Crown Bioscience

Scientist I

Crown Bioscience • $84K — $115K *
Louisville, CO 80027In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
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Job Overview by Ladders

Qualifications

  • Ph.D. in Biochemistry, Analytical Chemistry, or related field with 0-3 years experience; M.S. with 3-7 years; B.S. with >7 years.
  • Strong understanding of protein structures, stability, and PTM degradation pathways.
  • Proficiency in scientific software and data analysis tools, like Excel and Prism.
  • Excellent communication skills for presenting complex data.
  • Ability to work both independently and as part of a team in a fast-paced environment.
  • Adaptable to changing priorities and business needs.

Responsibilities

  • Demonstrate expertise in executing and interpreting experiments that support project goals.
  • Utilize mass spectrometry techniques for protein analysis, including intact mass and peptide mapping.
  • Optimize chromatographic modalities like SEC, RP, HILIC, and CEX relevant to mass spectrometry.
  • Design and execute analytical experiments for biotherapeutics development, ensuring validation and stability studies.
  • Generate documentation suitable for publication and regulatory review, including analytical test methods.
  • Serve as a subject matter expert for client programs, offering technical guidance and representation.
  • Mentor and train junior scientists while performing peer reviews of development and stability reports.

Benefits

  • Collaborative work environment with cross-functional teams.
  • Opportunities for mentoring and professional development.
  • Engagement with client programs, enhancing networking and visibility in the field.
  • Involvement in innovative biotherapeutics projects from early development to commercialization.
Full Job Description
KBI Biopharma is seeking a highly skilled and motivated Analytical Scientist to join our Analytical and Formulation Sciences (AFS) team in Louisville, CO. This role is ideal for a scientist with deep expertise in protein analytics, ideally with a background in mass spectrometry and protein structural characterization. You will serve as a subject matter expert (SME), driving innovation and excellence in analytical testing to support client programs from early development through late-phase and commercialization for biotherapeutics.

Position Responsibilities:

  • Demonstrates expertise in the execution and interpretation of experiments that contribute to project goals.
  • Expertise in mass spectrometry techniques including intact mass and subunit analysis, reduced and non-reduced peptide mapping, and PTM and sequence variant analysis.
  • Significant experience is desired in optimizing multiple chromatographic modalities relevant to mass spectrometry, including SEC, RP, HILIC, and CEX.
  • Familiarity with Agilent, Waters, and Thermo LC-MS systems.
  • Occasional recourse to non LC-MS methods including capillary electrophoresis (SDS-CGE and icIEF), UV/Fluorescence, compendial methods, and biophysical characterization techniques on proteins (CD, FTIR, DLS, SEC-MALS, calorimetry).
  • Design and strategically execute analytical experiments in support of biotherapeutics development, particularly qualification/validation and stability studies.
  • Generate high-quality documentation suitable for publication and regulatory review, including technical documents and analytical test methods.
  • Act as SME on client programs, providing technical guidance and representing KBI in client interactions.
  • Collaborate cross-functionally with rapid analytics, process development, bioassay, and program management teams.
  • Mentor and train junior scientists and associates.
  • Perform peer review of data and reports related to method development, qualification, and validation, as well as characterization and stability study reports.
  • Manage timelines and resources to meet project milestones and proactively advise leadership on program status and technical challenges.

Minimum Requirements:
  • Ph.D. in Biochemistry, Analytical Chemistry, or a related field with 0-3 years experience; M.S. with 3-7 years experience; B.S. degree with >7 years experience.
  • Adaptability to changing priorities and business needs.
  • Adherence to statutory and company safety requirements.
  • Strong understanding of protein structure and stability and degradation pathways leading to PTMs.
  • Excellent communication skills and ability to present complex data to diverse audiences.
  • Proficiency in scientific software and data analysis tools (e.g. Excel, Prism).
  • Ability to work independently and collaboratively in a fast-paced environment.


Salary: $84,000-$115,000

About Crown Bioscience

Crown Bioscience is a global drug discovery and development services company that specializes in preclinical research. The company was founded in 2006 and is headquartered in Shanghai, China. Crown Bioscience provides a range of services to pharmaceutical and biotechnology companies, including in vitro and in vivo testing, translational oncology, and more. The company has facilities in China, the United States, and Europe. Crown Bioscience is committed to advancing drug discovery and development through innovative research and technology.
Learn more about Crown Bioscience
Size
1,000 employees
Industry
Pharmaceuticals & Biotech
Founded
2006
* Ladders Estimates

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