Boehringer Ingelheim Pharmaceuticals, Inc

Director, Preclinical PKPD Modeling

Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • PhD or equivalent with at least 6 years in Pharmacometrics/Preclinical PKPD modeling, or
  • Master's with 8 years experience, or
  • Professional degree (PharmD, MD) with 7 years experience in similar roles.
  • Minimum of 4 years in drug discovery teams preferred.
  • Proficiency in PMx/PKPD/QSP modeling and empirical/PBPK modeling for NBEs preferred.

Responsibilities

  • Lead the Ridgefield Preclinical PKPD Modeling team, aligning with global objectives.
  • Mentor and develop a PKPD modeling team of up to 5 scientists.
  • Design and implement innovative PKPD modeling approaches focused on NBEs and NTMs.
  • Represent PKPD modeling across multidisciplinary drug discovery teams.
  • Drive adoption of new methodologies and increase visibility of modeling outputs.
  • Deliver high-quality PKPD model results for preclinical studies.
  • Present research findings at scientific meetings and ensure compliance with regulations.

Benefits

  • Collaborative international work environment.
  • Support for employee mobility and networking opportunities.
  • Focus on work-life balance with a healthy working culture.
  • Competitive compensation reflecting the value of employees.
Full Job Description
Description

Join Boehringer Ingelheim as Director Preclinical PKPD Modeling and become a key scientific and managerial leader within our global Drug Discovery Sciences (DDS) organization. In this high-impact role, you will set the strategic vision and inspire a high-performing team, driving innovative PKPD (pharmacokinetic/pharmacodynamic) modeling strategies that enable model-informed decision-making early in drug discovery. You will lead, inspire, and develop the Ridgefield PK/PD modeling team, represent the local Team in a global setting, and collaborate across disciplines to deliver high-quality translational strategies resulting in model-informed human efficacious dose predictions across our portfolio. This is an outstanding opportunity for a visionary leader ready to shape the future of translational modeling and make a difference for patients worldwide.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties & Responsibilities
• Provide leadership for the Ridgefield Preclinical PKPD Modeling team, ensuring alignment with global Preclinical PKPD Modelling and DDS objectives. Set clear goals, prioritize resources, and foster a culture of scientific excellence and innovation.
• Lead, mentor, and develop a diverse team of up to 5 PKPD Modeling scientists. Foster an open, collaborative, and growth-oriented culture through regular feedback, performance reviews, and career development activities. Recruit, onboard, and develop talent to build a highly innovative and impactful modeling team.
• Drive the development and implementation of innovative state-of-the-art PKPD modeling approaches, including empirical, mechanistic, and quantitative systems pharmacology models. Focus on advancing NBEs (new biological entity) and NTMs (new therapeutic modalities) and model-informed translational strategies towards high-quality human efficacious dose predictions.
• Represent PK/PD modeling in multidisciplinary drug discovery project teams and the global Preclinical PKPD Modelling Leadership Team. Build strong partnerships with Discovery Research, Clinical Pharmacology, Biotherapeutics Discovery, and other internal and external stakeholders to ensure seamless integration of modeling expertise across our therapeutic areas (e.g., Immunology & Respiratory, Cardio-Renal-Metabolic, and Oncology Discovery Research).
• Drive the adoption of new modeling methodologies, technologies, and best practices as part of Discovery Research. Develop translational strategies in close collaboration with global teams. Increase the visibility and impact of preclinical PKPD modeling within Boehringer Ingelheim and the broader scientific community.
• Ensure delivery of high-quality PKPD modeling outputs, including study design for preclinical PK, biomarker, and pharmacology studies. Ensure clear communication of results to guide model-informed decision-making in drug discovery and provide a good basis for clinical development teams.
• Present research at internal and external scientific meetings, publish in peer-reviewed journals, and represent the department in committees and forums. Ensure compliance with regulations, SOPs, and company policies, maintaining accurate records and demonstrating fiscal responsibility.

Requirements
• PhD in related field or equivalent area of focus with a minimum of 6 years relevant experience in Pharmacometrics / Preclinical PKPD Modelling in the pharmaceutical industry, regulatory agencies, or academia or
• Master's degree in in related field medicine or equivalent area of focus with a minimum of 8 years relevant experience in Pharmacometrics / Preclinical PKPD Modelling in the pharmaceutical industry, regulatory agencies, or academia or
• Professional degree in pharmacy or medicine (e.g., PharmD, MD, Apotheker, Arzt) with a minimum of 7 years relevant experience in Pharmacometrics / Preclinical PKPD Modelling in the pharmaceutical industry, regulatory agencies, or academia.
• Minimum of 4 years' relevant experience in working in drug discovery teams preferred.
• Proficiency in applying PMx/PKPD/QSP modeling with impact on decision making. Along with experience with empirical and PBPK modeling for NBEs preferred. Deep knowledge of drug discovery process, MID3, and preferentially regulatory guidelines.
• Demonstrated ability to manage projects, influence cross-functional teams, and build effective working relationships.
• Proven leadership and people management skills, with first experience of developing and inspiring scientific teams. In depth scientific and strategic knowledge in the field and knowledge of overall drug discovery process.
• Ability to inspire and motivate a team and focus their energy on achieving business goals.
• Process and performance-oriented, constant drive to develop and implement innovative approaches and processes.
• Ability to challenge processes and procedures, propose changes, and perform contributions to problem solving.
• Excellent communication skills, with a strong publication and presentation record.

Eligibility Requirements
• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post-offer physical (if required).
• Must be 18 years of age or older.

Compensation Data

This position offers a base salary typically between $250,000.00 and $394,000.00 USD. The position may be eligible for a role specific variable or performance based bonus and or other compensation elements. For an overview of our benefits please click here .

About Boehringer Ingelheim Pharmaceuticals, Inc

Boehringer Ingelheim Pharmaceuticals, Inc. is a research-driven pharmaceutical company that discovers, develops, and manufactures prescription medicines. The company's mission is to improve the health and quality of life of patients by developing innovative therapies. Boehringer Ingelheim Pharmaceuticals, Inc. is a subsidiary of Boehringer Ingelheim Corporation, which is headquartered in Ingelheim, Germany. The company's research and development efforts focus on respiratory diseases, immunology, oncology, and diseases of the central nervous system. Boehringer Ingelheim Pharmaceuticals, Inc. was founded in 1885 and is based in Ridgefield, Connecticut.
Learn more about Boehringer Ingelheim Pharmaceuticals, Inc
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5,000 employees
Industry

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