What You Will AchieveThis position will be part of Drug Product Design and Development (DPDD) within the Pharmaceutical Research and Development (PhRD) department. The incumbent will participate in the development of parenteral formulation for biologics modalities such as monoclonal antibodies, peptide-based therapeutics, antibody drug conjugates, proteins, and vaccines. This position will be responsible for performing formulation development and analytical characterization of candidate molecules by using various biophysical and biochemical characterization techniques. Furthermore, this position will assist in developing processes for drug product manufacturing, responsible for data compilation, data presentations and report writing.
Your strong foundation in general scientific practice, its principles and concepts will help in meeting critical deadlines. You will be relied on as a technical contributor to assess the assigned tasks and make decisions that involve direct application of your knowledge.
It is your dedication that will make Pfizer ready to achieve new milestones and help patients across the globe.
How You Will Achieve ItThe responsibilities of the Scientist position include but are not limited to:
- Participate in developing parenteral formulations for biotherapeutic modalities such as monoclonal antibodies, peptide-based therapeutics, antibody drug conjugates, proteins and vaccines. This position will be responsible in developing manufacturing processes (under general supervision).
- Perform rapid, comprehensive characterization of candidate molecules to determine the stability profile and applying this information to develop an appropriate dosage form to meet clinical needs. This will be achieved by applying various biophysical and biochemical techniques such as UPLC (SE-UPLC, IEX, RP-UPLC), SDS-PAGE, LC-MS, Capillary Gel electrophoresis (CGE), imaged Capillary Electrophoresis (iCE), Spectroscopy techniques such as UV and Fluorescence spectroscopy, Circular Dichroism and FTIR.
- The incumbent will develop and scale-up drug product processes from bench top to pilot scale and, as required, assist in technology transfer to commercial plants. Examples of drug product processes are fluid transport, sterilizing filtration and lyophilization.
- The Scientist must be able to interact effectively with a multi-disciplinary team of scientists for formulation optimization and overall candidate progression.
- This position will be responsible for preparing data summary presentation, compiling data and authoring technical reports.
- Effective communication skills are desirable for interactions with laboratory scientists, project managers and colleagues from numerous functions, serving on multi-disciplinary project teams.
Qualifications- B.S. in Biochemistry, Chemical/Biochemical Engineering, Pharmacy, Chemistry, Biology, or equivalent with a minimum of 6 years' relevant industry experience, OR MS in Pharmaceutics, Biochemistry, Chemical/Biochemical Engineering, Chemistry, Biology, or equivalent with a minimum of 4 years' relevant industry experience
- Ability to follow established procedures independently is required.
- Proven competency in conducting analysis of biologics using SE-UPLC, RP-UPLC, LC-MS, peptide mapping, UPLC (IEX), SDS-PAGE, Capillary Gel electrophoresis (CGE), imaged Capillary Electrophoresis (iCE), spectroscopy techniques.
- Demonstrated scientific documentation skills
Preferred Qualifications- Experience with drug development of biologics and vaccines.
- 5+ years of hands-on lab experience in analytical techniques.
- Excellent documentation skills.
- Self-motivated and highly effective in a team-based environment.
- Effective written and oral communication skills.
- Familiarity with GMP requirements.
- Familiarity with parenteral manufacturing requirements, container/closure integrity, and clinical and commercial unit operations.
- Practical knowledge of lyophilization and lyophilization cycle development
PHYSICAL/MENTAL REQUIREMENTSThis is a lab-based position and incumbent must be able to work in a lab, in a LAP hood, BSC, etc.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Occasional travel to other Pfizer sites or, CMO/CDMO, or training/conference may be needed.
Work Location Assignment: On Premise
The annual base salary for this position ranges from $79,400.00 to $132,400.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
