About the Role
We are seeking a Principal Scientist to serve as a translational and strategic leader within our
Oncology research organization. This role sits at the crossroads of reverse translation, biomarker
science, and cutting-edge genomics technology - driving mechanistic insight from the clinic
back into discovery to accelerate and de-risk our oncology pipeline. The ideal candidate brings
deep expertise in cancer biology, a track record of cross-functional leadership in a pharma or
biotech environment, and hands-on experience building and deploying single cell and spatial
omics capabilities.
What You'll Do
Discovery & Translational Research Leadership
• Drive discovery and translational projects in collaboration with AI and internal research
teams with a primary focus on integrating scRNA-seq and spatial biology into Natera's
pipeline.
• Collaborate with external translational teams on building single-cell and spatial biology
workflows into their early phase clinical studies.
• Leverage novel technologies to inform collaborative reverse and forward translation
efforts as well as internal target discovery and validation projects.
• Design and execute lab-based research programs that bridge clinical observations with
mechanistic hypotheses, supporting asset progression and CDP expansion
Technology & Capabilities
• Lead and contribute to technology area team focused on single cell genomics and spatial
omics, building out multiomics capabilities to support foundational models and RWD
efforts
• Partner with internal and external collaborators to establish, optimize, and deploy cutting-
edge platforms for translational applications
• Serve as an internal expert and thought leader on emerging genomics technologies
relevant to oncology drug discovery and development
Cross-Functional & Strategic Engagement
• Represent translational science on life cycle, RWD, and BioPharma BD teams
• Collaborate with Clinical, Biomarker, Discovery, and Regulatory colleagues to shape
clinical trial design and biomarker plans
• Build and maintain external scientific partnerships and advisory relationships as
appropriate
People & Team Development
• Lead and mentor a team of scientists and contractors, with a strong commitment to career
development and scientific growth
• Foster a collaborative, high-performance team culture with clear goals and accountability
Position Requirements
• Ph.D. in Cancer Biology, Molecular/Cellular Biology, Immunology, Bioengineering, or a
closely related field
• 6+ years of experience post-Ph.D. in oncology translational research within biotech or
pharma, including demonstrated growth into senior or principal scientist roles
• Deep scientific expertise in at least one of the following: cancer cell biology, tumor
immunology, cell engineering, or neoantigen biology
• Hands-on experience with single cell genomics, spatial transcriptomics, or multiomics
platforms; experience building or scaling these capabilities in an organizational context is
strongly preferred
• Strong publication and/or patent record reflecting independent scientific contribution
• Demonstrated experience leading cross-functional programs and influencing without
authority across Research, Clinical, and Biomarker teams
• Prior experience managing and mentoring scientists at multiple career stages
• Exceptional scientific communication skills; ability to synthesize complex data and
present compellingly to diverse audiences
The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.
Remote USA
$171,900-$214,950 USD
Compensation & Total Rewards This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.
This position is also eligible for additional compensation and benefits through Natera's robust Total Rewards program, including:
- Annual performance incentive bonus
- Long-term equity awards
- Comprehensive health benefits (medical, dental, vision)
- 401(k) with company match
- Generous paid time off and company holidays
- Additional wellness and work-life benefits
Compensation Range
$171,900-$214,950 USD
