The Scripps Research Institute

Research Scientist, Peptide Chemistry

The Scripps Research Institute$77K — $95K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • Master's degree with 5+ years of industry experience or Bachelor's degree with 10+ years experience
  • Ph.D or postdoc in chemical or biological sciences preferred
  • 1-4 years of relevant experience in academia or biotechnology/pharmaceutical sectors
  • Proficient in contemporary peptide synthesis and analytical characterization techniques
  • Strong understanding of peptide/protein structure and biophysical assessment techniques

Responsibilities

  • Lead peptide drug discovery and development, focusing on long-acting peptides and conjugates
  • Collaborate in a multidisciplinary team to identify and advance promising compounds
  • Apply medicinal chemistry principles to optimize peptide candidates for extended-duration dosing
  • Engage in independent ideation to drive innovative drug discovery practices
  • Review literature to support structure-activity relationships in peptide design

Benefits

  • Eligibility for employer-contributed retirement plans
  • Comprehensive health and welfare plans including multiple medical options
  • Access to Flexible Spending Accounts for medical and dependent care
  • Competitive vacation and sick leave policies
  • On-site counseling services for employees and family members
  • Free on-site parking
Full Job Description
POSITION TITLE:Research Scientist

POSITION SUMMARY:

We are seeking an experienced and highly skilled Peptide Chemist to join our dynamic team in San Diego. The ideal candidate will possess exceptional academic credentials in peptide medicinal chemistry, along with expertise in formulation strategies for peptide therapeutics.

In this role, the successful applicant will be a key member of the laboratory, contributing to the design and synthesis of peptide analogs intended to enhance the potency, pharmacokinetics, stability, and in vivo efficacy of potential drug candidates, with a particular focus on long-acting injectable formats.

The candidate will have ample opportunity to participate in multidisciplinary drug discovery projects, engage in independent ideation, and help drive innovative practices that accelerate peptide drug discovery efforts. This role offers strong potential for career growth in a collaborative, cutting-edge environment.

RESPONSIBILITIES:

  • Play a leadership role in peptide drug discovery and development efforts, contributing to the advancement of long-acting peptides and peptide conjugates into effective clinical candidates.
  • Participates in a multidisciplinary team committed to the expeditious identification of development compounds and advancing discovery projects through critical preclinical stage gates.
  • Apply medicinal chemistry and formulation principles to optimize peptide candidates for extended-duration dosing.


REQUIREMENTS:

  • Master's degree with a minimum of 5 years of relevant industry experience, or Bachelor's degree with 10+ years of experience.
  • Ph.D and/or postdoc in chemical or biological sciences with a strong focus on peptide chemistry is preferred.
  • 1-4 years of experience in academia or a biotechnology/pharmaceutical company.
  • Skilled in contemporary peptide synthesis techniques, and analytical characterization of peptides and proteins.


ADDITIONAL PREFERENCES:

  • Strong understanding of peptide and protein structure and associated biophysical techniques to assess structure, stability and behavior in solution.
  • Experience in bioconjugation, time-extension and formulation strategies for peptides and proteins.

  • Review research papers and intellectual property literature in support of SAR of peptide drug design and/or delivery.

  • Demonstrated ability to work independently as well as in cross-functional team
  • Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency

  • Self-motivated, strong work ethic, independent and results oriented.


PHYSICAL REQUIREMENTS:

This position works in a laboratory environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

COMPENSATION:

The expected hiring range for this position is $77,000 - $95,000 per year, commensurate with experience. Consideration will be given to experience that exceeds the listed requirements.

COMPREHENSIVE BENEFITS INCLUDE:

  • Eligibility for retirement plans with employer contribution.
  • Full suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more.
  • Access to Flexible Spending Accounts (Medical/Dependent Care).
  • Competitive vacation and sick leave policies.
  • Free, on-site Counseling Center which provides confidential counseling services to benefits-eligible employees and their family members.
  • Free, on-site parking.


The above statements describe the level of work performed and expected in general terms. The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice. Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff.

About The Scripps Research Institute

The Scripps Research Institute (TSRI) is a non-profit biomedical research organization that focuses on basic and applied research in the areas of biology, chemistry, and medicine. The institute was founded in 1924 by philanthropist Ellen Browning Scripps and is headquartered in La Jolla, California, with additional campuses in Jupiter, Florida and San Diego, California. TSRI employs over 3,000 scientists, technicians, and administrative staff, and has partnerships with numerous academic and industry organizations. The institute's research has led to the development of new drugs and therapies for a variety of diseases, including cancer, Alzheimer's, and HIV/AIDS.
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