Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$125K - $150K *

Innovate with us to transform manual workflows into efficient AI-driven solutions. As a Staff Forward Deployed Engineer, you'll collaborate closely with teams to streamline processes, enhancing produc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$185K - $217K *

Unlock potential by leading the architecture and deployment of innovative AI/ML systems. Collaborate with stakeholders, mentor engineers, and drive technical strategies while ensuring operational exce...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Lead the charge in delivering innovative AI and Agentforce solutions, managing implementation projects with a focus on customer success. Collaborate with teams to ensure strategic planning and executi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Transform the ScriptMed Cloud Platform by designing and deploying scalable solutions. Collaborate with teams to automate workflows and enhance customer onboarding while ensuring compliance with data s...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Join a team that's driving innovation in AI integration across diverse products. As a Senior Software Engineer, you'll enhance capabilities, collaborate with cross-functional teams, and ensure secure...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$68K - $117K *

Drive process improvement and automation in supply chain operations by applying industrial engineering principles. Collaborate with leadership to enhance workflows and deliver data-driven solutions fo...

3 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Elevate your career by architecting a cutting-edge digital growth engine. Drive enterprise lead generation through innovative strategies, leveraging AI and data analytics to optimize performance and m...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Accelerate progress at customer deployments and adoption, driving value realization across a portfolio of accounts. Leverage technical fluency and business acumen to ensure successful outcomes and dee...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$110K - $120K *

Optimize clinical trial operations by managing study components, ensuring compliance, and collaborating with cross-functional teams to deliver high-quality results on time and within budget...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Champion the development of policy strategies that guide product decisions, ensuring compliance and safety while navigating complex regulatory landscapes. Collaborate with cross-functional teams to tr...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$89K - $107K *

Join a team that's transforming healthcare through data-driven insights. As a Senior Medical Economics Analyst, you'll lead analytics initiatives, mentor a team, and collaborate with leaders to enhanc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$121K - $191K *

Join the team to design and develop scalable software solutions for healthcare supply chain transactions. Collaborate with cross-functional partners to enhance the rules engine and deliver high-qualit...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$106K - $195K *

Empower product and engineering teams by delivering actionable insights that shape strategic decisions. As a Senior Decision Scientist, you'll leverage data to influence roadmaps and resource allocati...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$201K - $239K *

Grow strategic relationships with global enterprise clients, driving EHS and ESG success. Leverage consultative selling to expand accounts, collaborate cross-functionally, and ensure exceptional custo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $208K *

Transform our technology infrastructure by enhancing automation, troubleshooting issues, and fostering collaboration. Bring your expertise to support a scalable infrastructure platform that manages di...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$94K - $266K *

Drive strategic alliances and partner-led transformations, shaping go-to-market strategies. Collaborate across teams and foster executive relationships to enhance technology offerings and business gro...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$100K - $125K *

Join our dynamic finance team as you drive margin and profitability through detailed analysis and strategic insights. Collaborate with senior leadership to transform data into actionable initiatives t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$137K - $182K *

Architect and drive AI-powered applications for drug development, focusing on protocol generation and clinical trials. Lead technical direction, mentor engineers, and ensure compliance while fostering...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$101K - $135K *

Join a team that's shaping the future of healthcare technology by designing and enhancing our build and delivery infrastructure. Collaborate with architects and developers to implement best practices...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Accelerate growth by building a new region from scratch, driving sales, and establishing customer success stories for a groundbreaking FinOps solution. Own the full sales cycle, focusing on net-new lo...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$77K - $202K *

Unlock potential by implementing CGI OpenGrid solutions, analyzing client needs, and guiding junior team members. Drive operational efficiency through technical expertise and build strong client relat...

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$100K - $120K *

Drive budget management and project support for public health initiatives, ensuring accurate tracking, analysis, and reporting. Collaborate with leadership to enhance operational efficiency in a dynam...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$240K - $330K *

Transform autonomous driving evaluation by leading initiatives that bridge model performance and real-world outcomes. Collaborate with cross-functional teams to develop metrics and tools that enhance...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Transportation

$80K - $106K *

Transform your career by partnering with us to enhance investment operations. As a key player, you'll manage private credit transactions, ensuring accurate accounting and reporting while driving proce...

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$88K - $98K *

Join a team that's shaping the future of paid social strategy for top consumer brands. Drive growth through innovative, data-driven campaigns on platforms like Meta, TikTok, and YouTube, while mentori...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.