Arrowhead Research

Director, IT Infrastructure

Arrowhead Research$190K — $210K *
Information Technology
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's degree in Computer Science, Information Systems, or related field.
  • 10+ years of IT infrastructure experience, including 4 years in a senior leadership role.
  • Expertise in virtualization (VMware, Nutanix, Hyper-V).
  • Experience managing Microsoft Active Directory in a multi-site environment.
  • Deep knowledge of AWS and Azure platforms with focus on architecture and security.
  • Proven ability to lead and develop high-performing infrastructure teams.
  • Understanding of pharmaceutical industry compliance frameworks.

Responsibilities

  • Define and implement a strategic IT infrastructure roadmap for growth.
  • Lead and mentor a geographically distributed infrastructure team.
  • Collaborate with IS leadership to align infrastructure investments with business needs.
  • Manage budgets and vendor contracts for infrastructure technology.
  • Establish and measure KPIs and operational metrics for infrastructure performance.
  • Drive and optimize hybrid cloud operations between Azure and AWS.
  • Oversee network infrastructure including LAN/WAN and SD-WAN connectivity.

Benefits

  • Comprehensive health insurance coverage.
  • 401(k) retirement plan with company matching.
  • Generous paid time off policy including holidays.
  • Continuous learning and development opportunities.
  • Employee assistance programs for mental health and wellbeing.
Full Job Description
The Position

The Director of IT Infrastructure is a leadership role responsible for the strategy, design, implementation, and ongoing operations of the company's enterprise IT infrastructure. This leader will oversee a geographically distributed environment spanning on-premises and public cloud platforms (Microsoft Azure and Amazon Web Services). The Director will lead a team of infrastructure staff to support business needs, drive modernization initiatives, and ensure the reliability and scalability of all infrastructure services in alignment with pharmaceutical industry standards.

This role is based onsite 5 days a week from one of Arrowhead's office locations.

Responsibilities
  • Define and execute a multi-year IT infrastructure roadmap aligned with corporate growth objectives and digital transformation priorities.
  • Lead, mentor, and develop a high-performing infrastructure team across multiple sites.
  • Partner with the IS leadership and business stakeholders to align infrastructure investments with organizational priorities and compliance requirements.
  • Establish and manage infrastructure budgets, vendor contracts, and technology refresh cycles.
  • Develop and communicate infrastructure KPIs, SLAs, and operational metrics to IS leadership.
  • Define and execute a multi-year IT infrastructure roadmap aligned with corporate growth objectives and digital transformation priorities.
  • Oversee the design, deployment, and lifecycle management of virtualization infrastructure across all company locations.
  • Manage a Microsoft Active Directory environment
  • Drive hybrid cloud strategy and operations across Azure and AWS, optimizing workload placement, cost, and performance.
  • Ensure high availability, disaster recovery, and business continuity capabilities for all critical infrastructure components.
  • Oversee network infrastructure including LAN/WAN and SD-WAN connectivity across all company sites and cloud tenants.
  • Oversee server patching and configuration management standards across the enterprise.
  • Lead capacity planning and performance monitoring to ensure infrastructure scalability in support of business growth.
  • Ensure all infrastructure platforms and processes comply with regulatory requirements as applicable.
  • Support internal and external audits by providing documentation, evidence, and technical guidance related to infrastructure controls.
  • Maintain and test disaster recovery and incident response plans in partnership with IS and business teams.
  • Lead infrastructure-related projects from inception through delivery, including consolidations, cloud migrations, and site expansions.
  • Manage relationships with key technology vendors and MSPs, negotiating contracts and ensuring service delivery accountability.
  • Evaluate and recommend emerging technologies that drive operational efficiency and cost reduction.

Requirements
  • Bachelor's degree in Computer Science, Information Systems, Information Technology, or a related field.
  • 10+ years of progressive IT infrastructure experience, with at least 4 years in a senior leadership or director-level role.
  • Deep hands-on expertise with virtualization platforms (VMware, Nutanix, Hyper-V).
  • Demonstrated experience managing Microsoft Active Directory.
  • Strong working knowledge of AWS and Azure - architecture, operations, cost management, and security.
  • Experience managing multi-site enterprise IT environments in a regulated industry.
  • Proven track record of building, leading, and developing high-performing infrastructure teams.
  • Strong understanding of network architecture, security principles, and ITIL-based service management frameworks.
  • Experience with infrastructure compliance frameworks relevant to pharma/biotech (GxP, SOX, HIPAA).

Preferred
  • Current or previous industry certifications such as VMware VCP/VCAP, Azure Administrator/Architect, AWS Solutions Architect, or ITIL v4.
  • Experience with infrastructure-as-code tools such as Terraform, Ansible, or Bicep.
  • Experience supporting laboratory and manufacturing IT environments (OT/IT convergence) within a pharmaceutical or life sciences setting.
  • Strategic thinking and the ability to translate business needs into scalable infrastructure solutions.
  • Strong communication skills - able to present complex technical topics clearly to non-technical audiences.
  • Exceptional organizational and prioritization skills in a fast-paced, regulated environment.
  • Collaborative leadership style with a strong emphasis on team development and cross-functional partnership.
  • Data-driven decision-making and a continuous improvement mindset.


Wisconsin pay range

$190,000-$210,000 USD

California pay range

$210,000-$230,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

About Arrowhead Research

Arrowhead Research is a biotechnology company that develops RNA interference (RNAi) therapeutics. The company was founded in 2007 and is headquartered in Pasadena, California. Arrowhead's RNAi technology targets specific genes to silence their expression, which can be used to treat a variety of diseases. The company's pipeline includes treatments for liver disease, cancer, and cardiovascular disease. Arrowhead has partnerships with pharmaceutical companies such as Amgen and Janssen Pharmaceuticals. The company has received FDA approval for some of its products and is conducting clinical trials for others.
Learn more about Arrowhead Research
Size
329 employees
Market Cap
$4 billion
Industry
Net Income
-$102.6 million
Founded
2004
5 Year Trend
+50.6%
Revenue
$79.8 million
NASDAQ

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