Overview:
Business Title:
Scientist IPosition Title:
Scientist IDivision:
Consumer Products ServicesEntity:
Consumer Products Services/ATLLocation:
Indianapolis, INReports to:
ManagerFLSA:
Non-exemptHours Worked:Typically,
Monday through Friday, forty-hours per week. However, must be flexible to meet the needs of the department and complete other projects as assigned.
Position Summary:
The
Scientist will be responsible for performing oligonucleotides development work and supporting analytical characterization using various instruments including but not limited to LC-UV/LC-MS.
Duties and Responsibilities:
It is everyone's responsibility to live out our Values and Absolutes by Shaping a World of Trust while ensuring responsible progress.- Design and execute experiments related to sample preparation, quality control method development, and method condition screening, ensuring methods are scientifically sound, reproducible, and aligned with project or client objectives.
- Develop, adapt, and improve laboratory protocols, including but not limited to sample preparation, mobile phase preparation, sample quality control, chemical stability, and accelerated stability evaluation, to support consistent and reliable qualification and quantitation of target analytes.
- Perform complex mobile phase and sample preparations in support of analytical method development and non-routine laboratory activities.
- Execute laboratory SOPs to perform oligonucleotide formulation by using common laboratory equipment and techniques including but not limited to balance, centrifuge, pH meter, titration, vacuum filtration, and vial filling.
- Troubleshoot and perform basic preventive maintenance on analytical instrumentation including Agilent Bio-UPLC, and SQ systems, Thermo UPLC, Duo LC, and LTQ platforms and Waters UHPLC and QDa.
- Work closely with members of the RNAi chemistry and analytical teams to understand and validate requirements for sample quality control and oligo developability.
- Analyze and interpret experimental data, applying a strong understanding of key parameters required for accurate and reliable data reduction.
- Independently execute assigned responsibilities including Corrective and Preventive Actions (CAPA), system suitability testing (SST), and Analytical Quality Management (AQM), and the development, chemical stability study, accelerated stability evaluation and refinement of quality control methods.
- Engage in technical discussions with project leaders and clients to propose alternative approaches, investigate new methodologies and contribute to problem solving strategies.
- Maintain and operate standard laboratory equipment including centrifuges, pipettes, spectrophotometers, ELISA readers, as well as specialized equipment necessary to support the laboratory.
- Independently operate work related software, including instrument specific software for capturing and analyzing data, Microsoft Office, LIMS, and electronic laboratory notebooks.
- Detailed record keeping of daily experiments in ELNs.
- Comply with clients and company management systems in accordance with appropriate regulatory agencies.
- Follow guidelines set forth by clients and in the company Quality, Health, Safety and Environmental policies and procedures.
- Perform other essential tasks, projects, and responsibilities as required.
- Other duties as defined by manager, department needs and workload.
Skills & Proficiencies:
- Experience in developing new chromatographic methods (LC-UV and LC-MS).
- LCMS/HPLC/Mass Spec familiarity required.
- Experience with analytical instrumentation such as Agilent LC-MS and UPLC, Thermo UPLC, LTQ and Orbitrap, Wates UHPLC, QDA and RDa, etc is a plus.
- Drug formulation experience is a plus.
- Strong analytic thinking skills. Demonstrated ability to articulate issues and extract and synthesize complex issues into key focus.
- Strong interpersonal and communication skills. Proven record to collaborate and network across a wide variety of functions and work effectively with internal and external partners.
- Excellent organizational skills with the ability to work in a fast-paced team environment, meet deadlines, maintain detailed documentation, and prioritize work on multiple projects.
- Strong written and oral communication skills including the ability to communicate effectively in a group setting with colleagues and clients.
- Multitasking, ability to organize and prioritize workload to meet or exceed deadlines.
- Individual and Team work ethic.
- Positive attitude, self-motivated, high level of engagement.
- Ability to understand and follow safety procedures.
- Champions company values including team engagement.
Education and Experience:
- Degree requirement: Master's Degree with 4+ years experience in Analytical Chemistry, Chemistry, Biochemistry or closely related field
- Research experience in designing, validating, performing and analyzing in vitro experiments
Compensation Range: $45.00-$51.00 per hour (e.g., the job posting is not necessarily reflective of actual compensation that may be earned, and actual compensation is subject to variation due to such factors as location, education, experience, and skillset).
