Halozyme Therapeutics, Inc

Senior Principal Scientist 1

Halozyme Therapeutics, Inc$180K — $240K *
Pharmaceuticals & Biotech
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • Ph.D. in physiology, pharmacology, pharmaceutical sciences, or drug delivery; or master's with 15 years; or bachelor's with 20 years of experience.
  • 10 years of relevant industrial experience; equivalent combinations accepted.
  • In-depth knowledge of subcutaneous drug delivery with proven problem-solving skills.
  • Demonstrated expertise in conducting nonclinical in vivo studies.
  • Record of peer-reviewed publications involving preclinical models.
  • Preferred experience with medical devices like auto-injectors and on-body delivery systems.
  • Strong mathematical and data analysis skills.

Responsibilities

  • Lead and design in vivo nonclinical exploratory and preclinical drug delivery studies.
  • Collaborate with teams to analyze and interpret study data, preparing reports and summaries.
  • Ensure completion of studies to meet clinical goals for Halozyme and partners.
  • Draft and review regulatory documents like clinical trial protocols and drug administration instructions.
  • Develop models to advance drug delivery research and medical device knowledge.
  • Support research on novel drug delivery technologies to enhance business growth.
  • Drive innovation projects and contribute to scientific publications.

Benefits

  • Comprehensive benefit package including Employee Stock Purchase Program and 401(k) matching.
  • Opportunities for career advancement and educational growth through tuition reimbursement.
  • Collaborative work environment focused on innovation and impactful contributions.
Full Job Description
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How you will make an impact

The Senior Principal Scientist 1 is charged with leading, designing, conducting, and analyzing experimental work to support Halozyme's drug delivery platform, alliance collaborations, and device research. This position identifies and develops technical innovations to promote future business growth and improvements that meet Halozyme's and its partners' requirements. The Senior Principal Scientist 1 brings expertise in subcutaneous (SC) drug delivery and familiarity with preclinical models in both large and small animals. They engage with several Halozyme departments such as Product Development, Business Development, Device Development, and Intellectual Property Council. They also partner with Drug Delivery teams at alliances to lead discussions, compile and present data, attend meetings, and review clinical and regulatory materials as needed.

In this position, you'll have the chance to:
  • Plan, build, and conduct in vivo nonclinical exploratory and preclinical drug delivery studies to evaluate SC drug delivery and device technologies using Halozyme's drug delivery platforms.
  • Collaborate with platform teams to plan, build, conduct, analyze, and interpret data, and prepare nonclinical study reports and summaries to support drug delivery efforts.
  • Ensure successful completion of nonclinical studies to meet clinical needs for Halozyme and its alliance partners.
  • Support Halozyme's and its partners' regulatory filings by drafting and/or reviewing clinical trial study protocols, drug administration instructions, pharmacy manuals, and other regulatory documents.
  • Continue to develop experimental models to further expand drug delivery research and medical device development and knowledge.
  • Provide preclinical research support to assess novel or alternative drug delivery technologies to grow Halozyme's business portfolio.
  • Enable innovation and technical strategy projects, generate IP, and contribute to scientific publications.
  • Support multiple programs simultaneously in a fast-paced, global environment and drive project timelines based on project needs and input from Innovation colleagues and cross-functional teams.
  • Ensure compliance with company-established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards.
  • Participate in department and alliance team meetings.
  • Report and present scientific findings at appropriate scientific venues.
  • Strive to be a Halozyme subject matter expert in one or more drug delivery fields.
  • Provide leadership and set standards within the organization, driving toward a culture of quality, significant results, rapid delivery, collaboration, and Halozyme's core values.


To thrive in this position, you'll need:
  • A Doctoral (Ph.D. or equivalent experience) in a suitable subject area like physiology, pharmacology, pharmaceutical sciences, or drug delivery is needed. This must be paired with at least 10 years of relevant industrial experience. Candidates with a Masters (M.S. or equivalent experience) and 15 years or a BS (or equivalent experience) plus 20 years are also eligible.
  • An equivalent combination of experience and education may be considered
  • A strong background, in-depth knowledge, and hands-on technical ability in subcutaneous drug delivery. Proven problem-solving skills are a must. Expert knowledge of scientific principles and concepts.
  • Demonstrated technical proficiency, scientific creativity, collaboration with others, and independent thought.
  • Record of peer-reviewed publications involving preclinical models.
  • Expertise in crafting and conducting nonclinical in vivo studies is required.
  • Experience with medical devices, such as auto-injectors and on-body delivery systems, is preferred.
  • Experience with computer methods for data acquisition and analysis required.
  • Strong mathematical skills desired.
  • Exercise judgment and build procedures and practices to determine appropriate action.
  • Ability to communicate clearly and professionally both verbally and in written format.
  • Demonstrated leadership capabilities to develop a high-performing team, inspire change and influence internal and external collaborators.
  • Self-motivated, well-organized, with the ability to work independently and enjoy scientific investigation and thinking, proactively identifying issues, and developing solutions in a collaborative multidisciplinary environment.


In return, we offer you:
  • Full and comprehensive benefit program, including an Employee Stock Purchase Program and 401(k) matching.
  • Opportunities to advance in an environment that values learning, growth, and career progression through internal programs and tuition reimbursement.
  • A collaborative, innovative team that works as one to amplify your impact-on your career, the work you do, and patients' lives. Join us, and make a difference!


Environmental Conditions:

Physical Activities: On a continuous basis, be at a desk for a long period of time; intermittently answer the telephone and type on a computer. Some walking and lifting up to 20 lbs. may be required. The noise level in the work environment is usually low to moderate.

The physical requirements described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities of this job.

Laboratory Activities, if applicable: Biology and chemical laboratory environments experience needed. Environmental health and safety requirements also apply.

Travel:

Travel may be required up to 20% of your time.

The most likely base pay range for this position is $180,000 - $240,000 per year. Several factors, such as experience, tenure, skills, and particular business needs, will determine an individual's exact level of compensation. Base salary is only one element of employee compensation at Halozyme. Total compensation could include bonuses, sales incentives, and equity awards.

About Halozyme Therapeutics, Inc

Halozyme Therapeutics, Inc. is a biotechnology company focused on developing and commercializing novel oncology therapies that target the tumor microenvironment. The company's proprietary enzyme rHuPH20 is used to facilitate the delivery of injected drugs and fluids, potentially reducing the treatment burden of other drugs and improving patient convenience and compliance. Halozyme's lead investigational drug candidate, PEGPH20, is a PEGylated recombinant human hyaluronidase under clinical development for the treatment of pancreatic cancer and other solid tumors. The company was founded in 1998 and is headquartered in San Diego, California.
Learn more about Halozyme Therapeutics, Inc
Size
145 employees
Market Cap
$7.7 billion
Industry
Net Income
$129 million
Founded
1998
5 Year Trend
+24.8%
Revenue
$267.5 million
NASDAQ

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