Job Summary:
The successful candidate will have extensive hands-on experience with standard cell biology, molecular and immunological techniques (qPCR, cloning, CRISPR Knock-out/knock-in, western blots, primary cell, immune cell and cell line-based assays, flow cytometry, ELISA, Immunocytochemistry (ICC)). This position will be responsible for executing towards the validation of multiple novel drug targets via a variety of mechanisms, including generating appropriate knockout and knock-in in cells, testing the effects of tool compounds on proteins in cellular and biochemical settings, and the use of Vividion's proprietary chemical proteomics platform.
Requirements
Education and Experience requirements:
- BS/MS with 10+ years OR PhD with 0-2 years' experience in molecular biology, cellular biology, immunology or a related field
- Expertise in use of various biology techniques including qPCR, CRISPR (Knock-out and knock-in), siRNA or shRNA transfection, Western blot, ELISA, AlphaLISA and MSD assay
- Experience in validating and executing cellular assays using primary cells or cell lines to test the activity of compounds
- Experience in assay development for compound screening and mechanism of action studies
- Proficiency in T cell assays and Immunocytochemistry (ICC) is preferred
- Ability and independency to research literature and present ideas/data to support target validation or compound testing
Pay & Benefits:
The anticipated annual base salary for this position ranges from $115,000 to $125,000 depending on relevant skills, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance.
