Job Description

General Role Summary:

The Senior Director of Commercial Finance is a senior leader within theUSCommercial Finance organization and serves as the primary strategic business partner to the USCommercial Vice President and Business Unit Lead.This leader willpartner with the BU Lead todevelop options andguideresource allocation to balancegrowthandprofitability. This highly visible role leads a team responsible for strategicfinancial management,revenueforecasting, analytics,investment management,and value creation across thebusiness.

Key Duties and Responsibilities:

Strategic Leadership & Business Partnership

• Serve as thefinance business partnerto the USCommercial Vice President and Business Unit Lead, leading strategic decision support and shaping long term commercial strategyand execution

• Influence senior executives across Commercial, Medical, Human Resources, Global Finance, andCorporatefunctions to align financial plans with enterprise goals.

• Anticipate market, competitive, and regulatory dynamics andprovideactionable insights that guide commercial strategy and resource allocation.

Financial Strategy, Planning, and Performance Management

• Lead the annual budget, long range planning process, and monthly forecasting cycles for the USCommercialBU, ensuring integration with global planning frameworks.

• Oversee USrevenue and operating expense management and drive analytical rigor and scenario planning to support portfolio optimization and launch readiness.

• Identifyvalue drivers and enterprise risks and develop innovative, data driven solutions to enable profitable and sustainable growth.



Leadership, Culture, and Team Development

• Lead and develop a high performing team with capabilities aligned to Vertex leadership behaviors and culture.

• Build a culture of accountability, operational excellence, and continuous improvement across the Commercial Finance organization.

• Partner with HRon workforce planning and organizational design to support the growth of the USCommercial business.



Cross Functional Collaboration and Enterprise Influence

• Partner with Global Commercial Finance, Accounting, Tax,andInvestor Relationsto strengthen financial systems, processes, and communication.

• Drive alignment during key business cycles ensuring readiness for launches, lifecycle management, and competitive or market shifts.

• Represent USCommercial Finance in enterprise forums providing strategic, data driven perspectives that influence business direction.



Knowledge and Skills:

• Expert financial modeling, valuation, analytics, and scenario planning capabilities.

• Strategic thinker with the ability to translate complex information into useful insights for senior leaders.

• Exceptional executive communication and presentation skills.

• Ability to lead through ambiguity, drive organizational change, and innovate in afast pacedenvironment.

• Deep business acumen and understanding of the biotechnology market and commercial strategy.

• Demonstrated ability to lead teams and foster an inclusive,development orientedculture.

• Expertisewith Excel and PowerPoint and working knowledge of Hyperion or similar planning tools.



Education and Experience:

• Bachelors degree in Finance, Accounting, ora relatedfieldrequired. Master of Business Administration or other advanceddegreestrongly preferred.

• Fifteen or more years of progressive finance experience in commercial, FP&A, or strategic roles including experience supporting senior executives or an equivalent combination of education and experience. Demonstrated success leading financial strategy in a complex and highly regulated environment.

• Extensive experience in drug development, commercialization, launch planning, pricing, reimbursement, and USmarket access.

• Proven ability to influence executives and lead enterprise level initiatives.

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$212,000 - $318,000

Disclosure Statement:

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1.Hybrid: work remotely up to two days per week; or select
2.On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid