Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Software Engineer II, Engineering
$125K - $145K *
Lead the charge in building impactful software features that enhance educators' management of English Learner programs, taking ownership from design to operation in a full-stack environment utilizing...
Reposted 2 weeks ago
Principal Engineer, Monetization Engineering
$223K - $317K *
Drive the evolution of a robust Fulfillment platform, shaping architecture and strategy while mentoring teams. Lead modernization efforts to enhance scalability, reliability, and performance, ensuring...
2 weeks ago
Staff Software Engineer, Frontend (Decisions Orechestration)
$230K - $290K *
Pioneer the future of checkout experiences by leading frontend engineering initiatives. Collaborate across teams to set technical strategies, enhance operational processes, and foster a culture of qua...
1 week ago
$135K - $160K *
Unlock your potential as a Lead Data Software Engineer, driving innovative data solutions and leading cross-functional teams to enhance our data infrastructure and ensure scalability and performance a...
3 weeks ago
$115K - $130K *
Join a team that's dedicated to developing innovative web and cloud applications. In this role, you'll lead projects, mentor junior engineers, and collaborate with cross-functional teams to deliver hi...
Reposted 1 week ago
Senior Technical Program Manager
$125K - $150K *
Transform complex customer implementations into seamless successes by owning the delivery lifecycle, driving technical discussions, and ensuring stakeholder satisfaction from kickoff to go-live. Your...
4 days ago
Senior Software Engineer, AI Automation
$130K - $195K *
Join a dynamic AI Automation team to design and deliver production-grade AI agents and workflows, enhancing operational efficiency across the organization while solving complex business challenges wit...
1 week ago
Senior Principal Software Engineer
$243K - $318K *
Elevate your career by providing technical leadership across Dev AI platforms. Shape architectural strategies, drive cross-organizational initiatives, and enhance engineering quality while collaborati...
2 weeks ago
Staff Software Developer [555]
$167K - $230K *
Develop high-performance software for quantum processors, driving architectural decisions, mentoring teams, and tackling complex challenges. Collaborate with interdisciplinary experts to enhance softw...
Reposted 4 days ago
Senior Machine learning Engineer
$162K - $258K *
Drive the design and implementation of cutting-edge GenAI solutions, leading the development of LLM capabilities and ML pipelines to enhance insurance workflows and deliver impactful outcomes for cust...
1 week ago
$124K - $170K *
Lead the charge in innovative software solutions for healthcare, collaborating with diverse teams to enhance patient care and meet customer needs through cutting-edge technology and creative problem-s...
2 weeks ago
Senior/Staff Software Engineer (Platform and Execution Model)
$180K - $240K *
Transform the future of distributed systems by designing and building robust platform components. Collaborate with teams to ensure reliability and scalability in mission-critical environments, driving...
3 weeks ago
Manager, Software Engineering - AI Tools
$120K - $150K *
Join a team that's shaping the future of AI engineering by leading a dynamic group of engineers and Technical Leads. Drive workforce strategy, enhance team capabilities, and ensure sustainable deliver...
2 weeks ago
Senior Engineering Manager, Clients Team
$242K - $275K *
Lead the charge in developing and deploying robust containerized software, manage CI/CD workflows, and grow a cohesive engineering team to enhance customer security operations and software delivery ac...
Reposted 4 weeks ago
Lead Software Engineer, AI Platform
$164K - $240K *
Collaborate with cross-functional teams to build AI infrastructure, ensure reliability and security, and guide technical direction while fostering engineer development. Lead innovative projects that e...
Reposted 2 weeks ago
Senior/Staff Full Stack Software Engineer
$180K - $240K *
Unlock innovative solutions as you build full-stack applications for federal partners, focusing on user experience, security, and seamless integrations. Collaborate with engineers and product teams to...
4 days ago
Software Engineer 5 - Training Platform, AI Platform
$466K - $500K+*
Join a team that's shaping the future of AI by designing and building scalable platforms for large-scale machine learning model training, enhancing performance, and creating user-friendly experiences...
5 days ago
Software Engineer, Design Systems
$130K - $170K *
Lead the evolution of our design system by building accessible, reusable components and collaborating with cross-functional teams to enhance user experiences and streamline adoption across products...
4 weeks ago
Principal Software Engineer, Core Engine
$179K - $341K *
Join a dynamic team to enhance C#/.NET integration for Unity Engine, driving performance and reliability. Collaborate with experts to deliver key technical solutions and advocate best practices for de...
Reposted 1 week ago
$105K - $147K *
Join us to accelerate progress at the forefront of software development for defense systems, engaging in the design, testing, and maintenance of robust solutions that support mission-critical operatio...
Reposted 1 week ago
Senior Software Engineer, AI Platform
$138K - $165K *
Transform AI capabilities by building robust SDKs and infrastructure. Collaborate with product teams to enhance agent workflows, ensuring reliability and performance while driving innovation in AI exp...
Today
$85K - $120K *
Elevate your career by joining our Innovation team as a Software Engineer. Collaborate on Proofs-of-Concept and drive features through the full software development lifecycle, from design to deploymen...
4 weeks ago
Senior Technical Product Manager
$153K - $213K *
Champion the development of a key platform, driving strategy, success metrics, and technical depth while collaborating across teams to deliver impactful solutions that meet customer needs and enhance...
3 weeks ago
Staff Software Engineer - Provider (Remote)
$125K - $150K *
Lead the development of innovative Provider Onboarding solutions, architecting robust systems and mentoring engineers to enhance mental healthcare access. Drive product implementations and build scala...
3 weeks ago
Senior Software Engineer - Growth
$120K - $145K *
Lead the charge in transforming patient engagement by integrating booking into our core product. Drive innovative experiments and optimize multi-channel outreach to ensure underserved communities rece...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.