Your Role:

Senior Research Scientist - Medicinal Chemist

As a Senior Research Scientist in Medicinal Chemistry, you will be an integral member of our small molecule drug discovery engine, contributing to the design, synthesis, and optimization of novel medicines for animal health. You will apply yourexpertiseto advance therapeutic programs by guiding Structure-Activity Relationship (SAR) studies and collaborating closely with a global, cross-functional team of scientists. Leveraging modern technologies like AI/ML and DNA-Encoded Libraries, you will help solve complex chemical challenges and make a meaningful impact on our discovery portfolio.This role offers a significant opportunity for growth as part of a dynamic and expanding research team.

Your Responsibilities:

• Guidethe design of novel small molecules and propel Structure-Activity Relationship (SAR) studies by integrating biological, pharmacological, and ADME/PK data into iterative design strategies.

• Manage and coordinate the synthesis, purification, and characterization of compounds with external Contract Research Organizations (CROs) and internal partners to ensuretimelyproject delivery.

• Apply advanced drug discovery technologies, including DNA-Encoded Libraries (DEL) and AI/ML-enabled molecular design tools, to accelerate hit identification and lead optimization.

• Collaborate as a key member of multidisciplinary project teams, partnering with scientists in Biology, Pharmacology, DMPK, Toxicology, and Computational Sciences to advance discovery programs.

• Maintainhigh standardsof experimental design, data integrity, and scientific documentation to support data-driven judgments across the discovery portfolio.

What You Need to Succeed (minimum qualifications):

• Education:PhD in Medicinal Chemistry, Organic Chemistry, or a relateddiscipline.

• Experience:A minimum of 3 years of industry experience in medicinal chemistry within a pharmaceutical, animal health, or crop science research environment.

• Top Skills:Demonstrated expertise in complex multi-step organic synthesis and modern medicinal chemistry, with a strong understanding of pharmacology and pharmacokinetics. Proven ability to collaborate effectively with cross-functional teams and manage external CRO partnerships to advance discovery projects.

What will give you a competitive edge (preferred qualifications):

• Postdoctoral experience.

• Experience with, or a strong interest in learning, advanced discovery technologies such as DNA-Encoded Libraries (DEL) and AI/ML applications.

• A track recordof contributing to small-molecule programs that have advanced into preclinical development.

• Prior experience in the animal health industry.

• Expertise inpeptide chemistry and optimization.

Additional Information:

• Travel:Less than 10%

• Location:Global Elanco Headquarters - Indianapolis, IN - Hybrid Work Environment

Don'tmeet every single requirement? Studies have shown underrecognized groups are less likely to apply tojobs unless they meet every single qualification. At Elanco we are dedicated to building a diverse and inclusive work environment. If you think you might be a good fit for a role but don'tnecessarily meet every requirement, we encourage you to apply. You may be the right candidate for this role or other roles!

Elanco Benefits and Perks:We offer a comprehensive benefits package focusing on financial, physical, and mental well-being while encouraging our employees to pursue our purpose! Some highlights include:

• Multiple relocation packages

• Two weeklong shutdowns (mid-summer and year-end) in the US (in addition to PTO)

• 8-week parental leave

• 9 Employee Resource Groups

• Annual bonus offering

• Flexible work arrangements

• Up to 6% 401K matching