Senior Associate Scientist (EG90 Lvl2), LNP Process DevelopmentIn October 2025, BMS significantly expanded its RNA medicines capabilities through the acquisition of Orbital Therapeutics, bringing with it a powerful and differentiated RNA platform that combines circular and linear RNA engineering, advanced delivery technologies, and AI-driven design. This platform is accelerating BMS's efforts to pioneer a new generation of programmable RNA therapies across immunomodulation for autoimmune disease and oncology, next-generation vaccines, and protein therapeutics.
As we continue to grow and integrate this delivery platform, we are building out a world-class LNP Process Development team based in Cambridge, MA. If you are passionate about cutting-edge RNA delivery science and want to contribute to medicines that have the potential to transform patient lives in ways not previously possible, we invite you to join us.
Position SummaryBristol Myers Squibb is seeking a motivated and detail-oriented Senior Associate Scientist to join our LNP Process Development team in Cambridge, MA. The LNP PD team works to develop, characterize, and implement robust preclinical and clinical manufacturing processes to support Bristol Myers Squibb's exciting pipeline of products. This role is specifically focused on LNP process development, with responsibilities spanning early process development through clinical manufacturing support.
This is an excellent opportunity for an early-career scientist to grow within a dynamic, fast-paced environment. The successful candidate will support planning and execution of laboratory studies and contribute to protocols, technical reports, and regulatory documentation under the guidance of senior team members.
Responsibilities: - Execute hands-on laboratory experiments focused on LNP process development and scale-up from bench to pilot scale
- Design and perform experiments for optimization and characterization of targeted lipid nanoparticles using structured approaches in both upstream and downstream unit operations(i.e. QbD principles, DoE)
- Contribute to the authoring and review of technical protocols, experimental reports, and batch records in support of early- to late-stage development activities
- Perform routine analytical testing to assess LNP conjugation, particle size, encapsulation and concentration
- Analyze and interpret experimental results, present findings to senior scientists and project teams
- Collaborate with internal R&D, analytical development, and manufacturing to advance BMS's LNP pipeline
- Support interactions with manufacturing partners, including review of technical documents and participation in technology transfer activities as needed
- Maintain accurate and complete laboratory notebooks and documentation in compliance with internal quality standards
Qualifications: - BS with 2+ years of industry experience, or MS with 0-3+ years of relevant experience, in Chemical Engineering, Biomedical Engineering, Biochemistry, or a related scientific discipline
- Hands-on experience with LNP formation techniques both at small scale and at large scale
- Familiarity with analytical tools used to assess LNP quality, including ribogreen for measuring encapsulation efficiency, and DLS for measuring particle size
- Basic understanding of LNP formation unit operations
- Strong laboratory fundamentals and attention to detail; comfortable working with bench-top equipment including nanoparticle formation equipment and UF/DF skids
- Ability to organize and analyze experimental data, identify trends, and clearly communicate results to team members
- Exposure to GMP principles or cGMP environments is a plus but not required
- Experience with design of experiments (DoE) or statistical analysis software is a plus
- Ability to travel to internationally up to 10% of the time
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Compensation Overview:Cambridge - MA - US: $96,010 - $116,339
The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.
Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:
- Health Coverage: Medical, pharmacy, dental, and vision care.
- Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
- Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include:Paid Time Off
- US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
- Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.
