The Nelson research group (https://research.fredhutch.org/peternelson/en.html) at the Fred Hutch Cancer Center is seeking a highly motivated Staff Scientist to take the lead on multiple projects focused on aspects of androgen receptor (AR) biochemistry and pathobiology in prostate cancer.

• Designing and conducting experiments involving determining mechanisms of AR activity in prostate cancer
• Designing and conducting experiments that identify pathways and drugs that exploit AR signaling pathways in cancer and benign cells.
• Designing and conducting genetic and small molecule screens for vulnerabilities in models of advanced prostate cancer.
• Performing bioinformatics and statistical analyses of public and private datasets of gene expression and genomics in advanced prostate cancer.
• Develop independent research projects suitable for external funding proposals
• Document experimental research in appropriate format for presentations, publications, and grant proposals.
• Assist the Principal Investigator with projects, supervising, training, and mentoring members of the laboratory.

MINIMUM QUALIFICATIONS:

• Doctoral degree or equivalent in biology, biochemistry, molecular biology, pharmacology, immunology or genetics.
• Post-doctoral or research experience in a field relating to oncology: endocrinology, genomics, genetics, metastasis, drug and gene delivery systems, immunology, immunotherapy.
• Evidence of independent research, including publications in peer-reviewed journals and successful grant funding.
• Experience in supervisory and project management in an academic or biotechnology setting.
• Capacity to develop new research techniques and adapt to a fast-paced environment.
• Excellent verbal and written communication skills.

PREFERRED QUALIFICATIONS:

• Experience performing standard cell, histology, and molecular biology techniques including RNAseq and ChIPseq.
• Experience working with in vivo systems, including genetically modified and syngeneic mouse tumor models.
• Experience with rapid screening of new technologies intended to enhance drug and biologics delivery.
• Experience in the development and characterization of genetically engineered mouse models.
• Ability to work in a cross-functional environment with engineers, biologists, and medical doctors.
• Development of protocols (e.g. IACUC and IRB), work plans for externally funded research agreements, and experience writing and submitting research grants to funding agencies.

The annual base salary range for this position is from $84,406 to $191,755, and pay offered will be based on experience and qualifications.Although Fred Hutch is not sponsoring most H-1B visas at this time, candidates who already hold an H-1B sponsored by another organization and are currently in the U.S. may be eligible for this position.Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (up to 13 days per year), and paid parental leave (up to 4 weeks).