Job DescriptionLawrence Livermore National Laboratory (LLNL) is seeking a highly motivated
Protein Production and Purification - Fermentation Scientist to support an interdisciplinary project focused on developing protein-based methods for rare earth separation. You will support the development and optimization of scalable fermentation processes for microbial protein expression and in developing and optimizing cost-effective downstream protein purification methods. This position requires strong experimental skills, attention to detail, and the ability to work effectively as part of a multidisciplinary team of scientists and engineers.
This position requires full-time on-site presence.
In this role you will:- Operate and maintain laboratory-scale bioreactors for microbial protein expression.
- Support the development, optimization, and execution of fermentation processes at bench and pilot scale.
- Develop, optimize, and refine downstream protein purification methods (e.g., chromatography, filtration, protein immobilization).
- Analyze experimental data and apply data-driven approaches to improve yield, productivity, and reproducibility
- Maintain detailed and accurate laboratory records; contribute to data analysis,summarize and communicate results to project teams.
- Support laboratory operations including equipment maintenance, media preparation, and safety compliance.
- Collaborate with scientists and engineers to troubleshoot workflows and support scale-up efforts.
- Perform other related duties as assigned.
Qualifications- Bachelor's degree in Biological Sciences, Biochemistry, Bioengineering, Chemical Engineering, or a related field.
- Hands-on experience independently conducting microbial fermentation experiments in bioreactorsat the bench or pilot scale
- Experience with protein purification and downstream process optimization.
- Proficiency in sterile techniques and basic microbiology procedures.
- Strong problem-solving, analytical, and organizational skills.
- Ability to work independently and collaboratively in a multidisciplinary team.
- Strong written and verbal communication skills.
Qualifications we desire:- Experience with large-scale bioreactors (≥50L) and process scale-up.
- Experience with optimizing protein expression in bioreactors.
- Experience with column chromatography systems
- Familiarity with molecular biology techniques (PCR, cloning, expression construct design).
Pay Range$146,340 - $185,544 annually
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting; pay will not be below any applicable local minimum wage. An employee's position within the salary range will be based on several factors including, but not limited to, specific competencies, relevant education, qualifications, certifications, experience, skills, seniority, geographic location, performance, and business or organizational needs.
Additional Information#LI-Onsite
Position InformationThis is a Flexible Term appointment, which is for a definite period not to exceed six years. If final candidate is a Career Indefinite employee, Career Indefinite status may be maintained (should funding allow).
Why Lawrence Livermore National Laboratory?- Included in 2026 Best Places to Work by Glassdoor!
- Flexible Benefits Package
- 401(k)
- Relocation Assistance
- Education Reimbursement Program
- Flexible schedules (*depending on project needs)
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Security ClearanceNone required. However, if your assignment is longer than 179 days cumulatively within a calendar year, you must go through the Personal Identity Verification process. This process includes completing an online background investigation form and receiving approval of the background check.
National Defense Authorization Act (NDAA)The 2025 National Defense Authorization Act (NDAA), Section 3112, generally prohibits citizens of China, Russia, Iran and North Korea without dual US citizenship or legal permanent residence from accessing specific non-public areas of national security or nuclear weapons facilities. The restrictions of NDAA Section 3112 apply to this position. To be qualified for this position, Candidates must be eligible to access the Laboratory in compliance with Section 3112.
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