Pfizer

Staff Engineer High Performance Computing

Pfizer$124K — $207K *
Information Technology
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • B.S. in computer science, life science, data science, or related field with 6+ years of cloud infrastructure engineering experience.
  • Proven experience developing and supporting HPC frameworks in cloud environments.
  • Expertise in at least one of AWS or GCP, including relevant compute and storage services.
  • Thorough understanding of CI/CD practices and monitoring for cloud-based HPC infrastructure.
  • Strong knowledge of distributed systems and production system reliability.
  • Familiar with monitoring frameworks like CloudWatch and Grafana.
  • Solid grasp of cloud networking, identity, security, and core services.

Responsibilities

  • Lead development and operationalize cloud-based HPC infrastructure for research and data processing.
  • Serve as a technical expert to evaluate and advocate for technology platforms for HPC service delivery.
  • Collaborate with stakeholders to create a long-term technical roadmap for HPC services.
  • Conduct discussions with technical partners to define HPC requirements for cloud services.
  • Foster a culture of excellence and shared ownership through mentoring and coaching team members.
  • Design robust, scalable infrastructure for HPC and ML/AI workloads in cloud environments.
  • Drive infrastructure automation with IaC tools and establish lifecycle management procedures.

Benefits

  • 401(k) plan with Pfizer matching contributions and retirement savings contributions.
  • Paid vacation, holidays, and personal days.
  • Paid caregiver, parental, and medical leave.
  • Comprehensive health benefits including medical, dental, and vision coverage.
  • Access to wellness programs to support healthy living.
Full Job Description

ROLE SUMMARY

Pfizer is committed to the application of computational science in the areas of drug discovery and development and has recently initiated a large-scale migration of computational infrastructure to cloud. This role provides technical vision and will drive the execution of high-performance computing (HPC) solutions that support computational workloads across the organization. 

 

We are seeking an experienced individual to lead the technical architecture of the cloud HPC platform.  Key responsibilities include establishing go-forward cloud HPC platform computing technologies, implementing robust engineering practices, championing infrastructure as code (IaC), and configuring core services that support HPC at scale in the cloud environment. You will work with HPC engineers and scientific computing specialists to develop robust, scalable, high-performance cloud native infrastructure that underpins modernization of the scientific computing platform.

 

ROLE RESPONSIBILITIES
 

Strategic Leadership

This role will lead development and operationalize cloud-based HPC infrastructure required for research, modeling, and large-scale data processing across multiple cloud environments.

  • Serve as a primary technical expert; evaluate, advocate for, and drive consensus among senior managers and engineers for the go-forward technology platforms and toolkits used for HPC service delivery.
  • Collaborate with stakeholders, users, and leaders to develop a long-term technical roadmap for cloud-based HPC services.
  • Lead deep-dive discussions with technical partners at major cloud providers, defining HPC-related requirements and deliverables for Statements of Work.
  • Drive a culture of shared ownership, transparency, and engineering excellence through mentoring, coaching, and example setting. 
  • Perform troubleshooting, system analysis, and benchmarking to manage escalated, difficult to resolve issues and maintain a high-performance environment.


HPC Platform Architecture and Engineering

  • Design and own robust and dependable high-throughput, parallel, low-latency infrastructure for HPC and ML/AI workloads in multiple cloud environments (AWS/GCP).
  • Establish technical standards, best practices, architectural frameworks, and implementation guidelines for reproducible HPC platform and application deployments. 
  • Recommend cutting-edge HPC technologies including specialized accelerators, novel storage solutions, managed services, and open-source toolkits that will be integrated into the platform.
  • Own OS image development, job scheduler configuration, high performance storage systems
  • Ensure high performance, reliability, scalability, cost efficiency, and security.

 

Automation and DevOps

  • Drive adoption of infrastructure automation using IaC tools like Terraform and CloudFormation.
  • Establish, promote, and enforce internal standards (naming, tagging, documentation, version control, and change procedures) to ensure repeatable environment provisioning and scaling.
  • Establish infrastructure lifecycle management procedures, from provisioning to operations, support, updating, and teardown of production computing platforms.

 

Monitoring and Reliability

  • Determine KPIs to guide monitoring, logging, and alerting strategies for the infrastructure.
  • Collaborate with stakeholders, users, and senior managers to develop meaningful user-facing dashboards, drive resource management, cost efficiency, and workload optimization. 
  • Design workflows, alerting systems and utilities to improve observability, user, or administrator experiences.

 

BASIC QUALIFICATIONS

  • B.S. in computer science, life science, data science or similar fields with 6+ years of experience in cloud infrastructure engineering.
  • A proven track record of developing and supporting robust HPC frameworks in a cloud environment.
  • Expert level experience with at least one of AWS and GCP, including knowledge of core compute and storage services relevant to HPC.
  • Deep understanding of modern CI/CD practices, observability and monitoring of cloud-based HPC infrastructure.  
  • Strong knowledge of distributed systems and production system reliability.
  • Familiarity with monitoring and observability frameworks (CloudWatch, Prometheus, Grafana, etc.)
  • Solid understanding of cloud networking, identity, security controls, and core services.

 

PREFERRED QUALIFICATIONS

  • M.S. in computer science, life science, data science or similar fields.
  • 10-15 years experience in HPC/Cloud engineering
  • Expertise with distributed computing environments, especially EKS/GKE/Kubernetes
  • Deep experience with HPC environments, job schedulers, and NVIDIA GPU compute.
  • Prior experience with HPC deployment utilities including AWS ParallelCluster and Parallel Computing Services, and Google Cloud Cluster Toolkit
  • Familiarity with other aspects of managing HPC services in a cloud environment: cloud financial models, cost optimization, user support services, application delivery, Linux administration, job scheduling, resource optimization.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Occasional travel may be required


Work Location Assignment: Hybrid

The annual base salary for this position ranges from $124,400.00 to $207,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Information & Business Tech

About Pfizer

Hospira, Inc. is the provider of injectable drugs and infusion technologies. Through its broad, integrated portfolio, Hospira is uniquely positioned to Advance Wellness™ by improving patient and caregiver safety while reducing healthcare costs. The company is headquartered in Lake Forest, Ill., and has approximately 16,000 employees.

Pfizer Careers

Joining Pfizer’s global team offers more than just job opportunities; it’s a chance to be a part of a company that leads with science and innovates for better health. As a leading biopharmaceutical company, Pfizer is at the forefront of transforming lives through innovation, leadership, and diversity. Work You’ll Do At Pfizer, you will collaborate with some of the brightest minds in the industry, engaging in work that enhances global health and saves lives. Our culture thrives on intellectual curiosity, professional growth, and inclusivity, making every day a learning opportunity. Here, your skills will be honed, your professional acumen will be expanded, and you will be part of a team that values the power of diverse insights to drive success. Pfizer’s Leadership and Growth Lead and innovate with Pfizer, where we value the growth of each employee. Our leadership is committed to providing employees with the training and resources needed to excel in their careers. Pfizer offers a variety of career paths, including roles in research, marketing, finance, technology, and more, each offering a unique blend of challenges and rewards. Internship and Employment Opportunities Start your career with Pfizer through our internship programs or dive straight into a full-time position. We are hiring individuals who are passionate about healthcare and who seek to make a difference in the world. Our internships provide invaluable industry experience, networking opportunities, and a potential pathway to full-time employment. Benefits and Culture Pfizer is dedicated to fostering a workplace where all employees feel valued and can achieve their full potential. We offer competitive benefits packages that support the health, well-being, and financial security of our employees and their families. At Pfizer, you’ll find a culture that encourages collaboration, innovation, and continuous learning. Join Our Team Explore the numerous job opportunities at Pfizer by searching open positions that match your skills and interests. We look for driven, curious, and innovative team players who are ready to advance their careers in a transformative company. Stay Connected Keep up to date with career tips, insider perspectives, and industry-leading insights you can put to use today—all from the people who work here. Personalize your subscription to receive job alerts, latest news, and insider tips tailored to your preferences. Discover the exciting and rewarding career opportunities that await at Pfizer. Interview and Resume Tips Prepare for your future with Pfizer by utilizing our resources for resume building and interview preparation. We provide guidance on how to effectively showcase your skills and experiences to align with the needs of a position at Pfizer. Our goal is to help you succeed in securing a role that suits your professional goals and personal growth aspirations. Pfizer: A Place Where You Can Make a Difference Every position at Pfizer contributes to our mission of making the world a healthier place. Whether through direct patient care, research innovation, or corporate roles that support our operations, your work will have global impact. Join us in our journey to change lives—explore Pfizer careers today.
Learn more about Pfizer
Size
79,000 employees
Market Cap
$285.9 billion
Industry
Net Income
$9.6 billion
Founded
1849
5 Year Trend
+9%
Revenue
$41.9 billion
NASDAQ

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