*Note: exact level depending on experience*
Job Summary:
The successful candidate will have extensive hands-on experience and expertise in the evaluation of the impact of small molecules on protein function and stability both in vitro and in a cellular context via cell and/or biochemical assay development. This position will be responsible for leading/supporting efforts towards the validation of novel drug targets via multiple mechanisms, including testing the effects of tool compounds on proteins in cellular and biochemical settings, and the use of Vividion's proprietary chemical proteomics platform.
Requirements
Education and Experience requirements:
- PhD and post-doc experience in biochemistry, chemical biology, cell biology or related disciplines
- 5+ years of post-graduate industry experience in chemistry, chemical biology or pharmaceutical chemistry
- Required technical skills include a strong molecular biology skill set (e.g., DNA cloning, site-directed mutagenesis, CRISPR, transient transfection, viral transduction, gene expression analysis), Protein expression analysis (western blot/ ELISA/ProteinSimple), mammalian cell culture, microscopy, and functional/phenotypic assays (Cell Viability 2D and 3D, Soft agar, Apoptosis)
- Experience in mass spectrometry-based analyses for chemical proteomics investigations along with chemical principles and structure-activity relationships
- Deep understanding of protein/ligand interactions, how to measure them, and how to characterize downstream functional effects arising from those interactions
Required Key Attributes:
- Candidates must have strong communication skills as evidenced in public presentations and/or peer reviewed literature.
- Candidates must have effective troubleshooting and problem-solving skills.
- Candidates must be an effective team player, strong individual contributor, flexible, and able to handle multiple tasks and deliver high quality results under tight timelines.
Pay & Benefits:
The anticipated base salary for this position ranges from $120,000 to $155,000 depending on relevant skills, competencies, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance.
