Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$466K - $500K+*

Unlock potential by developing scalable AI/ML model serving infrastructure. Collaborate cross-functionally to enhance performance and availability of high-traffic systems, driving innovation in a dyna...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$160K - $200K *

Champion innovation as a Senior Software Engineer, driving full-stack solutions and leveraging AI tools to enhance IT lifecycle management. Collaborate with a dynamic team to deliver impactful softwar...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $130K *

Elevate your career by leading the design and development of embedded systems. Collaborate with cross-functional teams to enhance performance and security, ensuring robust solutions for vehicles and e...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $150K *

Empower our Digital team as a Senior Software Engineer, driving full stack development and modernization initiatives. Collaborate closely to enhance our Digital Banking platform, architecting new APIs...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$170K - $200K *

Advance backend solutions and frontend features, collaborating across teams to build scalable systems and AI integrations, driving product growth from conception to execution...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$115K - $194K *

Engage with the developer community as you advocate for our platform, creating compelling content, conducting demos, and gathering feedback to enhance product features, all while building relationship...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$200K - $250K *

Elevate the search experience by designing and evolving a robust backend system that powers millions of searches. Collaborate across teams to enhance scalability, reliability, and maintainability whil...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$218K - $256K *

Empower our engineering teams by owning core developer infrastructure tools and systems. Drive strategic initiatives, enhance CI/build processes, and ensure reliability while mentoring engineers and s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$135K - $160K *

Lead the charge in solving critical engineering challenges, driving technical direction, and fostering team growth. Collaborate across departments to enhance systems, ensuring reliability and innovati...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$157K - $184K *

Engineer and elevate our core product by developing innovative features, tools, and infrastructure while collaborating closely with a dedicated team to maintain high-quality standards and drive techni...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$122K - $168K *

Unlock your potential as a Senior Software Engineer, driving innovation in claims processing applications. Collaborate with cross-functional teams to design, develop, and modernize critical software s...

Today

  •   5 - 7 years exp.  •   Business Services

$165K - $225K *

Elevate infrastructure capabilities by designing and implementing a unified platform that integrates bare-metal servers, storage, and networking for large-scale computation and AI workloads, ensuring...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$199K - $274K *

Transform enterprise-scale engineering capabilities by leading the TORC function, fostering collaboration across security and operations, and delivering innovative solutions for risk and control manag...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$150K - $170K *

Transform the content platform by leading hands-on engineering initiatives. Design and implement shared services, ensuring security and stability while mentoring engineers and driving technical excell...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Champion the modernization of enterprise data tiers by automating database reliability engineering across hybrid cloud environments, enhancing performance, and ensuring high availability for mission-c...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Lead the development of critical firmware for safety-critical systems, collaborating across teams to optimize embedded platforms. Drive best practices and mentor engineers while ensuring reliability a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Transportation

$130K - $155K *

Join a dynamic team to architect and deliver a cloud-native maintenance planning tool, driving modernization efforts and collaborating with diverse stakeholders to ensure seamless project execution an...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$102K - $179K *

Unlock potential by designing and developing innovative software solutions that drive business objectives. Collaborate with cross-functional teams to tackle complex challenges and mentor engineers in...

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Unlock potential by leading frontend architecture for scalable, high-performance systems. Collaborate across teams to enhance user experiences and drive technical excellence in a dynamic, enterprise-l...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $160K *

Engage with engineers to enhance developer workflows and tools. Own the product lifecycle from discovery to adoption, ensuring high-quality internal software that meets user needs and drives efficienc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$94K - $157K *

Unlock your potential as a Senior Software Developer, designing and integrating critical applications for national security. Collaborate cross-functionally while leveraging your expertise in software...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Champion customer success by leading enterprise deployments and integrations. Drive technical direction and enhance automation for cloud services, ensuring seamless operations and improved customer ex...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$388K - $500K+*

Lead the charge in enhancing mobile architecture and quality for Android, driving multi-quarter initiatives that empower engineering teams to innovate and deliver exceptional user experiences at scale...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Hospitality & Recreation

$95K - $115K *

Unlock your potential by developing innovative software solutions using C#, .NET, and Azure. Collaborate with cross-functional teams to enhance business operations and drive technology initiatives tha...

5 days ago

  •   5 - 7 years exp.  •   Transportation

$170K - $200K *

Lead technical direction for a healthcare data team, driving architectural decisions and cross-team initiatives to enhance compliance and operational efficiency. Elevate team performance while solving...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.