The Analytical Science team is looking for a talented scientist to collaboratively work with our R&D and Bioprocess teams to quantify and characterize broad classes of therapeutic proteins. A successful candidate will bring an outcome-oriented skillset to recombinant protein quantification and characterization. You will work collaboratively with our teams to produce and purify diverse proteins from cell culture processes and be comfortable conducting a wide range of protein quality assessments. This role will be based on-site in Emeryville, CA.
Key Responsibilities- Develop, optimize, and validate assays for protein quality and purity for broad classes of recombinant therapeutic proteins.
- Plan and execute experimentation to understand protein quality through cell line, upstream and downstream process development.
- Execute, summarize, and interpret routine and complex therapeutic protein characterizations.
- Qualify and validate assays upholding highly rigorous standards for execution and documentation.
- Routinely operate, maintain, and troubleshoot analytical instrumentation (HPLCs, FPLCs, mass spectrometers).
- Author, review, and implement methods, protocols, validations, and standard operating procedures.
- Ensure processes are followed in accordance with these standards.
Qualifications & Skills- Hold a PhD in Analytical Chemistry, Molecular Biology, Biochemistry, Pharmaceutical Sciences, with 1+ years of biologics industry experience. Candidates without a PhD but with similar industry experience are encouraged to apply.
- Have illustrated experience in therapeutic protein characterization approaches (eg. HPLC, SDS, CE, cIEF, LC-MS).
- Have illustrated the ability to develop, execute, and interpret intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping, peptide mapping) through mass spectrometry.
- Have illustrated the ability to develop, execute, and interpret aggregation and charge variant characterizations for biologics.
- Have experience in the development and execution of GLP-compliant methods characterizing protein quality attributes across a wide range of therapeutic classes.
- Have hands-on experience operating LC-MS. Experience with Agilent QTOF instrumentation applied to assay protein quality is a plus, including familiarity with proteomic software.
- Are highly motivated to deliver successful outcomes for internal and external clients.
- Are excited to work with internal and external clients to deliver project excellence.
- Have strong communication skills and are comfortable teaching and sharing knowledge at multiple levels of technical detail.
$120,000 - $140,000 a year
This role is salaried, exempt, and paid semi-monthly. Starting salary will be dependent upon specific experience, knowledge, and skillset. The range for the Scientist I level will typically fall between $120k-$140k.
Benefits: Generous equity package in an early stage company, retirement plan with company contribution, flexible PTO with healthy time off minimums, company-covered medical, dental, and vision insurance, life and disability insurance, career coaching, mental health support, free team lunches everyday, great snacks, and companywide social events!
