JOB SUMMARY

We are seeking a highly motivated and innovative scientist to drive advances at the interface of RNA biology, computational modeling, and machine learning. In this role, you will design and implement cutting-edge computational approaches to uncover RNA structure–function relationships and to support discovery and development programs across the organization. You will work with complex datasets and build computational tools that provide high-throughput, data-driven insights to accelerate next-generation mRNA medicines.

The ideal candidate has a strong foundation in RNA biology, is proficient with RNA secondary structure analysis tools, and has hands-on programming experience in languages such as Python or R. You will work extensively in cloud-based, high-performance computing environments and apply modern software engineering practices to deliver robust, scalable, and well-documented computational solutions.

This is a highly collaborative role, requiring close partnership with both wet-lab and dry-lab teams. You will manage multiple dynamic projects, help shape scientific strategy, and clearly communicate findings to diverse stakeholders. A strong track record of impactful research—demonstrated by publications or patent contributions—is strongly preferred. If you excel in a fast-paced, interdisciplinary environment and are excited to push the boundaries of computational RNA science, we would love to hear from you.

RESPONSIBILITIES

• Build and implement custom mRNA optimization strategies to fine tune expression, stability, and immunogenicity, and function of the RNA payload.
• Innovate on mRNA designs by utilizing scientific literature to implement novel design principles.
• Collaborate within the RNA sciences team to generate and analyze NGS data from RNA structure probing and other RNA biology-directed experiments such as SHAPE-MaP, DMS-MaP, ribosome profiling, RIP-seq etc.
• Lead crossfunctional collaboration with experimental biologists, molecular biologists, and therapeutic project teams to design studies, set experimental priorities, and validate computational discoveries.

Basic Qualifications

• Bachelor's Degree 5+ years of academic / industry experience
• Or Master's Degree 3+ years of academic / industry experience
• Or PhD No experience required

Preferred Qualifications

• Ph.D. +1 years in Computational Biology, Physics, Computer Sciences or related field.
• Experience with diverse RNA sequencing modalities beyond standard RNA-seq (e.g., ribosome profiling, CLIP-seq, single-cell RNA-seq, SHAPE-seq, spatial transcriptomics)
• Experience in applying AI/ML models to NGS datasets to elucidate RNA biology
• Utilization of computational modeling to evaluate nucleic acid functions required
• Ability to dissect RNA secondary structure prediction concepts and computational tools highly preferred
• Experience with one or more programming or scripting languages such as Python and R
• Experience with cloud computing platforms and high-performance computing environments

All eligible employees receive a competitive package that includes: compensation, discretionary bonus, Incentive Stock Options, the opportunity to participate in the Companys 401k plan, health, dental, and vision benefits, life and disability insurance benefits, voluntary benefits, non-accrual paid time off, company shut down for holidays, and free parking and the opportunity to work in a state of the art building at Cambridge!

Compensation Overview:

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employees work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical, pharmacy, dental, and vision care.

• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).

• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

0Work-life benefits include:

Paid Time Off

• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)

• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.