Eli Lilly

Postdoctoral Scientist

Eli Lilly$58K — $123K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • Ph.D. in analytical chemistry, chemical biology, biochemistry, or related field (degree must be conferred or expected by June 2026)
  • Hands-on experience with mass spectrometry techniques for protein characterization
  • Understanding of bioconjugation chemistry and DAR quantitative analysis
  • Strong scientific communication skills with a record of peer-reviewed publications
  • Authorization to work in the U.S. on a full-time basis (no visa sponsorship)

Responsibilities

  • Develop and optimize high-throughput mass spectrometry workflows for protein bioconjugates
  • Execute large-scale compound screening campaigns using automated mass spectrometry platforms
  • Generate analytical datasets to support AI/ML-driven bioconjugation predictions
  • Collaborate with medicinal chemists to advance biotherapeutic constructs
  • Partner with data science and automation teams to build scalable data workflows
  • Present research findings at scientific forums and contribute to publications
  • Maintain electronic laboratory records and adhere to safety standards

Benefits

  • Eligible for company bonus based on performance
  • Participation in company-sponsored 401(k) plan
  • Access to health, dental, and vision benefits
  • Flexible spending accounts for healthcare and dependent care
  • Vacation benefits and various leave of absence options
  • Well-being benefits including an employee assistance program and fitness initiatives
Full Job Description
Role Overview

We are seeking a highly motivated and creative post-doctoral scientist to join the cross-functional Chemistry + Mass Spectrometry team within BioTDR (biologic discovery) at our San Diego site. This role sits at the intersection of analytical chemistry, bioconjugation, and AI/ML-driven discovery, supporting a high-impact research program to develop a next-generation bioconjugation platform for antibody-drug conjugates (ADCs), antibody-oligonucleotide conjugates (AOCs), and peptide conjugates.

In This Role, You Will

  • Develop and optimize high-throughput mass spectrometry workflows for analytical characterization of protein bioconjugates, including intact mass analysis, drug-to-antibody ratio (DAR) determination, and site-specific modification profiling by peptide mapping.
  • Execute large-scale compound screening campaigns using automated LC-MS and other mass spec platforms to evaluate novel bioconjugation chemistries.
  • Generate high-quality structured analytical datasets to support computational modeling and AI/ML-driven prediction of bioconjugation outcomes.
  • Work with medicinal chemists to characterize and advance lead conjugation chemistries into functional biotherapeutic constructs across relevant modalities.
  • Partner with computational, automation, and data science teams to build integrated, scalable workflows for high-throughput data acquisition and analysis.
  • Present research findings at internal and external scientific forums and contribute to peer-reviewed publications and intellectual property filings.
  • Maintain rigorous electronic laboratory records and uphold Lilly safety and compliance standards.


Basic Qualifications

  • Ph.D. in analytical chemistry, chemical biology, biochemistry, bioconjugation chemistry, or a closely related field (degree conferred or expected by June 2026).
  • Demonstrated hands-on experience with mass spectrometry for protein or biotherapeutic characterization (intact LC-MS and/or peptide mapping LC-MS/MS).
  • Experience with or strong understanding of bioconjugation chemistry and quantitative analysis of DAR.
  • Strong scientific communication skills and a record of peer-reviewed publication.
  • Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.


Additional Skills / Preferences

  • Proficiency with Thermo and Agilent LC/MS systems and their software tools for protein MS data analysis.
  • Experience with high-throughput screening workflows and laboratory automation platforms.
  • Familiarity with structural biology methods
  • Excellent interpersonal skills and demonstrated ability to work effectively in cross-functional, interdisciplinary teams.
  • Self-motivated and adaptable, with a track record of creative problem-solving and intellectual initiative.


Additional Information

  • Location: Lilly BioTDR, San Diego, CA (on-site).
  • Duration: Fixed term, 2 years with potential extension up to 3 years.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$58,000 - $123,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

About Eli Lilly

ICOS Corporation is a biotechnology company that engages in the discovery, development, and commercialization of therapeutic products. It is engaged in the commercialization of treatments for unmet medical conditions, such as benign prostatic hyperplasia, hypertension, pulmonary arterial hypertension, cancer, and inflammatory diseases. It is the developer of a treatment known as Cialis (tadalafil), a product for the treatment of erectile dysfunction through its joint venture with Eli Lilly and Company in North America and Europe. It is also engaged in contract manufacturing services for third parties. It is in a strategic alliance with Solvay Pharmaceuticals, Inc. ICOS Corporation was established in 1989, based in Bothell, Washington. It is currently operated by Eli Lilly and Company.

Eli Lilly Careers

Joining Eli Lilly offers an unparalleled opportunity to become part of a leading global team dedicated to creating a healthier future. As a company revered for its commitment to innovation and leadership in the pharmaceutical industry, Eli Lilly is where your professional journey can flourish. Work You’ll Do At Eli Lilly, we are passionate about transforming patient care and advancing medical innovation. Our team at Eli Lilly is at the forefront of developing groundbreaking solutions in healthcare. By joining us, you will collaborate with some of the brightest minds in the industry, using cutting-edge technology to make real-world impacts. Lead with Innovation and Leadership Eli Lilly stands out in the marketplace by integrating deep industry expertise with robust research and development efforts. We are looking for professionals who are eager to drive change and lead the way in developing therapeutic breakthroughs. Explore Job Opportunities and Growth Eli Lilly offers a variety of career paths, including full-time positions and internships, across multiple functions such as research, marketing, IT, and sales. Whether you are a seasoned professional or a recent graduate, Eli Lilly provides an environment that promotes career growth and learning opportunities. Our commitment to diversity and leadership training ensures that every employee can achieve their potential. Be Part of Our Team Our team at Eli Lilly is committed to excellence and driven by a mission to improve lives. Employees enjoy a supportive culture that values collaboration, creativity, and diversity. We believe that a diverse workforce fosters innovation and helps us better connect with the communities we serve. Benefits and Culture Eli Lilly is dedicated to supporting our employees, offering competitive benefits, wellness programs, and comprehensive health care. Our culture is built on a foundation of respect, integrity, and quality, making Eli Lilly not just a great place to work, but a community to grow with. Networking and Professional Development Eli Lilly encourages continuous professional development and networking. With access to various training programs and mentorship opportunities, employees can enhance their skills and advance their careers. Our leadership is committed to nurturing talent through effective training and development strategies. Join Our Team Discover the exciting job opportunities at Eli Lilly by exploring open positions that match your skills and interests. We are continuously hiring and looking for individuals who are passionate, innovative, and ready to contribute to our mission of making life better for people around the globe. Stay Connected Keep up to date with the latest at Eli Lilly by following our careers blog. Gain insights from industry leaders and get tips on everything from crafting the perfect resume to preparing for your interview. Eli Lilly is not just a company—it's a place where you can make a difference. Explore the positions available and find out how your talents can help change the world. SEARCH ELI LILLY JOBS Stay ahead in your career with Eli Lilly, where innovation, leadership, and a commitment to diversity and growth lead the way to future advancements.
Learn more about Eli Lilly
Size
35,000 employees
Market Cap
$344.2 billion
Industry
Net Income
$6.1 billion
Founded
1876
5 Year Trend
+5.9%
Revenue
$24.5 billion
NASDAQ

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