AbbVie

Scientist II, Biologics Drug Product Development

AbbVie • $110K — $130K *
South San Francisco, CA 94080In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
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Job Overview by Ladders

Qualifications

  • Bachelor's or Master's in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field with required industry experience.
  • Hands-on experience in biologics drug product development and formulation.
  • Deep expertise in HPLC/UPLC methodologies and troubleshooting methods.
  • Experience with analytical techniques for protein characterization and stability testing.
  • Strong data analysis skills, especially with chromatography data systems.

Responsibilities

  • Lead and execute drug product development studies for clinical support.
  • Generate scientific data for regulatory submissions and documentation.
  • Collaborate with cross-functional teams to advance drug development programs.
  • Conduct hands-on experiments to enhance understanding of formulation attributes.
  • Improve formulation strategies and drug product processes through innovation.
  • Serve as the HPLC/UPLC technical resource and maintain equipment.
  • Analyze and document experimental data clearly and present findings confidently.

Benefits

  • Paid time off including vacation, holidays, and sick leave.
  • Medical, dental, and vision insurance coverage.
  • 401(k) plan to support retirement savings.
  • Participation in short-term incentive programs.
Full Job Description
Job Description

The Drug Product Development group within AbbVie is a global organization responsible for developing and characterizing drug product formulations and manufacturing processes for biologic therapeutics (antibodies, multispecitics, antibody-drug conjugates (ADCs), neurotoxins, and novel biologic formats) from preclinical development through clinical proof of concept.

We have an exciting opportunity for a Scientist I/II to join our team at our Bay Area site in South San Francisco, CA. This role is an onsite role in a lab-based function and will focus on driving drug product development through formulation, process and in-use and will be the HPLC/UPLC technical lead and subject matter expert. This position is ideal for a scientist with experience in biologics formulation and characterization who is passionate about chromatography and eager to support the team as to ensure utility and maintenance of HPLC/UPLC instruments. To be successful, candidates must thrive in a highly collaborative laboratory environment with daily face-to-face interactions across multiple scientific disciplines.

KEY RESPONSIBILITIES INCLUDE:

Formulation & Biologics Drug Product Development
  • Independently lead and execute drug product development studies to support clinical studies, including formulation screening, in-use studies, and manufacturing process support.
  • Generate robust scientific data and documentation to support IND/NDA/BLA regulatory submissions, CTD module documentation, and technical reports.
  • Collaborate with cross-functional partners including Analytical Development and Drug Substance team to advance pipeline programs.
  • Develop scientific understanding of formulation attributes and product quality characteristics through hands-on laboratory experimentation and data interpretation.
  • Contribute to continuous improvement of formulation strategies and drug product processes, applying scientific rigor and innovation.

HPLC/UPLC Subject Matter Expertise
  • Serve as the primary technical resource and owner for HPLC/UPLC systems within the Drug Product Development group and implement a system to keep HPLC/UPLC instruments maintained, operational, and minimize downtime.
  • Lead troubleshooting and root-cause investigations for chromatographic instrumentation, methods, and data acquisition systems to maximize instrument uptime and laboratory productivity.
  • Coordinate instrument maintenance, qualification activities, and vendor support while ensuring compliance with laboratory procedures and quality requirements.
  • Act as an Empower software superuser by supporting users, troubleshooting data acquisition and processing issues, and promoting efficient data management practices using AbbVie data strategy tools.
  • Develop and deliver HPLC training curricula, maintain SOPs and training materials, and serve as a technical resource and scientific consultant on HPLC-related matters.
  • May provide guidance for HPLC/UPLC method adjustments to enable accelerated characterization of new molecules.

Scientific Contribution & Communication
  • Independently analyze, interpret, and document experimental data in electronic lab notebooks (ELN) with clarity and completeness.
  • Present scientific findings to project teams, management, and cross-functional stakeholders with confidence and scientific rigor.
  • Author technical reports, SOPs and development summaries and contribute to regulatory documents, scientific publications, and patent applications as needed.
  • Stay current with emerging trends and innovations in formulation science, analytical chemistry, and HPLC/UPLC technology; proactively apply learnings to internal programs.


Qualifications

Education
  • Bachelor's degree in Pharmaceutical Sciences, Chemistry, Biochemistry, Chemical Engineering, or a related discipline with typically 4-5 years (Scientist I) or 7+ years (Scientist II) of relevant industry experience
  • Master's degree in a related discipline with typically 2 years (Scientist I) or 5+ years (Scientist II) of relevant industry experience

Required Experience & Skills
  • Demonstrated hands-on experience in biologics drug product development, including formulation development, characterization, and stability assessment.
  • Strong practical understanding of protein degradation pathways and analytical characterization approaches used to assess biologic product quality.
  • Broad and deep hands-on expertise with HPLC/UPLC across multiple modalities (e.g. RP, SEC, IEC, HIC, etc.) with a proven track record as an SME, including method development and troubleshooting capabilities
  • Hands-on experience with analytical techniques used for protein characterization and stability testing (e.g., SEC, RP-HPLC, CE-SDS, icIEF, HIAC, MFI, DLS, SoloVPE or equivalent).
  • Experience with in-use stability and/or clinical compatibility studies for biologic drug products preferred.
  • Proficiency in scientific data analysis and statistical tools, especially chromatography data systems (e.g. Empower).
  • Strong oral and written communication skills, with experience authoring reports, standard operating procedures (SOPs), and regulatory documents.
  • Ability to independently manage multiple projects with competing priorities.
  • Preferred Experience
  • Experience with DoE (Design of Experiments) for formulation and process optimization.
  • Prior experience supporting IND, NDA, or BLA filings.
  • Experience contributing to scientific publications or patent applications.
  • Experience in automation and data digitalization.


Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
  • This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

About AbbVie

AbbVie develops pharmaceuticals and medical devices. They provide products and services to therapeutic areas including immunology, oncology, neuroscience, eye care, virology, women's health, and gastroenterology.

AbbVie Careers

Joining AbbVie means becoming part of a global team dedicated to making a remarkable impact on patients' lives. At AbbVie, our employees are united in the pursuit of groundbreaking innovation and are committed to transforming the future of healthcare with leading-edge science.

Work You’ll Do

At AbbVie, you’ll collaborate with some of the brightest minds in the industry to solve challenging problems that have a high impact on society. Our culture fosters growth and embraces leadership and diversity training, ensuring that every team member can thrive.

Explore Job Opportunities

AbbVie offers a wide range of job opportunities and career paths, providing a platform where professionals can propel their careers forward. From research and development to marketing and sales, the potential to make a significant impact is limitless.

Internship Programs

Kickstart your career with an AbbVie internship. Our programs provide invaluable industry experience and a chance to develop essential skills in a real-world setting. Interns at AbbVie are considered integral members of the team and are given tasks that are both challenging and rewarding.

Professional Growth and Development

We believe in nurturing our team's professional growth through comprehensive training programs, leadership development opportunities, and continuous learning. Our commitment to your career growth is reflected in our robust offerings that enhance your skills and knowledge.

Benefits and Culture

AbbVie is dedicated to supporting our employees' well-being both inside and outside of work. Our benefits package includes health, financial, and social benefits that are designed to support the diverse needs of our employees. Our inclusive culture encourages collaboration and innovation, fostering a workplace where all can excel.

Hiring Process

Our hiring process is designed to ensure a match that will be beneficial both for the company and for your career aspirations. From resume submission to interview, each step is an opportunity to showcase your skills and fit with the AbbVie team.

Networking and Career Advancement

At AbbVie, networking doesn’t just enhance your career; it propels it. We encourage our employees to engage internally and externally to build relationships that foster personal and professional growth.

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Explore AbbVie Jobs

Whether you’re seeking to advance your career in a dynamic and empowering environment, or looking for a place where you can innovate, lead, and contribute to something bigger, AbbVie is the place for you. Join us in our mission to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow.
Learn more about AbbVie
Size
50,000 employees
Market Cap
$288.5 billion
Industry
Pharmaceuticals & Biotech
Net Income
$4.6 billion
Founded
2013
5 Year Trend
+17%
Revenue
$45.8 billion
NASDAQ
ABBV
* Ladders Estimates

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