design and implementation of complex software solutions. Collaborate with cross-functional teams to drive technical decisions and mentor engineers, ensuring scalable...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $130K *

Drive the design and implementation of complex software solutions, providing technical leadership and mentorship. Collaborate with cross-functional teams to enhance system architecture and ensure high...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Join a dynamic team to lead the creation of impactful scientific content, enhancing medical education and patient outcomes. Collaborate cross-functionally, mentor writers, and drive excellence in heal...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$77K - $202K *

Optimize operational efficiency by analyzing energy and chemical reliability, guiding teams, and developing strategies to enhance performance and productivity in a dynamic consulting environment...

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.