Postdoctoral Fellow

Let’s do this. Let’s change the world. In this vital role you will generate mechanistic insights that directly influence analytical control strategy, molecule design, and formulation development across Amgen's pipeline.

• Design and execute MS-based mechanistic studies of protein fragmentation pathways in biologics, including stable-isotope solvent-labeling approaches such as D₂O and H₂¹⁸O oxygen-incorporation experiments to distinguish hydrolytic, enzymatic, and chemical fragmentation mechanisms.

• Apply advanced analytical characterization techniques, including mass spectrometry, chromatography, and structural analysis, to identify fragmentation products, map fragmentation sites and characterize reaction intermediates.

• Integrate experimental data with mechanistic and statistical modeling to improve prediction of degradation behavior.

• Translate mechanistic findings into testable hypotheses and practical mitigation strategies, including molecule design (sequence selection), formulation considerations, and storage recommendations.

• Publish findings in high-impact peer-reviewed journals and contribute to intellectual property generation.

• Present research internally and externally at scientific conferences.

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.

Basic Qualifications:

• PhD at time of appointment

Preferred Qualifications:

• PhD at the time of appointment in Analytical chemistry, physical chemistry, or related life sciences disciplines

• Demonstration of independent design, execution, and interpretation of experiments and results, as exemplified by a solid publication record with first-author publication(s)

• Demonstrated expertise with ChemDraw and mechanistic biomolecular chemistry, including the ability to propose, illustrate, and evaluate reaction mechanisms relevant to protein and peptide degradation pathways. Strong understanding of protein chemistry, protein degradation pathways, peptide mapping, and biologics analytical characterization

• Experience with LC-MS/MS, high-resolution mass spectrometry and advanced protein characterization

• Excellent critical thinking, organizational, and communication skills

• Passion to learn and work collaboratively within a large team of scientists with diverse technical and cultural backgrounds

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans

• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship for this role is not guaranteed.

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Salary Range