AstraZeneca

Associate Principal Scientist, Biologics AI

AstraZeneca • $144K — $216K *
Cambridge, MA 02139In-Person
Pharmaceuticals & Biotech
8 - 10 years of experience
Today
Be an Early Applicant
Job Overview by Ladders

Qualifications

  • PhD in a quantitative field with 8+ years of relevant experience or Master's with 12+ years.
  • Proven application of AI/ML in biologics with measurable impact.
  • Hands-on leadership in advanced machine learning methodologies.
  • Experience with closed-loop experimental-computational integration.
  • Familiarity with full ML lifecycle and cloud-based environments.
  • Influential leadership in cross-disciplinary projects.
  • Excellent communication skills for diverse audiences.

Responsibilities

  • Define and execute the AI strategy for biologics innovation.
  • Lead cross-functional initiatives from inception to deployment.
  • Develop and apply advanced ML models for scientific problems.
  • Integrate computational and experimental workflows effectively.
  • Set standards for data generation and curation across teams.
  • Oversee the ML lifecycle from development to continuous improvement.
  • Mentor team members and contribute to recruitment efforts.

Benefits

  • Qualified retirement programs.
  • Paid time off (vacation, holiday, and leaves).
  • Health, dental, and vision coverage.
Full Job Description
About the Role
We are seeking an experienced and visionary Associate Principal Scientist to lead Biologics AI innovation at AstraZeneca's US R&D centers in Waltham, MA or Gaithersburg, MD. This is a high-impact scientific leadership role accountable for defining and executing the AI strategy that integrates state-of-the-art machine learning with wet-lab discovery to accelerate biologics engineering and enable next-generation biotherapeutics. You will set technical direction, own delivery across multiple programs, and shape data generation at scale-working across computational and experimental functions and with global partners to translate AI into robust, reproducible advances in discovery.

Key Responsibilities
  • Strategic leadership and vision: Define and drive the AI strategy for biologics discovery and engineering, setting priorities and roadmaps that integrate AI and wet-lab capabilities and deliver measurable impact on pipeline goals.
  • Program ownership: Lead multiple cross-functional discovery initiatives from problem framing through deployment, ensuring rapid translation of computational insights into experimental design and decision-making.
  • Advanced ML innovation: Architect, develop, and guide application of cutting-edge models-protein language models, structure-informed and geometric methods, de novo/protein design, and multi-modal learning that fuses sequence, structure, and biological activity data-to solve high-value scientific problems.
  • AI-wet-lab integration at scale: Establish closed-loop design-build-test-learn workflows with experimental teams, formalizing feedback cycles, uncertainty quantification, and active learning to improve model reliability and throughput.
  • Data strategy and governance: Set standards for high-quality data generation, curation, and metadata; partner with wet-lab leaders to design assays and campaigns that maximize ML utility and reproducibility; influence data platform evolution in collaboration with informatics and engineering.
  • End-to-end ML lifecycle leadership: Oversee and improve processes across data pipelines, model development, validation, deployment, monitoring, and continuous improvement, including best practices for reproducibility, documentation, and scientific rigor.
  • Technical mentorship and team development: Mentor and upskill scientists across AI/ML and experimental domains; provide day-to-day technical guidance and contribute to recruitment and development of a high-performing team.
  • Stakeholder influence and communication: Communicate strategy, progress, risk, and scientific insights to senior stakeholders; influence portfolio decisions and advocate for AI-enabled approaches internally and with external partners.
  • External scientific leadership: Drive publications, patents, and external visibility; represent AstraZeneca in collaborations and at scientific venues; evaluate and integrate emerging methods and tools.

Required Qualifications
  • Education and experience: PhD in computer science, machine learning, bioinformatics, computational biology, physics, chemistry, mathematics, engineering, or a related quantitative field, with typically 8+ years of relevant post-degree experience in academia and/or industry; or a Master's with 12+ years of relevant experience.
  • Domain impact in biologics AI: Demonstrated track record applying AI/ML to proteins, antibodies, or related biologics, with clear examples of methods translated into experimental outcomes, platform capabilities, or pipeline decisions.
  • Deep technical expertise: Hands-on leadership in developing and deploying advanced ML (deep learning, generative models, structure-aware and geometric methods, sequence/structure multi-modal models) for protein sequence modeling, structure-informed prediction, de novo design, or biologics optimization.
  • Closed-loop integration: Proven success establishing iterative computational-experimental cycles (e.g., active learning, design-build-test-learn), including designing experiments to interrogate model predictions and improve data/model quality.
  • Lifecycle and systems: Experience leading the full ML lifecycle at scale-data design and preprocessing, model architecture, training/evaluation, deployment, monitoring, and maintenance-using modern ML frameworks (e.g., PyTorch, TensorFlow) and software engineering best practices.
  • Data and platforms: Experience with cloud-based ML environments and scalable data workflows; ability to specify requirements and partner with data engineering/IT to evolve production ML systems that support discovery at scale.
  • Cross-functional leadership: Strong record of influencing and delivering in matrixed, multidisciplinary environments, bridging AI scientists, computational biologists, protein engineers, and wet-lab teams across sites.
  • Scientific communication: Excellent communication skills with the ability to synthesize complex technical concepts for diverse audiences and to shape scientific and portfolio decisions.
  • Innovation and delivery: Evidence of scientific innovation and impact through publications, patents, platform creation, or deployment of AI methods that materially improved experimental or business outcomes.

Preferred Qualifications
  • Protein and antibody engineering: Experience with antibody/nanobody/protein engineering, including de novo design and multi-objective optimization for developability, stability, and functional performance.
  • Advanced methodologies: Expertise with generative models (e.g., diffusion, autoregressive LMs), geometric deep learning/graph neural networks, Bayesian optimization, uncertainty quantification, and active learning for guided experimentation.
  • Multi-modal learning: Experience integrating heterogeneous data types (sequence, structure, biophysics/biochemistry assays, high-throughput binding/functional data, bioprocess/developability metrics) into unified models.
  • Productionization and MLOps: Experience leading deployment of scientific software/ML models into production discovery workflows, including model monitoring, versioning, and compliance with governance standards.
  • Data generation strategy: Demonstrated ability to design or refine assay strategies and experimental campaigns to maximize downstream ML performance and data reuse, including metadata standards and FAIR principles.
  • People and project leadership: Prior experience leading scientists and managing complex projects or collaborations; ability to set goals, delegate effectively, and deliver against timelines.
  • External profile: Strong external scientific presence (peer-reviewed publications, patents, invited talks, open-source contributions, or community standards).


The annual base pay for this position ranges from $144,648.80 - $216,973.20. Our positions offer eligibility for various incentives-an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted
07-Jul-2026

Closing Date
06-Jul-2026

About AstraZeneca

AstraZeneca is a British-Swedish multinational pharmaceutical company that specializes in the research, development, and manufacturing of prescription drugs. The company was formed in 1999 through the merger of Astra AB and Zeneca Group plc. AstraZeneca's products are used to treat a wide range of medical conditions, including cancer, cardiovascular disease, respiratory disease, and diabetes. The company has operations in over 100 countries and employs more than 76,000 people worldwide. AstraZeneca is committed to developing innovative medicines that improve the health and well-being of people around the world.
Learn more about AstraZeneca
Size
83,100 employees
Market Cap
$211.5 billion
Industry
Pharmaceuticals & Biotech
Net Income
$3.1 billion
Founded
1999
5 Year Trend
+10.2%
Revenue
$26.6 billion
NASDAQ
AZN
* Ladders Estimates

Similar Jobs

Ad banner background

Get Ready For Your
Next Interview

More Jobs at AstraZeneca

More Pharmaceuticals & Biotech Jobs

Find similar Associate Principal Scientist, Biologics AI jobs:

NationwideCambridge, MA