Job Description

General Summary:

The Stem Cell Research Scientist works with some independence and is adept at conceptually outlining studies to design and execute focused research projects or a series of complex experimental procedures including the development of human hematopoietic cell models and assays to evaluate targets and lead molecules for Vertex diseases. Completes work in a resourceful, self-sufficient manner and is able to design alternative approaches to achieve desired outcomes. Keeps current on the scientific literature relevant to scientific methodology or field(s) of technical expertise. This level captures both the Research organization's entry level for staff with a research doctoral degree (PhD) and the advanced experimental expert leading one or more critical laboratory functions with high impact on drug discovery projects.

Key Duties and Responsibilities:

• Designs and conducts elaborate, conceptually connected, multi-component in vitro and ex vivo experiments with primary hematopoietic cells and cell lines
• Collates and interprets data systematically, and synthesizes results into a cohesive body of conclusions or recommendations to guide Project decisions and new research activities
• Exercises solid judgment to prioritize studies, considering feasibility and Project impact
• Performs advanced experimental troubleshooting
• Scours relevant scientific literature and routinely incorporates new insights into research activities
• Identifies, prioritizes and introduces relevant emerging technologies in field of expertise to advance the existing technology platforms and create/maintain a competitive advantage
• Explores the feasibility of applying new scientific principles/concepts or implements and validates new experimental approaches and technologies to achieve project goals
• Contributes to patent and/or publication preparation
• Independently prepares study presentations and presents experimental conclusions at internal Group/Department or Project Team research meetings
• Performs other duties as assigned

Knowledge and Skills:

• Ability to design and execute complex experiments including the development of human hematopoietic cell assays to evaluate targets and lead molecules for Vertex diseases
• Must have hands-on experience working with primary human hematopoietic cells and have experience developing and running multicolor flow cytometry and cell-based functional assays
• Experience with gene editing techniques
• Demonstrates astute understanding of own discipline and the relevant literature
• Maintains a high level of knowledge related to current developments in the scientific Project field
• Displays proven productivity and experimental creativity, and effective dissemination of ideas
• Demonstrates effective, self-sufficient communication skills, especially in peer-directed presentations
• Demonstrates awareness of other Project-related disciplines and an understanding of general concepts and some experimental detail within those areas

Education and Experience:

• Ph.D. (or equivalent degree) in molecular and cell biology, developmental biology, stem cell biology, or related disciplines and 0-3 years of relevant post-doctoral employment experience, or
• Masters Degree (or equivalent degree) in molecular and cell biology, developmental biology, stem cell biology, or related disciplines and 3+ years of relevant employment experience, or
• Bachelors Degree (or equivalent degree) in molecular and cell biology, developmental biology, stem cell biology, or related disciplines and 6+ years of relevant employment experience

Pay Range:
$104,200 - $156,200

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:
On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

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