SummaryThe Scientist I, Radiochemistry - Isotope Production will be responsible for taking a lead technical role in both R&D radiochemical and analytical methods supporting various isotope programs at RayzeBio. The Scientist's role will be to support the development, optimization, and scale-up of radiochemical processes to produce Actinium-225 through cyclotron irradiation of Radium-226 targets. This role will focus on radiochemical separations, process engineering, automation, and manufacturing readiness associated with alpha-emitting isotopes. This individual will play a key role in translating laboratory-scale concepts into robust, scalable production processes suitable for implementation in shielded hot cells and GMP manufacturing facilities. Additional responsibilities may be assigned as required to bring technical expertise to RayzeBio initiatives.
Job ResponsibilitiesEssential duties and responsibilities include the following. Other duties may be assigned.
- Design, execute, and optimize radiochemical processes associated with the production, purification, and recovery of Actinium-225 and related isotopes.
- Develop and implement separation and purification methods using chromatography, precipitation, solvent extraction, and other radiochemical techniques.
- Support process scale-up from benchtop experiments to shielded hot cell operations.
- Perform hands-on work with radioactive materials, including alpha-emitting isotopes, while maintaining strict adherence to radiological safety practices.
- Develop process flow diagrams, equipment specifications, operating procedures, and technical reports.
- Collaborate with engineering teams on process equipment design, automation systems, shielding requirements, and facility integration.
- Participate in target processing development, radionuclide recovery strategies, waste minimization efforts, and process troubleshooting.
- Evaluate emerging technologies and scientific literature to improve isotope production efficiency, reliability, and throughput.
- Generate and analyze experimental data using statistical and scientific methods to guide process decisions.
- Support technology transfer activities into manufacturing environments.
- Uses AI tools to enhance individual productivity and quality of work
- Contribute to regulatory documentation, safety reviews, and manufacturing readiness assessments as needed.
- Mentor junior scientists and technicians while promoting a culture of scientific rigor and operational excellence.
- Less than 5% of travel is required
Education and Experience- BS/MS with 5+ years of experience, and/or 3+ years of hands-on experience in Radiochemistry or other scientific equivalent working with open-source radioactive materials.
- PhD with 1+ years of experience in Radiochemistry or other scientific equivalent work experience.
Skills and Qualifications- Direct experience with Actinium-225, Radium-226, Thorium-229, Thorium-228, Radium-224, or other alpha-emitting isotope systems.
- Experience with hot cells, gloveboxes, shielded enclosures, and remote handling systems.
- Familiarity with cyclotron-produced radioisotopes and post-irradiation target processing.
- Experience with ion exchange chromatography, extraction chromatography, solvent extraction, and radionuclide recovery methods.
- Experience with process automation, fluid handling systems, or automated separation equipment.
- Proficiency with analytical instrumentation such as HPGe spectroscopy, alpha spectroscopy, ICP-OES, ICP-MS, liquid scintillation counting, or related techniques.
- Familiarity operating in a GxP setting.
- Excellent scientific data analysis and technical writing skills.
- Excellent professional ethics, integrity, and ability to maintain confidential information.
Physical DemandsWhile performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 30 pounds. Specific vision abilities required by this job include close vision and distance vision.
This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials.
Work EnvironmentThe noise level in the work environment is usually moderate.
Compensation Overview:Indianapolis - RayzeBio - IN: $96,148 - $116,508
The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.
Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:
- Health Coverage: Medical, pharmacy, dental, and vision care.
- Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
- Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include:Paid Time Off
- US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
- Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.
RayzeBio and Bristol Myers SquibbRayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however, RayzeBio will continue to operate as a standalone organization.
