Principal Scientist

Leidos Holding$116K — $210K *
Pharmaceuticals & Biotech
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • BS in Chemistry or related field with 13+ years of experience, or Master's with 10+ years of experience.
  • Deep understanding of technical principles in synthetic chemistry and nanomaterials engineering.
  • Strong team player with excellent communication skills across diverse disciplines.
  • US Government Secret Security Clearance is required.

Responsibilities

  • Execute laboratory work for unclassified and classified projects.
  • Support program capture initiatives for various organizations, including ARPA-Health.
  • Communicate research findings in meetings and through reports and publications.
  • Adapt quickly to changing research demands and acquire new scientific knowledge.
  • Collaborate with a multidisciplinary team including biologists, chemists, engineers, and materials scientists.

Benefits

  • Opportunities for advanced career growth.
  • Collaborative work environment focused on innovation.
  • Involvement in cutting-edge research projects.
  • Support for business development and technical strategy.
Full Job Description

This is where your legacy begins! The Chemical, Biological and Materials Sciences (CB&MS) Division in the Defense Sector at Leidos currently has an opening for a Principal Scientist to work in our San Diego, CA office. We have an immediate need for an experienced and highly motivated scientist to support the technical efforts of ongoing contracts as well as support the capture of new programs.

Primary Responsibilities:

  • The candidate will play an active role in the laboratory work execution of unclassified and classified efforts as well as supporting the capture of programs within various organizations, including ARPA-Health.
  • In addition, the candidate will support the division on day-to-day technical and business development operations
  • Interface with key stakeholders by effectively communicating research in Government customer meetings, internal meetings, and through progress reports, peer-reviewed publications, and/or patents.
  • Quickly adapt to evolving research needs and rapidly acquire new scientific knowledge to stay informed on new, emerging technologies.
  • Work effectively as a member of a fast-paced multidisciplinary team consisting of biologists, chemists, engineers (e.g., electrical, mechanical, or software), and materials scientists. Candidates should follow sound scientific practices and maintain effective documentation of activities and analyses.

Basic Qualifications:

  • BS degree in Chemistry or related fields and >13 years of prior relevant experience, or (preferably) Master’s degree with 10+ years prior relevant experience.
  • Has in-depth understanding of technical principles, theories, concepts and their application across a range of programs, and is able to serve as a subject matter expert in synthetic chemistry and nanomaterials engineering.
  • Team-oriented with excellent written and verbal communication skills; ability to interact with people from diverse areas and disciplines
  • Must possess a US Government Secret Security Clearance.

Preferred Qualifications:

  • Synthetic chemistry, nanomaterials, and/or biology expertise with demonstrated experience in the development, optimization, validation, and troubleshooting of new technologies.
  • Demonstrated experience in contributing to business capture activities for government contracts.
  • Ability to develop technical approaches, define analytical strategies, and translate customer requirements into practical laboratory solutions.
  • Familiarity with working in a fast-paced milestones-driven environment.

NKE

If you're looking for comfort, keep scrolling. At Leidos, we outthink, outbuild, and outpace the status quo — because the mission demands it. We're not hiring followers. We're recruiting the ones who disrupt, provoke, and refuse to fail. Step 10 is ancient history. We're already at step 30 — and moving faster than anyone else dares.



Original Posting:
August 14, 2026

Pay Range:
Pay Range $116,350.00 - $210,325.00

The Leidos pay range for this job level is a general guideline onlyand not a guarantee of compensation or salary. Additional factors considered in extending an offer include (but are not limited to) responsibilities of the job, education, experience, knowledge, skills, and abilities, as well as internal equity, alignment with market data, applicable bargaining agreement (if any), or other law.

About Leidos Holding

Leidos Holding Careers

Joining Leidos Holding presents an unparalleled opportunity to advance one's career with a leader in innovation and technology. The company offers a plethora of job opportunities aimed at fostering professional growth and development in a diverse and inclusive environment.

Explore Career Opportunities

Leidos Holding is actively seeking skilled professionals who are passionate about leveraging their expertise to drive innovation and leadership in their fields. With a variety of open positions, Leidos Holding provides a platform for individuals to challenge themselves in a dynamic work environment.

Innovation and Professional Growth

At Leidos Holding, innovation is at the core of everything they do. Employees are encouraged to think creatively and push boundaries. The company supports this drive for innovation through comprehensive professional development and diversity training programs that are designed to enhance skills and foster leadership.

Commitment to Diversity and Inclusion

Leidos Holding is committed to creating a workplace where diversity is not only recognized but celebrated. With a culture that values and promotes diversity, Leidos Holding ensures that all team members have the opportunity to contribute, learn, and grow.

Internship Programs

For those starting their career, Leidos Holding offers internship programs that provide a robust foundation in the industry. Internships are a great way to develop essential skills, gain valuable work experience, and build professional networks.

Benefits and Culture

Employees at Leidos Holding enjoy a range of benefits designed to support their professional and personal lives. The company culture is built on a foundation of respect and integrity, providing a supportive and collaborative environment where every team member is valued.

Join the Team

Leidos Holding is hiring! Explore job opportunities that match your skills and interests. Leidos Holding looks for driven, curious, and innovative individuals to join their team. Positions are available across various disciplines and experience levels.

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To prepare for an interview at Leidos Holding, candidates should familiarize themselves with the company's missions and values, update their resumes, and be ready to discuss how their background and skills align with the position they are applying for.

Networking and Career Advancement

Leidos Holding encourages its employees to engage in networking within the company to discover new opportunities for career advancement. The leadership team at Leidos Holding is dedicated to supporting employees in their career paths with ample opportunities for networking and growth.

Explore Leidos Holding Jobs and Careers

Discover the exciting career opportunities at Leidos Holding today. With a commitment to employee growth, innovation, and diversity, Leidos Holding is the perfect place to advance your career. Check out the latest job listings and find your perfect fit at Leidos Holding.

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