OverviewChenega Services and Federal Solutions, LLC., a
Chenega Professional Services' company, is looking for a
Senior Bacterial Core Technician to support bacteriology research, pharmacology studies, and laboratory operations within BSL-2 and BSL-3 research environments. The position supports in vivo and in vitro research programs through laboratory operations, animal studies, microbiological testing, pharmacokinetic and pharmacodynamic research, bioanalytical testing, data analysis, scientific reporting, and laboratory management activities. The incumbent assists with study design and execution, supports multidisciplinary research teams, maintains laboratory compliance and GLP requirements, contributes to scientific publications and technical reports, and serves as a technical resource supporting bacteriology research programs and animal studies.
Responsibilities- Responsible for BSL-3 laboratory operations and training in animal manipulations. Contract technicians shall perform approximately 5 animal studies in both the DTRA funded projects as well as contracted work.
- Perform in vitro Minimum Inhibition Concentration (MIC) testing of potential therapeutic compounds against Tier 1 bacteria. We currently utilize 30-strain diversity sets of Bacillus anthracis(anthrax), Yersinia pestis (plague), Francisella tularensis (tularemia), Burkholderia mallei (glanders), and Burkholderia pseudomallei (meliodosis), testing over 72 compounds per year against all 30 strains, in vitro.
- Participate in mouse, rat, rabbit, or other small animal studies, which include preparation of antibiotics for administration, administering drugs and vaccines, orally and by intraperitoneal, intramuscular, subcutaneous, and intravenous bolus injections. In addition, collect animal body fluids and remove tissues with all small animal studies executed. Upon execution of experiment all Contractors shall perform animal health exams to ensure study remains in compliance with IACUC approved protocols.
- Participate in weekly lab meetings and assist in development and design with current and future in vitro and in vivo work. May be requested to present posters at 1 scientific conference which may require CONUS or OCONUS travel and work to be performed outside normal business hours.
- Participate in mouse, rat, rabbit, or other small animal BSL-2 pharmacokinetics and toxicology studies; to include preparation of antibiotics for administration; administering drugs and vaccines, followed by blood and tissue collection for pharmacokinetic or pharmacodynamic analyses.
- Support the in vivo pharmacology research program and contribute to the multidisciplinary research team to determine pharmacokinetics and pharmacodynamics relationships and efficacy of optimized leads.
- Assist with data analyses and drafting of reports for internal or external customers.
- Work with mass spectrometry, chromatography, HPLC MS/MS, specifically Sciex platforms coupled with Shimadzu HPLCs other and biophysical techniques to support in-process testing and characterization of biopharmaceutical products and impurities.
- Perform bioanalytical data acquisition, data analysis, and reporting of results using Applied Biosystems Analyst, Excel, and the Mass Spec Quantitation Software MultiQuant.
- Complete approximately 25 media/reagent preparations per year.
- Assist with approximately 5 animal challenges per year and 10 bacterial challenge preparations.
- Perform approximately 400 animal injections per year; 400 animal observations per year.
- Support divisional in vivo projects by completing approximately 500 bacterial burdens in animal tissue per year.
- Perform approximately 500 small animal necropsies per year.
- Process approximately 300 animal gavage and approximately 125 animal blood collections per year.
- Place approximately 50 GFEBs orders per year for supplies and equipment.
- Maintain laboratories in BSL-2 and BSL-3.
- Perform or assist with BSAT Inventory Management weekly (to include applicable BSAT working stock material).
- Conduct or assist with Equipment Inventory Management twice a year in BSL-2 and BSL-3.
- Perform or assist with monthly Laboratory Management to include safety functions and chemical inventory.
- Review relevant literature monthly. May assist in the preparation standard operating procedures and manuscripts relating to their research efforts. The Contractor may be expected to present research findings at one scientific conference per year, which may require CONUS or OCONUS travel. Contractor shall present results in written and oral format publicly and internally as requested.
- Maintain a GLP training folder and be compliant with all GLP regulations when applicable.
- Directly contribute to the design, rationale, and be point-of-contact for 10 small animal studies to include drafting of a study plan and oversight of personnel scheduling.
- Contribute to study progress reports and scientific manuscripts to include statistical analysis, data compilation, figure preparation, and methods summary.
- Assist in establishing up to 28 new active material transfer agreements and cooperative research and development agreements with up to 8 pharmaceutical companies and/or universities. Contractor shall maintain records of active agreements and collaborations.
- Other duties as assigned
Qualifications- Bachelor's degree in Biology, Microbiology, Molecular Biology, Biochemistry, Biotechnology, Life Sciences, or a related scientific discipline.
- CS-PRP enrollment is required and shall be held and maintained IAW the provisions in this contract and all applicable regulations.
- BPRP enrollment is required and shall be held and maintained IAW the provisions in this contract and all applicable regulations.
- Typically requires five (5) to seven (7) years of related laboratory experience consistent with a Laboratory Technician 4 labor category.
- Experience performing laboratory procedures, scientific testing, research activities, and technical support functions in bacteriology, microbiology, pharmacology, immunology, molecular biology, or related scientific disciplines.
- Experience independently executing laboratory procedures and scientific protocols with minimal supervision.
- Experience supporting animal studies, laboratory animal procedures, and biological sample collection activities.
- Experience collecting, documenting, analyzing, and reporting scientific and laboratory data.
- Experience supporting laboratory operations, equipment management, inventory control, laboratory safety, and biosafety requirements.
- Experience supporting study planning, laboratory documentation, and scientific reporting activities.
- Ability to work effectively in BSL-2 and BSL-3 laboratory environments.
- Successfully pass required background and drug screening requirements.
- Successfully pass background and drug screening
Preferred Qualifications:
- Experience supporting bacteriology, biodefense, infectious disease, pharmacology, or therapeutic development research programs.
- Experience performing Minimum Inhibitory Concentration (MIC) testing and microbiological susceptibility testing.
- Experience supporting laboratory animal studies, animal challenge models, pharmacokinetic studies, toxicology studies, and necropsy activities.
- Experience administering drugs, vaccines, and biological agents through multiple administration routes.
- Experience supporting mass spectrometry, chromatography, HPLC MS/MS, Sciex platforms, Shimadzu HPLC systems, or related analytical instrumentation.
- Experience performing bioanalytical data acquisition, data analysis, and technical reporting activities.
- Experience supporting GLP-compliant laboratory environments.
- Experience preparing SOPs, scientific reports, technical documentation, manuscripts, and conference presentations.
- Experience supporting laboratory inventories, BSAT management, chemical inventories, and laboratory compliance programs.
- Experience participating in collaborative research efforts involving universities, pharmaceutical companies, or government research organizations.
Knowledge, Skills and Abilities:
- Knowledge of bacteriology, microbiology, pharmacology, laboratory animal science, and biomedical research methodologies.
- Knowledge of in vivo and in vitro research techniques, animal study support activities, and biological sample collection procedures.
- Knowledge of microbiological testing methods, including Minimum Inhibitory Concentration (MIC) testing and bacterial characterization procedures.
- Knowledge of laboratory biosafety practices, laboratory operations, GLP requirements, and applicable regulatory standards.
- Knowledge of mass spectrometry, chromatography, HPLC MS/MS analysis, and bioanalytical testing methodologies.
- Knowledge of data acquisition, statistical analysis, scientific reporting, and technical documentation practices.
- Knowledge of laboratory inventory management, BSAT inventory requirements, equipment management, laboratory safety functions, and chemical inventory controls.
- Ability to independently perform laboratory procedures, scientific testing, animal research support activities, and technical tasks.
- Ability to support study planning, study execution, personnel scheduling, and research coordination activities.
- Ability to analyze, interpret, compile, and communicate scientific and technical data.
- Ability to prepare scientific reports, manuscripts, methods summaries, technical documentation, and presentation materials.
- Ability to maintain laboratory records, study documentation, active agreements, and collaboration records.
- Ability to communicate effectively with investigators, research personnel, laboratory staff, and external collaborators.
- Strong analytical, organizational, problem-solving, written communication, and verbal communication skills.
- Ability to work independently and collaboratively within multidisciplinary research teams.
