Aktis Oncology is seeking a highly motivated Principal Scientist to support manufacturing and assay development of AKTIS Oncology's proprietary radiopharmaceutical drug products. The Principal Scientist lead a small team of scientists and participate in the manufacturing and formulation optimization of Aktis' clinical candidates within the RPD group and provide subject matter expert support of regulatory packages. This role is critical in ensuring product quality, regulatory compliance, and successful advancement of radiopharmaceutical programs from early development through clinical manufacturing phases. The position will collaborate closely with cross-functional team members to ensure timely delivery of robust manufacturing protocols in support of technology transfer activities. The ideal candidate has hands-on experience in radiolabeling and handling radioactive materials and radiopharmaceutical analytical techniques. This role requires full-time on-site presence at the Aktis Boston office. RESPONSIBILITIES This role will drive several areas of strategic importance to Aktis: • Lead a team to execute radiolabeling and formulation development of Aktis' radioactive drug products for clinical use • Support and execute the manufacturing development strategies from RPD department head • Participate in day-to-day laboratory operations, including radiation safety • Lead and support development activities at external Contract Research Organizations • Write development reports that can be used for transfer of technology and regulatory filing • Take on new challenges willingly and build a culture of rigor and data-driven decision making to bring novel therapies to the clinic. • Demonstrate high standards for scientific rigor, team behaviors, excellence and a culture of innovation that is fully aligned with company objectives • Operate and maintain fume hoods, radio-HPLC systems, detectors, and analytical instruments QUALIFICATIONS • Minimum of an advanced degree in chemistry, engineering or related field. • Minimum of seven years of relevant industry experience • Experience in leading scientific laboratory teams and external project management • Hands-on experience with metal chelation chemistry, radiolabeling methods and handling radioactive materials. • Experience analyzing radiolabeled compounds, experience with gamma detectors, UV- and radio-HPLC • Experience with protein solubility, binding assays, and drug product formulation • Project management and organizational skills, proven track record of setting priorities, and ability to work independently and as a team leader. • Strong desire to be part of a mission-oriented company leading transformative change for patients. • Proven demonstration of transparent communication and fostering open and diverse debate. • Ability to work with agility and manage ambiguity. • Personifies positive energy and exemplifies respect.