Flagship Pioneering

Director, Data Science and Machine Learning

Flagship Pioneering$232K — $319K *
Pharmaceuticals & Biotech
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • Masters or PhD in relevant field with 10+ years' experience in biotechnology
  • Experience in leadership roles driving results through interdisciplinary teams
  • Proficient in Python, ML frameworks, version control, and relevant informatics software
  • Proven success in managing complex programs with strategic resource allocation
  • Strong emotional intelligence to support team growth and navigate dynamics
  • Exceptional verbal and written communication skills to convey complex ideas to diverse audiences

Responsibilities

  • Pioneer and lead computational efforts for platform science
  • Develop a data framework for tracking DNA and chemistry relationships
  • Map out chemical representation options and build scalable chemistry frameworks
  • Lead predictive models and forecast data needs for strong predictions
  • Build computational capabilities for de-novo mass spec models
  • Integrate computational efforts across all platform workstreams
  • Serve as a cross-functional program lead guiding interdisciplinary teams

Benefits

  • Healthcare coverage
  • Annual incentive program
  • Retirement benefits
  • Broad range of other benefits
Full Job Description
Role

FL121 is seeking a talented and highly motivated Director (Data Science/ Machine Learning). We're looking for a resourceful computational problem solver and agile leader, someone who is not only scientifically rigorous and accountable for their and their team's work, but also has a high EQ and is a motivating force within cross-functional teams. The ideal candidate brings a track record of building computationally strong data environments, developing predictive models based upon internal and external databases, driving results in a fast paced and demanding environment, and enabling others to do their best work, all while communicating with clarity and empathy.

Key Responsibilities
  • Pioneer and lead computational efforts for FL121's platform science
  • Develop a data-framework and database for tracking DNA translation to chemistry, and chemistry to drug-characteristics in partnership with platform team
  • Strategically map out chemical representation optionality and develop framework for platform chemistry that can scale with data
  • Lead base-case chemical prediction models that can scale with data and forecast and scope data needs to enable models to have strong predictive power
  • Build and support computational capabilities to unlock de-novo mass spec deconvolution models
  • Integrate computational efforts across all platform workstreams to create a cohesive data-collection and integration workplace
  • Serve as a cross-functional program lead, guiding interdisciplinary teams of computational scientists, mass-spec scientists, medicinal chemists, and synthetic biologists toward shared goals.
  • Communicate computational goals, progress, and key decisions clearly across audiences, from scientists to executives, tailoring messaging with clarity and intention.
  • Build and manage budgets, thoughtfully allocating in-house and external resources to maximize impact while remaining cost-conscious and efficient.
  • Serve as a trusted, people-first leader fostering a collaborative, psychologically safe team environment that supports the scientific and personal development of team members.
  • Lead with authenticity and transparency, encouraging open dialogue, surfacing diverse perspectives, and engaging in courageous conversations when needed.

Professional Experience and Qualifications
  • Masters or PhD in a relevant field (e.g., computational chemistry, machine learning, data science, etc) with 10+ years' experience in scientific/engineering/computational settings in biotechnology settings; industry AI/ML experience preferred
  • Experience driving results directly or indirectly through teams of scientists and engineers in varied technical environments
  • Depth across multiple core tools and concepts, including, Python, modern ML frameworks (RDKit, scikit-learn, Chemprop, etc), version control, databases, deep learning architectures, and relevant informatics software (AWS, Seqera, Benchling, etc)
  • Demonstrated success as a team-oriented leader who motivates others and builds strong, trust-based relationships across functions
  • Proven ability to lead complex, cross-functional programs balancing scientific vision with disciplined execution and strategic resource management
  • Track record of intellectual agility and curiosity, with an ability to adapt quickly, think critically, and lead through ambiguity.
  • Strong emotional intelligence, with demonstrated maturity in navigating interpersonal dynamics, providing feedback, and supporting the growth of PhD and non-PhD scientists.
  • Exceptional communication skills, both written and verbal, with a consistent ability to convey complex ideas clearly and succinctly to diverse stakeholders.
  • A people-first, enterprise-minded approach that uplifts others, builds cohesion, and drives a culture of collaboration and accountability.


The salary range for this role is $232,000 - $319,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL121 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL121's good faith estimate as of the date of publication and may be modified in the future.

About Flagship Pioneering

Flagship Pioneering is a life sciences innovation enterprise that conceives, creates, resources, and develops first-in-category life sciences companies. The firm operates through its Flagship Labs unit, which is a dedicated innovation foundry that invents and launches transformative companies. Flagship Pioneering has created over 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. The firm's portfolio includes companies in the fields of therapeutics, health technologies, and sustainability. Flagship Pioneering was founded in 2000 and is headquartered in Cambridge, Massachusetts.
Learn more about Flagship Pioneering
Size
500 employees
Industry

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