The Charles Stark Draper Laboratory

Sr. Intestinal Tissue Engineer

Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's Degree in relevant fields required; PhD preferred.
  • 5+ years of experience in bioengineering or related fields.
  • Strong foundation in biology and engineering principles.
  • Expertise in human intestinal cell culture and organ-on-chip technology.
  • Excellent communication and problem-solving skills.
  • Strong organizational and time management skills.

Responsibilities

  • Drive interdisciplinary solutions to complex bioengineering problems.
  • Develop and optimize microphysiological systems and organ-on-chip models.
  • Conduct and lead technical experiments in a BSL-2 laboratory.
  • Mentor junior bioengineers and provide constructive feedback.
  • Collaborate with multidisciplinary teams to execute project plans.
  • Analyze data and present findings to stakeholders.
  • Contribute to business development and proposal writing efforts.

Benefits

  • Strong emphasis on work-life balance and workplace flexibility.
  • Supportive team culture and a focus on career development.
  • Opportunities for mentorship and collaboration.
  • Participation in employee clubs and social events.
  • Access to health and finance workshops.
Full Job Description
Job Description Summary:
The Bioengineer (SMTS) is focused on developing and deploying multidisciplinary solutions at the convergence of biology and engineering to address critical needs in national security and healthcare while fostering a thriving culture and developing the next generation of innovators. The Bioengineer will apply their foundational knowledge and experience to a broad range of interdisciplinary efforts. Our culture fosters innovation, a supportive team environment, intellectual freedom and creativity, and an emphasis on career development. Duties are performed with limited supervision.

Job Description:

Duties/Responsibilities
  • Drive solutions to complex problems with limited direction.
  • Contribute to the development of innovative bioengineering solutions, propose ways forward, and adapt appropriately to changes in requirements.
  • Able to provide insight and suggest design modifications based on analysis outcomes.
  • Actively mentor less experienced bioengineers and provide thoughtful, constructive feedback.
  • Performs other duties as assigned.


Skills/Abilities
  • Strong foundation in biology and/or engineering principles.
  • Team player, dedicated, collaborative, observant, and motivated.
  • Excellent organizational skills, attention to detail, and verbal and written communication skills.
  • Creative problem-solving skills and a passion for innovation.
  • Excellent time management skills with the proven ability to meet deadlines and prioritize tasks.
  • Enthusiasm for learning and participating in mentorship/mentoring.
  • Proficiency with Microsoft Office Applications.


Education
  • A minimum of a Bachelor's Degree in Bioengineering, Biomedical Engineering, Biochemistry, Chemistry, Cell Biology, Immunology, Microbiology, Molecular Biology, Mechanical Engineering, Chemical Engineering, Physics or related fields is required, a PhD is preferred.


Experience
  • Requires 5+ years of Bioengineering or related engineering experience.


Additional Job Description:

Additional duties/responsibilities:
  • Develop, optimize, and characterize intestine microphysiological (MPS) and organ-on-chip models for toxicity, permeability, and disease-state studies
  • Apply cell biology, developmental biology, and tissue engineering fundamentals to establish cell and tissue-based assays within Draper's in vitro tissue culture systems under a variety of use-case scenarios
  • Plan, conduct, and lead technical experiments with Draper's advanced in vitro tissue culture technologies (microphysiological system or organs-on-chip) in a BSL-2 laboratory
  • Culture, maintain, and manipulate human primary cells and tissues - specifically propagating human intestinal organoids and isolating and differentiating human monocytes
  • Perform a broad suite of molecular, biochemical, and cellular assays (e.g. immunostaining, ELISA, Luminex, flow cytometry, DNA and RNA extraction, qPCR, multi-omics) and biostatical data analysis
  • Acquire brightfield, fluorescent and high-content confocal microscopy data; process and analyze image sets within automated pipelines to extract quantitative biological insights
  • Create, version control, and maintain SOPs and analytical methods that are fully compatible within Draper's platform technologies
  • Collect, interpret, and summarize data; deliver clear and concise presentations to project leads, internal management, external sponsors/customers, and for peer-reviewed publication
  • Collaborate across multidisciplinary teams to execute project plans; mentor and train bench-level colleagues and foster a collaborative, safety-first lab culture.
  • Troubleshoot experimental challenges in partnership with teammates and project leadership; drive rapid, data-backed decisions to keep projects on schedule
  • Complete all required training, adhere to institutional, governmental, and safety regulations, and champion an environment of compliance
  • Contribute to business-development activities - technical ideation, proposal writing, and customer outreach - to expand Draper's tissue engineering portfolio
  • Support day-to-day lab organization (reagent sourcing, material preparation, equipment upkeep) to keep the MPS workflow running smoothly
  • Work in face-paced, milestone-driven interdisciplinary environment where multi-tasking is essential


Preferred qualifications:
  • Education & Experience: PhD in biology or engineering discipline with ≤ 3 years of post-doctoral or industry R&D experience, or MS in biology or engineering discipline with ≥ 5 industry R&D experience
  • Proven Intestine-specific expertise: Demonstrated ability to isolate, propagate and assay human intestinal stem cells as organoids and monolayer tissues.
  • Human immune cell culture expertise: Demonstrated knowledge and ability to isolate and differentiate human immune cells
  • Advanced in-vitro system fluency: Proven experience with microfluidic-based cell and tissue culture platforms (e.g., microphysiological systes (MPS), organ-on-chi
  • Broad technical breadth: Some experience with microbiology (viruses, bacteria, toxins), immunology, synthetic biology, genetic engineering, bioinformatics/data analytics, and/or in silico modeling; some experience with bio-informatic pipelines for high-content image and omics integration (e.g. R/Python); familiarity with lab-automation for routine laboratory workflows
  • Strong communication skills: Ability to convey complex biology concepts to engineers, data scientists, and senior management; experienced in multi-disciplinary teamwork
  • Proposal development: Experience writing innovative R&D proposals for government sponsors (contracts, grants) and secure external funding
  • Professional skills: Demonstrated ability to work independently while thriving in a collaborative environment; demonstrated flexibility to multi-task, adapt to shifting priorities and thrive in a fast-moving, collaborative environment; prior involvement in industry-academic consortia, clinical collaborations, and/or successful track-record of securing external funding; experience generating high-impact liver-focused scientific manuscripts or patent(s)


Security Requirement: Applicants selected for this position will be required to obtain and maintain a government security clearance.

Job Location - City:
Cambridge

Job Location - State:
Massachusetts

Job Location - Postal Code:


The US base salary range for this full-time position is
$82,300.00 - $220,000.00
Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target salaries for the position across all US locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training. Union ranges will be in compliance with the collective bargaining agreement's approved rates by location and role. Your recruiter can share more about the specific salary range for your preferred location during the hiring process. Please note that the compensation details listed in US role postings reflect the base salary only, and does not include bonuses or benefits.

Our work is very important to us, but so is our life outside of work. Draper supports many programs to improve work-life balance including workplace flexibility, employee clubs ranging from photography to yoga, health and finance workshops, off site social events and discounts to local museums and cultural activities. If this specific job opportunity and the chance to work at a nationally renowned R&D innovation company appeals to you, apply now www.draper.com/careers.

About The Charles Stark Draper Laboratory

Draper Laboratory is an American non-profit research and development organization, headquartered in Cambridge, Massachusetts; its official name is The Charles Stark Draper Laboratory, Inc. The laboratory specializes in the design, development, and deployment of advanced technology solutions to problems in national security, space exploration, health care and energy. The laboratory was founded in 1932 by Charles Stark Draper at the Massachusetts Institute of Technology to develop aeronautical instrumentation, and came to be called the MIT Instrumentation Laboratory. During this period the laboratory is best known for developing the Apollo Guidance Computer, the first silicon integrated circuit based computer. It was renamed for its founder in 1970, and separated from MIT in 1973 to become an independent, non-profit organization. The expertise of the laboratory staff includes the areas of guidance, navigation, and control technologies and systems; fault-tolerant computing; advanced algorithms and software systems; modeling and simulation; and microelectromechanical systems and multichip module technology.
Learn more about The Charles Stark Draper Laboratory

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