The University of Pittsburgh is establishing a state-of-the-art, multi-omics facility to support research and clinical translational programs in multiple OMICS disciplines including proteomics, metabolomics, and lipidomics. We are seeking a highly skilled and motivated Senior Scientist for the Mass Spectrometry Facility to oversee day-to-day operations while remaining actively involved in sample processing and instrument analysis. This role combines leadership, technical expertise, and hands-on execution. The selected candidate will oversee mass spectrometry workflows and coordinate staff while working at the bench to ensure high-quality reproducible data generation. 1. Act as the go-to subject matter expert for mass spectrometry, including custom method development, automation initiatives, and troubleshooting to enhance analytical precision and continuous improvements in mass spectrometry-based omics. 2. Ideal candidate should be able to identify erroneous results and execute rapid fault-diagnosis, root-cause identification, and corrective action on mass spectrometers. 3. Perform hands-on work in all aspects of LC-MS/MS workflows, including sample preparation, method development and setup, and data acquisition. 4. Train, mentor, and supervise technical staff; foster a culture of precision, accountability, and teamwork. 5. Collaborate with researchers to design, optimize, and execute mass spectrometry based studies. 6. Ideal candidate should have experience operating, maintaining, calibrating, and troubleshooting mass spectrometers. 7. Maintain accurate records of instrument performance, sample tracking, and results within the Laboratory Information Management System (LIMS). 8. Proven practice in using samples, controls, and standards to create robust reference materials to accurately review and analyze output data. Qualifications
• PhD or Master's degree with 5 years experience in biochemistry, analytical chemistry, or a related field.
• Minimum of 5 years' experience operating and maintaining mass spectrometers.
• Preferably 3 + years in a core facility environment working with Thermo Mass Spectrometry instrumentation, with demostrated experience in method development.
• Proven experience in LC-MS sample preparation, data acquisition, and troubleshooting.
• Demonstrated ability to manage staff and workflow while maintaining personal engagement in laboratory operations.
• Strong organizational, problem-solving, and communication skills.
• A proactive mindset, able to adapt and perform under pressure. Specifically, demonstrate ability to operate in a fast-paced, high-throughput core facility environment.
• Driven and detail-focused scientist who thrives in a collaborative and high-throughput lab environment.
