Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.
Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.
Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.
Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.
Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.
Senior Software Engineer, Python
$170K - $200K *
Advance backend solutions and frontend features, collaborating across teams to build scalable systems and AI integrations, driving product growth from conception to execution...
Reposted today
Sr. Manager, Analyst Relations
$165K - $190K *
Advance your career by shaping analyst relations and market perception in AI and automation. Collaborate with cross-functional teams to drive impactful evaluations and strategic narratives that enhanc...
2 weeks ago
Engineering Manager, Governance & Access
$150K - $180K *
Empower our team to build innovative security and governance solutions, shaping access management for both human and agent users. Lead a small, dynamic group as we define architectural foundations and...
3 weeks ago
$120K - $145K *
Drive the design and development of innovative software solutions while mentoring junior engineers. Leverage extensive technical expertise to enhance system architecture and ensure high-quality delive...
1 week ago
Technical Content Developer Associate Manager, AI POD
$73K - $182K *
Transform the future of AI learning by developing engaging, hands-on technical content that empowers adult learners to master machine learning and AI applications, ensuring instructional quality and t...
Yesterday
Technical Content Developer Associate Manager, AI POD
$73K - $182K *
Create impactful AI learning experiences by developing courses, labs, and assessments. Collaborate with experts to ensure technical accuracy and instructional quality, enabling learners to apply AI sk...
2 days ago
Product Manager, National Center for Clinical Trials (NCCT)
$122K - $183K *
Transform how we operate by leading technology-driven initiatives that enhance business capabilities. Collaborate with cross-functional teams to define product strategies and drive measurable outcomes...
5 days ago
$85K - $95K *
Engage in the development and execution of automated testing strategies, ensuring software quality through comprehensive test plans and scripts. Collaborate with teams to maintain CI/CD pipelines and...
6 days ago
$80K - $92K *
Drive the resolution of technical support escalations as a key Tier 2 expert, leveraging your skills to troubleshoot issues, foster collaboration within teams, and enhance workflows in a dynamic envir...
Reposted 6 days ago
Senior Software Engineer, Observability
$120K - $145K *
Champion the development of innovative observability solutions, leveraging your expertise in Go and network protocols to enhance network automation. Collaborate with cross-functional teams to deliver...
1 month ago
$120K - $145K *
Engage in technical leadership and project management to develop industry standards and reports. Collaborate with working groups to drive best practices and support continuous improvement initiatives...
2 weeks ago
$350K *
Engage with key enterprise clients to drive revenue growth through strategic, solution-based sales. Develop lasting relationships and navigate complex sales processes while championing company values...
Reposted 4 days ago
Senior Engineering Manager, AI Platform
$150K - $180K *
Lead and develop a high-performing Applied AI team, driving the delivery of production AI systems while ensuring security, reliability, and operational excellence in healthcare applications...
Yesterday
Business Insights Analyst, Remote US
$80K - $95K *
Grow your career with a dynamic role that drives actionable insights across e-commerce and service delivery. Collaborate with stakeholders to analyze data, build impactful reports, and enhance busines...
2 weeks ago
$100K - $120K *
Elevate your career by designing and optimizing EpicCare Ambulatory workflows. Collaborate with clinicians to enhance EHR functionality, troubleshoot issues, and ensure seamless operations across heal...
1 week ago
GIS Software Quality Assurance Engineer
$95K - $120K *
Elevate software quality assurance by testing GIS applications and validating complex datasets. Collaborate with developers and GIS specialists to ensure accuracy and reliability in geospatial data fo...
2 weeks ago
$86K - $144K *
Unlock potential by leading the design and development of scalable generative AI services, ensuring architectural integrity and mentoring teams. Collaborate with cross-functional stakeholders to drive...
Reposted 2 weeks ago
Senior Responsible AI Researcher
$150K - $180K *
Lead groundbreaking research in AI safety and evaluation, bridging academic rigor with real-world challenges. Drive innovative methodologies and collaborate with top-tier institutions to enhance respo...
2 weeks ago
Staff Software Engineer, Growth (Self Serve)
$150K - $180K *
Shape impactful customer journeys as a Staff Software Engineer, leading technical initiatives and collaborating across teams to enhance product capabilities and drive growth. Your expertise will influ...
2 days ago
$120K - $145K *
Take ownership of automating workflows across teams by building AI agents using Claude and Microsoft Copilot. Collaborate with various departments to identify automation opportunities, ensuring securi...
3 weeks ago
Senior Cloud Security Engineer
$135K - $160K *
Accelerate progress at securing cloud environments by designing robust guardrails and automation. Collaborate with engineering teams to embed security into CI/CD pipelines and ensure compliance across...
2 weeks ago
Principal Mechanical R&D Engineer
$110K - $130K *
Empower innovation by leading upstream R&D efforts to transform clinical needs into prototypes and technical evidence. Collaborate with cross-functional teams to drive projects from concept to clear i...
Yesterday
$110K - $130K *
Empower our engineering teams by leading technical recruitment efforts. Dive deep into candidate sourcing, build strong pipelines, and enhance the hiring process while ensuring a positive candidate ex...
1 week ago
Lead Enterprise Revenue Architect (Customer Success)
$148K - $225K *
Join a team that's transforming revenue operations through AI-driven insights. You'll collaborate with senior leaders, architect workflows, and drive adoption to ensure measurable business outcomes ac...
Reposted 4 weeks ago
Commercial CRM Business Analyst- Salesforce
$110K - $130K *
Partner with us to drive commercial CRM solutions for pharma, leading requirements gathering and process design. Collaborate with stakeholders to ensure effective system implementation and user adopti...
1 week ago
What kinds of $100,000+ jobs are available in Iowa?
Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.
Which Iowa cities have professional jobs listed?
Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.
Are all jobs on this page guaranteed to pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.
How can I find the right high-paying job in Iowa?
Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.