The Protein Homeostasis Research Center (TRC) at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The Protein Homeostasis TRC has a major focus of exploiting BMS’ expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable. The group integrates discovery research through translational and early clinical development and exploits state-of-the-art in vitro, in vivo, and ex-vivo models of cancer biology to identify and validate targets and partners closely with colleagues in Translational Development, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.
Position Summary
This role is for a bench-facing research position primarily focused on in-vitro techniques supporting translational biomarker work, indications, and assay development. A keen interest in the emerging biology and therapeutic potential of regulated protein turnover and stability will be helpful.
The qualified candidate will demonstrate the following:
Highly motivated, collaborative, and creative
Ability to work across a highly matrixed environment to develop and implement experiments supporting translational development of novel therapeutics in oncology
Self-starter and team player who can effectively collaborate with colleagues in the protein homeostasis, oncology, protein engineering/antibody development, chemistry, biomarker, and clinical groups.
Proven track record in a relevant scientific area and strong technical skills
Clear and professional verbal and written communication skills, capable of presenting scientific results to multidisciplinary teams and key stakeholders
Experience evaluating and applying technologies in genome, transcriptome, and proteome characterization to preclinical and clinical samples
Key Responsibilities
In the role as a Senior Associate Scientist within Translational Research, the ideal candidate will:
Conduct full time laboratory-based research supporting translational research experiments in the context of preclinical and early-phase clinical trials
Participate on cross-site, cross-functional, and geographically diverse teams.
Work with translational scientists whose activities span cell-based, in vivo, and clinical trial assays, samples, and data.
Work on selection, validation, and deployment of novel clinical-stage assays and analyses of data to accelerate development and provide insight into disease biology and drug mechanisms.
Execute experiments to test hypotheses from clinical observations in preclinical model systems.
Review scientific papers/protocols and apply appropriately to project needs.
Help execute collaborative projects with leading academic and commercial research groups worldwide.
Experience =
Basic Qualifications
Or
Preferred Qualifications
Hands on experience with various in-vitro cellular and biochemical assays, including:
2D/3D cell culture (BSL2+)
in-vitro assays (e.g., co-cultures, transfections, shRNA, CRISPR technology, CTG, IncuCyte, and other cell-based assays)
in-vivo sample processing (xenografts and other specimens)
RNA analyses (e.g., qPCR, Nanostring)
protein analyses (e.g., Westerns, MSD, ELISAs, Flow Cytometry, IP, HCS, IHC, fluorescent microscopy)
Familiarity with next-generation sequencing technologies, including RNA-seq, whole exome/genome sequencing, ChIP-seq
Aptitude in experimental design, execution, data analysis and troubleshooting. In touch with new technology, assays, automation, and innovative in approaches to complex problems.
Data mining proficiency with public and internal databases (e.g., UCSC genome browser, DepMap, cBIO).
Proficiency in utilizing software such as Graph Pad, E-notebook, Microsoft office, FlowJo, etc. for data analyses and figure generation.
Attention to detail with excellent organizational and record keeping skills.
Excellent interpersonal skills with the ability to interact effectively with diverse types of people, internally and externally.
Familiarity with the drug development process, translational work, and knowledge of assay design, creation, and validation.
Ability to stay focused, with attention to details, and to deliver high quality data in a timely and well-organized manner.
Ability to handle multiple projects and work in a fast-paced dynamic team environment.
Initiative, responsibility, and flexibility to adapt to changes with a positive attitude.
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If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Brisbane - CA - US: $107,240 - $129,945
The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.
Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:
Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include:
Paid Time Off
US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.
