Gerontology and biogerontology subsume all research devoted to age-induced degeneration, preserving health for elderly populations, and prolonging human life in general.
The latest data seems to elect blood as an integral component of maintaining vigor into old age.
In a new study published in the journal Aging, researchers successfully rejuvenated three germ layer tissues in mouse models after exchanging old blood plasma with a mixture of saline and albumin (“neutral” age blood exchange, or NBE for short).
The team from UC Berkeley determined that replacing half of the blood plasma of old mice with NBE resulted in the albumin replacing the protein that was lost when the original blood plasma was removed.
The subsequent bio-reactions charted after analysis effectively reversed degenerative aging on the brain, liver, and muscle more significantly than outcomes that followed blood pairing with young mice or young blood exchanges.
Previously conducted research claimed that exchanging old blood plasma with blood plasma from young specimens offers the most robust anti-aging effects as far as degeneration is concerned. At present, simply diluting plasma factors appears to yield more priming results.
Although young mice did not seem to benefit from the same NBE procedure undertaken by their older counterparts, they showed no indications of enduring any adverse effects.
“Heterochronic blood sharing rejuvenates old tissues, and most of the studies on how this works focus on young plasma, its fractions, and a few youthful systemic candidates,” the authors write in the new paper. Our data demonstrate that a single NBE suffices to meet or exceed the rejuvenative effects of enhancing muscle repair, reducing liver adiposity and fibrosis, and increasing hippocampal neurogenesis in old mice, all the key outcomes seen after blood heterochronicity.”
The mechanisms behind this discovery can only be theorized at this early. However, The UC team put forth two strong potential explanations.
During the mouse joining experiments, rejuvenation might have occurred as a negation of young blood and young protein factors that become reduced as a result of aging.
The rejuvenation might have also occurred when harmful elevated protein in the blood of the old mice models was offset by the new NBE process.
From the report:
“This work improves our understanding of the systemic paradigms of multi-tissue rejuvenation and suggests a novel and immediate use of the FDA approved TPE for improving the health and resilience of older people.”
The wheels are already in motion for human applications. FDA approved plasma alterations can be achieved with a procedure called therapeutic plasma exchange(TPE), alternatively referred to as plasmapheresis.
As it stands, TPE is primarily used for the treatment of illness, not as a degenerative aging countermeasure.
“The research team is currently finalizing clinical trials to determine if a modified plasma exchange in humans could be used to improve the overall health of older people and to treat age-associated diseases that include muscle wasting, neuro-degeneration, Type 2 diabetes and immune deregulation,” the authors concluded.