In Discovery Pharmaceutics and Analytical Sciences, you will impact the lives of patients by working with multidisciplinary research teams to help discover novel, efficacious and safe therapeutics. BMS is looking for a motivated Scientist with a desire to contribute to the fast-paced discovery matrix environment by conducting biophysical characterization and preformulation studies for potential new biologic candidates. The ideal candidate will have a strong understanding of analytical techniques for large molecules, as well as biophysical properties of new biologic candidates as they relate to compound liability and developability profiles.
The successful candidate will be expected to apply emerging digital and AI-enabled approaches, where scientifically appropriate, to strengthen biologics candidate assessment, improve experimental design, accelerate data interpretation, and enhance decision-making in discovery pharmaceutics and analytical sciences.
Job Responsibilities- Carry out and interpret biophysical characterization and preformulation studies on potential new biologics candidates, with the purpose to define their developability and liability profiles to support candidate assessment and nomination.
- Provide experimental, computational, and AI-enabled input to protein discovery scientists during design and screening of new biologics entities, using appropriate predictive models, data mining approaches, and informatics tools to support lead optimization, candidate identification, characterization, and selection.
- Strategically design and guide the development of formulations suitable for use in drug discovery pharmacology studies, PK studies and initial exploratory toxicology studies.
- Work with discovery teams to enable drug discovery through application of innovative drug delivery technologies, devices, and data-driven or AI-enabled approaches, internally and externally, to support more effective delivery of biologics.
- Contribute to and help shape the strategic direction of Discovery Pharmaceutics & Analytical Sciences, strengthening its role as a problem-solving partner for biologics discovery teams and enabling seamless transfer of candidates to development.
- Advance the capabilities of the larger candidate optimization organization by developing scientific expertise that strengthens understanding of how biophysical properties influence overall biopharmaceutical performance of proteins, antibodies, and other large molecule modalities.
Job Requirements/Education- Ph.D. with 0-2 years of experience or MS with 3+ years of experience in or Bachelors with 5+ years of experience in Pharmaceutics, Biochemistry, Chemistry, Pharmaceutical Chemistry, Molecular Biology, Bioengineering, Chemical Engineering or related disciplines.
- Knowledge of basic protein chemistry and biopharmaceutical principles as they apply to drug discovery and drug delivery of proteins, antibodies and other large molecule modalities is required.
- Understanding of biophysical properties and analytical methods used for characterization of proteins and other large molecules and how they relate to the biologics' in vivo delivery and disposition is required.
- Experience in protein and peptide chromatography, including application of various UPLC/HPLC modes, mass-spectrometry-based protein footprinting techniques, peptide mapping, glycosylation and PTM analysis of proteins.
- Strong understanding of preformulation aspects for proteins, antibodies and other large molecules is necessary, along with ability to guide the generation and interpretation of preformulation data as it relates to the overall discovery process.
- An understanding of drug delivery technologies and devices and their assessment relative to the delivery of biologics is desired.
- Strong written and verbal communication skills are required.
- Excellent interpersonal skills and demonstrated effectiveness as a team player on multidisciplinary teams resourced in a flexible, global environment are required.
- The ability to think innovatively and reduce such thinking to practical implementation to enable the discovery and design of new biologics entities is desired.
- Demonstrated ability to use digital, computational, and AI-enabled tools for experimental planning, data analysis, visualization, literature and knowledge mining, and scientific communication is highly desirable.
- The candidate should demonstrate sound scientific judgment in the use of AI-enabled tools, including awareness of data quality, model limitations, reproducibility, documentation, confidentiality, and appropriate human review of AI-assisted outputs.
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Compensation Overview:Princeton - NJ - US: $101,800 - $123,353
The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.
Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:
- Health Coverage: Medical, pharmacy, dental, and vision care.
- Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
- Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include:Paid Time Off
- US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
- Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.
On-site ProtocolBMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
