Job Function: Discovery & Pre-Clinical/Clinical Development
Job Sub Function: Biological Research
Job Category:Scientific/Technology
All Job Posting Locations:Spring House, Pennsylvania, United States of America
Job Description:An internal pre-identified candidate for consideration has been identified. However, all applications will be considered.
We are searching for the best talent for a
Scientist II Interventional Oncology to join our Discovery Biology team based in
Spring House, PA.
The successful candidate will join a dynamic, multidisciplinary team of scientists in exploratory immuno-oncology, playing a key role in the evaluation and understanding of new drug concepts in vivo and in vitro.
Responsibilities:- Execute in vivo pharmacology experiments end-to-end, including tumor cell culture, tumor cell implantation, dosing, and handling of investigational drugs (including chemotherapeutics), tumor volume measurements, and collection of tissues/tumors for downstream analysis
- Monitor ongoing in vivo experiments on a daily basis and collaborate closely with other scientists and SIS staff/Veterinary teams (VETs) to ensure animal welfare and health monitoring
- Assist the team with the planning, design, and execution of various in vivo syngeneic and xenograft studies, utilizing established DDI guidelines for in vivo data collection, analysis, and reporting
- Conduct in vitro human and ex vivo mouse immunology experiments, as required, to support the ongoing INTO portfolio or pre-portfolio programs, including assays using cancer cell, myeloid, and T-cell-based co-cultures
- Demonstrate agility and learning flexibility in applying diverse cellular and molecular biology techniques, including cell/organoid assays, FACS, ELISA, MSD, and qRT-PCR
- Support the Discovery Biology team with experimental setup, assay optimization, and data analysis using appropriate statistical methods, and prepare data in presentation-ready formats and for Electronic Lab Notebook (ELN) entry; provide updates in team and discovery meetings
- Maintain detailed experimental records and ensure compliance with all relevant internal and external training requirements
- Work as a team player and support day-to-day activities, including ordering laboratory reagents and supplies, as needed
Qualifications/ExperienceRequired:- A minimum of a Bachelor's degree in Life Sciences (e.g., Biology, Biochemistry, Pharmacology, or Tumor Immunology) with 3 to 5 years of relevant laboratory-based experience in industry, biotech, or an academic setting; alternatively, a Master's degree (M.S.) with relevant pharmaceutical, biotech, laboratory, or academic experience
- Experience with animal handling in oncology-relevant rodent models, including subcutaneous and orthotopic tumor implantation techniques, dosing, proper handling of therapeutics, tumor measurements, health monitoring, and data collection and analysis
- Experience adhering to animal welfare and compliance regulations
- Experience with drug administration via subcutaneous, intraperitoneal, and intravenous tail vein injections, as well as oral gavage
- Experience with blood collection techniques, including tail vein, saphenous vein, and cardiac puncture
- Experience performing animal autopsy/dissection, microsurgery, perfusion, and tissue collection
- Familiarity with animal use protocols (AUP) and global IACUC policies
Preferred:- Experience with cell culture of cancer or immune cells
- Experience with bioluminescent imaging, flow cytometry, immunohistochemistry (IHC), and ELISA/MSD
- Strong learning agility and the ability to work across multiple projects
Additional Information:- This position may require occasional weekend, evening, and holiday dosing and/or animal monitoring
- This is not an exhaustive list of job functions; additional responsibilities may be assigned as needed for various projects
Other Requirements- Excellent interpersonal skills with the ability to work effectively in a matrixed team environment
- Strong organizational, data management, and record-keeping skills
- Excellent verbal and written communication skills in English
- Employment is contingent upon completion of required laboratory and animal research training courses and maintaining compliance thereafter
- Proficiency in Microsoft Office and GraphPad Prism
#LI-Onsite
Required Skills: Preferred Skills:Analytical Reasoning, Biological Sciences, Communication, Data Analysis, Data Compilation, Data Savvy, Design of Experiments (DOE), Drug Discovery Development, Execution Focus, Laboratory Experiments, Molecular Diagnostics, Pharmaceutical Microbiology, Product Knowledge, Project Management, Report Writing, Scientific Research, Technologically Savvy, Troubleshooting
