Roche

Senior Translational Scientist, Oncology Biomarkers & Translational Research

Roche$120K — $224K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • PhD in Cancer Biology, Molecular Biology, Immunology, Genomics, Bioinformatics, Computational Biology, or related field.
  • 3+ years of experience in translational oncology research or postdoctoral training.
  • Strong understanding of tumor profiling technologies like genomic, proteomic, and liquid biopsy.
  • Experience in translational study design focusing on assay selection and quality control.
  • Ability to collaborate across biology, clinical, laboratory, and computational teams.
  • Expertise in one oncology therapeutic area, such as breast or lung cancer.

Responsibilities

  • Co-design translational research strategies targeting oncology programs.
  • Utilize large-scale patient cohorts and biospecimens to generate insights.
  • Identify disease states, resistance mechanisms, and potential biomarkers.
  • Champion emerging profiling technologies and data approaches.
  • Lead biomarker study design, ensuring scientific and technical feasibility.
  • Collaborate with multidisciplinary teams to translate findings into actionable hypotheses.
  • Communicate insights and strategic recommendations to diverse teams.

Benefits

  • Discretionary annual bonus based on performance.
  • Health and wellness benefits.
  • Retirement savings plan options.
  • Opportunities for professional development and continuing education.
Full Job Description

We are seeking an exceptional translational scientist to help shape the next generation of precision oncology. This role sits at the intersection of translational biology, emerging profiling technologies, clinical development, and computational science, with a focus on uncovering novel disease biology from large-scale patient datasets and clinical trial biospecimens.

The successful candidate will design innovative translational research strategies that integrate multimodal molecular profiling, clinical data, and advanced computational approaches to generate actionable biological insights. Working closely with computational biologists, statisticians, and AI/ML scientists, this individual will help identify novel disease states, resistance mechanisms, biomarkers, and patient populations that may inform future oncology treatments.

This role offers a unique opportunity to leverage large-scale patient cohorts, clinical trial biospecimens, and emerging technologies to address previously intractable questions in cancer biology. The successful candidate will play a key role in translating biological questions into fit-for-purpose data generation strategies and partnering across disciplines to transform complex multimodal datasets into insights that influence biomarker strategies, patient stratification, and future therapeutic development.

This role is ideal for a scientist who is excited by scientific discovery, technology innovation, and the opportunity to combine biology and data science to advance precision medicine for patients.

Key Responsibilities

  • Co-design translational research strategies that address key biological and clinical questions across oncology programs.

  • Leverage large-scale patient cohorts, clinical trial biospecimens, and multimodal datasets to generate molecule-specific, mechanism-specific, and disease-specific insights.

  • Identify novel disease states, resistance mechanisms, biomarkers, and patient populations that may inform future oncology treatments.

  • Evaluate and champion emerging profiling technologies, including genomic, spatial, proteomic, liquid biopsy, single-cell, multimodal, and AI-enabled approaches.

  • Guide tumor profiling and assay selection for correlative studies, balancing scientific objectives, sample constraints, technical feasibility, and clinical development needs.

  • Lead fit-for-purpose biomarker study design, including cohort selection, assay strategy, benchmarking, quality control, analytical workflows, and data interpretation.

  • Partner with biologists, laboratory scientists, computational biologists, statisticians, and AI/ML scientists to integrate data and translate findings into actionable hypotheses.

  • Contribute to biomarker plans, translational medicine strategies, study protocols, publications, scientific communications, and external collaborations.

  • Communicate scientific insights and strategic recommendations to multidisciplinary teams, clinical teams, and senior stakeholders.

Who You Are

  • PhD in Cancer Biology, Molecular Biology, Immunology, Genomics, Bioinformatics, Computational Biology, or a related discipline.

  • Postdoctoral training or 3+ years of relevant industry or academic experience in translational oncology research.

  • Strong understanding of current and emerging tumor profiling technologies, including genomic, spatial, proteomic, liquid biopsy, single-cell, or multimodal approaches.

  • Demonstrated experience with translational study design, including assay selection, technical benchmarking, quality control, analytical workflows, and biological interpretation.

  • Ability to work effectively across multidisciplinary teams spanning biology, clinical development, laboratory sciences, computational biology, statistics, and AI/ML.

  • Deep expertise in at least one oncology therapeutic area, such as breast, lung, colorectal, prostate, or hematologic malignancies.

Preferred Qualifications

  • Experience supporting translational research within academic, clinical or commercial settings

  • Experience with statistical modeling, biomarker analysis, or multimodal data integration.

  • Experience evaluating or implementing novel profiling technologies in translational or clinical research.

  • Experience in leveraging AI models and tools to support productivity

  • Track record of publications, presentations, or contributions to biomarker development or precision oncology programs.

The expected salary range for this position based on the primary location of California is $120,700 - $224,100 Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits..

Relocation benefits are not available for this position.

About Roche

Roche Holding AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has bearer shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the largest pharmaceutical company in the world, and the leading provider of cancer treatments globally. The company also produces a range of diagnostic tests for medical professionals and patients. Roche was one of the first companies to bring targeted treatments to patients. In 2019, Roche had over 100,000 employees worldwide, and generated revenue of CHF 61.5 billion.
Learn more about Roche
Size
100,920 employees
Industry
NASDAQ

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