Job DescriptionBiologics Drug Product Development (Bio DPD), a part of Development Sciences within AbbVie's R&D, is a global organization that is responsible for drug product formulation and process development, and definition of the product presentation for biologics (proteins, conjugates, peptides, etc.) and genetic medicine (AAV, LNPs, Cell Therapy).
AbbVie is seeking a highly motivated candidate for the position of Scientist I/II, Biologics Drug Product Development, located in North Chicago, IL. We are seeking a scientist with experience in Biologics Formulation and Drug Product Development. Ideally someone who can do the following:
- Apply engineering principles to develop, characterize, scale, and transfer robust drug product processes.
- Independently execute laboratory experiments to address critical project needs and identify opportunities for development and improvement in collaboration with supervisor.
- Continuously seek to improve existing laboratory methods and processes.
- Demonstrate mastery of experimental techniques and methods of data analysis used in day-to-day responsibilities.
- Collaborate effectively with cross-functional groups to support project goals
Responsibilities- Independently design, execute and interpret critical experiments to answer scientific questions. Understand the broad objectives of the project as well as their role in achieving those objectives, and modify experimental plan when required, to respond.
- Support development projects with hands-on laboratory experimentation, data generation, and analysis of results. As needed, provide support for technical transfer and scale-up of laboratory process knowledge to manufacturing sites.
- Learn, understand and master new experimental techniques and develop proficiency in techniques, and act as a resource or mentor for others.
- Innovate and implement new experimental protocols.
- Demonstrate a high level of proficiency in his/her field.
- Set and meet experimental and project timelines in accordance with CMC strategy.
- Effectively organize and present scientific plans and data. Maintain detailed and organized electronic laboratory notebook, and compile data into scientific presentations and reports to support project goals.
- Contribute to writing and conceptual framework of publications, presentations, and patents.
- Routinely read and apply relevant scientific literature. Impact projects mostly through lab and/or pilot plant based activities where applicable.
Qualifications- Scientist II, required: BS or equivalent education with 7 or more years of experience or MS or equivalent education with 5 or more years of experience.
- Scientist I, required: BS or equivalent education with 5 or more years of experience or MS or equivalent education with 3 or more years of experience.
- Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions.
- Demonstrated ability to learn, understand and master new experimental techniques.
- Ability to multitask and work within timelines.
- Demonstrated scientific writing skills and strong verbal communication skills.
Preferred Qualifications:- Experience with biologics (proteins, conjugates and/or peptides) formulation development, in-use studies, and DP process development.
- Experience with sterile manufacturing unit operations (freeze-thaw, mixing, filtration, filling, and freeze-drying) development and characterization
- Experience with scale-down models, simulation, scale-up, and technology transfer.
- Hands-on experience with biologics drug product manufacturing, preparation and analysis, e.g. HPLC/UPLC, UV-Vis spectroscopy, CE-SDS, icIEF, HIAC, MFI, DLS, DSC, etc.
- Knowledge of Design of Experiment (DoE), data analysis and experience of statistical software packages is preferred.
- Understanding of relevant cGMP and regulatory guidance.
- Ability to multitask and meet timelines in a dynamic environment.
Additional InformationApplicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
- The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.
