Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$138K - $165K *

Transform AI capabilities by building robust SDKs and infrastructure. Collaborate with product teams to enhance agent workflows, ensuring reliability and performance while driving innovation in AI exp...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Shape the future of quality assurance by leading automated testing initiatives for cloud-based ERP systems, ensuring seamless integration and performance across various business processes and upgrades...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$115K *

Join a team that's dedicated to driving sales success through lead generation and client education. This role involves delivering impactful product demonstrations and collaborating with sales teams to...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$269K - $370K *

Join a team that's transforming AI into a measurable business capability. Lead strategic initiatives, optimize operations, and collaborate across functions to enhance AI adoption and efficiency while...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Information Technology

$230K - $345K *

Lead the charge in database excellence to enhance reliability, performance, and sustainability of GitLab's datastores. Shape long-range strategies while collaborating across teams to drive success in...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Advance your career by leading consultancy projects, managing workstreams, and enhancing client relationships. Contribute to business growth through strategic development and deliver impactful client...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead the charge in transforming public sector consulting by guiding organizations through digital transformation and ERP implementations, while managing high-impact teams and fostering client relation...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$134K - $180K *

Shape the future of nonprofit technology by leveraging your expertise to empower mission-driven organizations with innovative Salesforce solutions and strategic insights...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Join a team that's redefining data architecture by leading innovative modeling and integration initiatives. Collaborate with AI Engineers to create scalable datasets and optimize performance in a mult...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Transform the future of financial freedom by leading full-cycle recruiting for Product Management roles. Collaborate with leaders to shape hiring strategies and enhance candidate experiences, driving...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $136K *

Join a team that's redefining customer experience by translating complex business needs into actionable technical requirements, ensuring seamless integration across platforms and delivering innovative...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Drive innovation by enhancing CI/CD systems for ML models, automating testing and deployment processes. Collaborate with teams to streamline workflows, reduce manual tasks, and ensure reliable model r...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $270K *

Unlock your potential as a Research Scientist, driving AI innovations in healthcare. Collaborate with cross-functional teams to develop and implement cutting-edge machine learning models that enhance...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Champion systems engineering efforts for a Navigation and Positioning project, collaborating with cross-functional teams to ensure compliance with DO-278 guidelines while enhancing system integrity an...

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$113K - $188K *

Join a dynamic team to design and develop high-performance ETL solutions, integrating data from diverse sources. Collaborate with cross-functional teams to optimize data workflows and ensure complianc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$160K - $230K *

Join a team that's redefining product engineering by owning high-impact areas from concept to launch. Collaborate closely with leadership to enhance user experiences and drive innovation in a fast-pac...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Take ownership of software engineering initiatives within established companies. Lead teams, modernize development processes, and enhance code quality while delivering impactful software solutions. Co...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$238K - $280K *

Lead the charge in developing autonomous attack workflows for external surfaces, leveraging your expertise to enhance reconnaissance capabilities and mentor engineers while driving strategic technical...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Join a pioneering team to build an AI-enabled care delivery platform, bridging clinical expertise and engineering to create safe, effective patient care solutions. Drive innovation from concept to pro...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in securing and optimizing OT/ICS networks for energy systems. As a senior engineer, you'll design network architectures, manage cybersecurity compliance, and collaborate with cross-fu...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $375K *

Join a dynamic team as you own the digital-brain methodology, asset portfolio, and technical perspective in your industry, driving innovation and engagement through advanced data products and AI use c...

1 week ago

  •   11 - 15 years exp.  •   Business Services

$87K - $230K *

Empower enterprises by designing and delivering AI solutions that drive transformation. Lead cross-functional teams, manage client relationships, and ensure quality in production deployments while sha...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$125K - $132K *

Champion the design of agent-ready workflows by translating complex business processes into clear requirements. Collaborate with product teams to enhance AI capabilities and ensure seamless human-agen...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$231K - $340K *

Partner with us to drive sales of innovative cybersecurity solutions, cultivating strong client relationships and exceeding quotas in the TOLA territory. Leverage your expertise to deliver impactful s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $150K *

Unlock potential by driving AI deployment strategies with clients, translating business needs into actionable use cases, and ensuring successful model adoption. Collaborate closely with engineers and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.