Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Explore the dynamic role of a Program Manager, overseeing end-to-end data collection programs. Drive operational excellence, client satisfaction, and strategic execution in a fast-paced environment, e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Join a dynamic team to define and design life sciences manufacturing processes, ensuring compliance and efficiency in facility layouts. Collaborate with multidisciplinary teams to translate complex re...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $180K *

Shape the future of product management by leading complex engagements, defining vision, and ensuring seamless collaboration across teams to deliver exceptional results and drive product success...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$104K - $155K *

Lead the charge in customer-focused project management, ensuring effective delivery of technical solutions while coordinating with diverse stakeholders and fostering strong relationships for successfu...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$118K - $196K *

Elevate your career as a key member of an agile software engineering team, driving the design and development of scalable applications. Collaborate across all stages of the software lifecycle to deliv...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Engage with cross-functional teams to drive AI security product marketing initiatives, focusing on buyer insights, competitive analysis, and effective sales enablement. Collaborate on launches and con...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$96K - $181K *

Lead the transformation of enterprise technology by architecting scalable GCP solutions and guiding cross-functional teams in developing robust AI-driven applications. Drive innovation through hands-o...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$123K - $185K *

Lead the charge in optimizing process control and equipment projects across multiple manufacturing plants, driving improvements and ensuring effective implementation in the Feed Manufacturing Operatio...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$107K - $145K *

Drive success by managing complex technology construction projects, optimize resources, ensure client satisfaction, and lead teams to achieve high quality and productivity in project completion. Trave...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $155K *

Lead the charge in developing Fleetio's connected-vehicle data strategy and product line from the ground up. Drive innovative data solutions, partnerships, and user experiences that enhance fleet oper...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$193K - $228K *

Join a dynamic team to lead complex, cross-functional programs, ensuring timely delivery of high-quality features while driving alignment across Product, Engineering, and Design teams in a fast-paced...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$111K - $167K *

Engage with clients to identify needs and drive successful adoption of quantum solutions. Collaborate with internal teams to deliver value, provide expert technical support, and foster long-term relat...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Analyze technical sales opportunities from discovery to close, leveraging AI tools and client data to drive business cases. Collaborate with cross-functional teams to ensure seamless implementation an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$119K - $179K *

Support the integration and harmonization of clinical data by designing FHIR-compliant models and pipelines, ensuring data accuracy and usability for patient care and research initiatives across the o...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$330K - $500K *

Shape the future of content discovery by leading product operations and program management. Drive efficiency and innovation across teams, ensuring seamless collaboration and execution of high-impact i...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$130K - $140K *

Elevate your career by joining a dynamic team to design and implement innovative cloud solutions in a multi-cloud environment, ensuring scalability, security, and alignment with business objectives wh...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Transform your career by leading Microsoft Cloud security projects, deploying SIEM and XDR solutions, and enhancing customer environments. Collaborate with a dynamic team to drive innovation in Manage...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Engage with our Technical Support team to tackle complex issues for enterprise health systems. Drive incident resolution, enhance support processes, and mentor junior engineers while shaping the futur...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$179K - $248K *

Lead the charge in operationalizing strategy and driving cross-division initiatives. Collaborate with senior stakeholders to enhance efficiency and client satisfaction in a fast-paced corporate travel...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$170K - $220K *

Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Elevate your mechanical design career by collaborating with project teams to produce accurate and detailed mechanical plans, ensuring compliance with design standards, and delivering innovative soluti...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $145K *

Lead quantitative user research across product lines, shaping strategy and answering critical questions with data-driven insights. Collaborate with teams to prioritize research that mitigates risk and...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Unlock the potential of aseptic manufacturing processes as a Senior Engineer. Drive innovations in equipment design and optimization, ensuring compliance with regulatory standards while enhancing oper...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Drive the evolution of our enterprise-scale PaaS by ensuring reliable operations, enhancing platform components, and supporting customer needs while meeting stringent security requirements in a dynami...

3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$110K - $130K *

Transform clinical data programming by developing scalable Python solutions, modernizing SAS workflows, and building reusable frameworks to enhance clinical trial data delivery and influence technolog...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.