Roche

Scientist 2

Roche$87K — $161K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • B.S. or M.S. in biochemistry, molecular biology or biological sciences with relevant lab experience (3-4 years for B.S. or 2 years for M.S.)
  • Hands-on experience with protein purification using AKTA/FPLC systems
  • Experience handling large sample sizes with a focus on accuracy and data integrity
  • Basic understanding of antibody structure and function
  • Commitment to continuous learning and expanding technical skills
  • Strong documentation skills and attention to detail.

Responsibilities

  • Execute high-throughput protein production workflows for various therapeutic molecules
  • Manage purification operations for mid-to-large expression volumes
  • Perform automated protein purification workflows using AKTA systems with various affinity resins
  • Conduct routine QC testing to assess protein purity and integrity
  • Maintain lab operations by preparing consumables and performing equipment care
  • Scale production processes through planning and protocol optimization
  • Document experimental data and present findings to the department.

Benefits

  • Access to a comprehensive benefits package
  • Opportunity for a discretionary annual bonus based on performance
  • Support for continuous learning and technical skill development
  • Work within a dynamic and collaborative team environment.
  • Engagement with advanced protein production technologies.
Full Job Description
Scientist 2

The Opportunity


  • Execute high-throughput protein production workflows supporting antibody, bispecific and multi-specific molecules.
  • Manage high-throughput purification operations across a range of mid-to-large expression volumes.
  • Perform automated and semi-automated protein purification workflows using AKTA system- utilizing various types of affinity resins, polishing steps, along with quality assessment, to yield fit-for-purpose therapeutic molecules.
  • Execute routine QC testing using SEC (HPLC) to evaluate purity, monomer content, and aggregation, while providing cross-functional support for concentration, endotoxin, and SDS-PAGE assays and LC/MS.
  • Maintain seamless lab operations by formulating buffers, preparing consumables, packing chromatography columns, and performing preventive instruments care.
  • Scale production processes through strategic planning and protocol optimization to meet quality and timeline target.
  • Interact with informatics systems, document experimental data, procedures, and present findings to the department.

Who You Are


  • B.S. or M.S. in biochemistry, molecular biology or biological sciences. Applicants with B.S. should have at least 3 to 4 years, with M.S. should have at least 2 years of industry lab work experience.
  • Demonstrated hands-on experience with protein purification using AKTA/FPLC system.
  • Demonstrated wet-lab expertise in handling large sample numbers with exceptional accuracy and data integrity.
  • A basic understanding of antibody structure and function.
  • Passionate about continuous learning, technical skill expansion, and adopting advanced protein production platforms.
  • Strong documentation habits, attention to detail, and ability to juggle multiple tasks in parallel.

Preferred Skills, Knowledge and Qualifications


  • Experience with lab automation or liquid handler is a plus.
  • Familiarity with mammalian expression systems (CHO/HEK) and transient transfection at scale.

Relocation benefits are not available for this posting.


The expected salary range for this position based on California is 87 000,00 - 161 600,00 USD Annual Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance.  This position also qualifies for the benefits detailed at the link provided below.


About Roche

Roche Holding AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has bearer shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the largest pharmaceutical company in the world, and the leading provider of cancer treatments globally. The company also produces a range of diagnostic tests for medical professionals and patients. Roche was one of the first companies to bring targeted treatments to patients. In 2019, Roche had over 100,000 employees worldwide, and generated revenue of CHF 61.5 billion.
Learn more about Roche
Size
100,920 employees
Industry
NASDAQ

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