What you will do

The Post Doctoral Fellow at Amgen conducts research under the supervision of a mentor. They contribute to the design and execution of research projects, the analysis of data, and the preparation of scientific manuscripts.

Position Overview

This postdoctoral project focuses on understanding how biochemical state, cellular context, and subcellular localization influence substrate recruitment to E3 ligases such as Cereblon (CRBN). The fellow will leverage cutting-edge in-cell proximity labeling technologies (TurboID), quantitative proteomics, and cellular perturbation approaches to define mechanistically meaningful recruitment events relevant to molecular glue discovery.

The position is ideal for candidates with strong training in cell biology, molecular biology, or biochemistry, particularly in ubiquitin biology, targeted protein degradation, or E3 ligase biology, who are interested in applying proteomics approaches to mechanistic questions in targeted protein degradation.

Prior hands-on proteomics expertise is not required; however, familiarity with proteomics approaches and enthusiasm for learning advanced quantitative proteomics methodologies are highly desirable.

Key Responsibilities

• Design and execute cellular and biochemical experiments to study molecular glue–mediated E3 ligase recruitment
• Develop and apply proximity labeling and targeted perturbation strategies in engineered cellular systems
• Investigate context-dependent recruitment mechanisms involving post-translational modifications, protein complexes, and subcellular localization
• Collaborate closely with proteomics scientists to generate and interpret quantitative mass spectrometry datasets
• Integrate biological and proteomic datasets to develop mechanistic models of induced proximity biology
• Present findings and contribute to the preparation of scientific manuscripts, publications, and scientific communications.

Basic Qualifications

• PhD completed prior to start date in Cell Biology, Molecular Biology, Biochemistry, Chemical Biology, Immunology, Cancer Biology, or related discipline

Preferred Qualifications

• Strong background in cell and molecular biology with demonstrated experimental independence
• Experience in ubiquitin biology, E3 ligases, targeted protein degradation, or induced proximity biology
• Experience with mammalian cell culture, CRISPR engineering, protein interaction studies, or signaling biology
• Familiarity with proteomics or mass spectrometry-based approaches

• Strong publication record, including first-author publications in high-impact peer-reviewed journals

• Strong communication and collaborative skills

Scientific Environment

The fellow will join a highly collaborative environment at the intersection of proteomics, TPD biology, and translational drug discovery. The project leverages established high-throughput TurboID proximity labeling workflows, advanced quantitative proteomics platforms, and close collaborations across discovery biology and proteomics teams.

This position offers outstanding opportunities for scientific growth in induced proximity biology, quantitative proteomics, and translational therapeutic discovery, with expected authorship on high-impact publications.

Salary Range